A5034261410- Genetics, Aging, and Longevity in Model Organisms
- Frailty in Older Adults
- Nutrition and Health in Aging
- Animal Behavior and Reproduction
- Health Systems, Economic Evaluations, Quality of Life
- Physiological and biochemical adaptations
- Health disparities and outcomes
- Health, Environment, Cognitive Aging
- Aging and Gerontology Research
- Nutritional Studies and Diet
- Mental Health Research Topics
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Immune responses and vaccinations
- Climate Change and Health Impacts
- Gene Regulatory Network Analysis
- Bioinformatics and Genomic Networks
- Immune Cell Function and Interaction
- Ecosystem dynamics and resilience
- Machine Learning in Bioinformatics
- Circadian rhythm and melatonin
- Metabolomics and Mass Spectrometry Studies
- Birth, Development, and Health
- Atherosclerosis and Cardiovascular Diseases
- Antioxidant Activity and Oxidative Stress
Columbia University
2023-2025
Université de Sherbrooke
2015-2024
Centre Hospitalier Universitaire de Sherbrooke
2010-2024
Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal
2020-2023
Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean
2020-2023
Creative Commons
2023
DePaul University
2023
Institute on Aging
2014-2021
Eidos Education
2020
McGill University Health Centre
2020
The geroscience hypothesis posits that therapies to slow biological processes of aging can prevent disease and extend healthy years life. To test such "geroprotective" in humans, outcome measures are needed assess extension disease-free life span. This need has spurred development different methods quantify aging. But have not been systematically compared the same humans. We implemented 7 using repeated-measures physiological genomic data 964 middle-aged humans Dunedin Study (New Zealand;...
Randomized controlled trials (RCTs) have traditionally been considered the gold standard for medical evidence. However, in light of emerging methodologies data science, many experts question role RCTs. Within this context, USA and Canada came together to debate whether primacy RCTs as evidence, still holds recent methodological advances science era big data. The purpose manuscript, aims raise awareness pros cons observational studies order help guide clinicians, researchers, students,...
Understanding immune function in the context of other life-history traits is crucial to understand evolution life histories, at both individual and species levels. As interest assessing for these comparative purposes grows, an important question remains unanswered: can be broadly characterized using one or two simple measures? Often, interpretation assays ambiguous relationships among different measures remain poorly understood. Thus, we employed five protocols measure 13 variables ten...
Summary An increasing number of aging researchers believes that multi‐system physiological dysregulation may be a key biological mechanism aging, but evidence this has been sparse. Here, we used biomarker data on nearly 33 000 individuals from four large datasets to test for the presence dysregulation. We grouped 37 biomarkers into six priori groupings representing systems (lipids, immune, oxygen transport, liver function, vitamins, and electrolytes), then calculated scores each system in...
Recent functional, proteomic and ribosome profiling studies in eukaryotes have concurrently demonstrated the translation of alternative open-reading frames (altORFs) addition to annotated protein coding sequences (CDSs). We show that a large number small proteins could fact be coded by these altORFs. The putative translated from altORFs orthologs many species contain functional domains. Evolutionary analyses indicate often more extreme conservation patterns than their CDSs. Thousands are...
Objectives. We compared the social participation of older adults living in metropolitan, urban, and rural areas, identified associated environmental factors. Methods. From 2004 to 2006, we conducted a cross-sectional study using an age-, gender-, area-stratified random sample 1198 (aged 67–82 years). collected data via interviewer-administered questionnaires derived from Canadian censuses. Results. Social did not differ across areas (P = .09), but after controlling for potential confounding...