A5044308432- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Testicular diseases and treatments
- Chromosomal and Genetic Variations
- Cancer-related molecular mechanisms research
- Chronic Myeloid Leukemia Treatments
- RNA modifications and cancer
- Neurological disorders and treatments
- Ovarian cancer diagnosis and treatment
- Microtubule and mitosis dynamics
- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Developmental Biology and Gene Regulation
- Peroxisome Proliferator-Activated Receptors
- Lymphoma Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Genomic variations and chromosomal abnormalities
- Cancer therapeutics and mechanisms
- Renal Diseases and Glomerulopathies
- Parkinson's Disease Mechanisms and Treatments
- Cancer-related gene regulation
- Chronic Lymphocytic Leukemia Research
- Adipokines, Inflammation, and Metabolic Diseases
Instituto Nacional de Cancerología
2013-2024
Universidad Nacional Autónoma de México
2011-2024
Instituto Nacional de Cancerología
2021
Sergio Arboleda University
2017
Simón Bolívar University
2015
Centro de Investigación Biomédica en Red de Cáncer
2012
University of Chile
1991-2009
The aim of this study was to investigate the feasibility saliva sampling as a non-invasive and safer tool detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compare its reproducibility sensitivity with nasopharyngeal swab samples (NPS). use sample pools also investigated.A total 2107 paired were collected from asymptomatic healthcare office workers in Mexico City. Sixty these analyzed two other independent laboratories for concordance analysis. Sample processing analysis...
COVID-19 is an infection caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2), which has a global outbreak. Current research efforts are focused on the understanding of molecular mechanisms involved in order to propose drug-based therapeutic options. Transcriptional changes due epigenetic regulation key host cell responses viral and have been studied SARS-CoV MERS-CoV; however, such not fully described for SARS-CoV-2. In this study, we analyzed multiple transcriptomes...
Cisplatin cures over 80% of testicular germ cell tumours (TGCTs), and nucleotide-excision repair (NER) modifies the sensitivity to cisplatin. We explored association between NER proteins their polymorphisms with cisplatin (CPS) overall survival (OS) patients non-seminomatous (ns)-TGCTs. The expression ERCC1 XPA presence γH2AX were evaluated in cancer lines fresh ns-TGCTs. protein was also determined differences CPS non-CPS analysed by Student's t- or χ2-tests. OS using log-rank test, hazard...
Extrasynaptic α5 -subunit containing GABAA (α5 -GABAA ) receptors participate in chronic pain. Previously, we reported a sex difference the action of dysfunctional However, underlying mechanisms remain unknown. The aim this study was to examine sexual dimorphism neuropathic rodents and involved. Female male Wistar rats or ICR mice were subjected nerve injury followed by receptor inverse agonist intrathecal administration, L-655,708. drug produced an antiallodynic effect nerve-injured female...
Abstract Background In cancer cells, transcriptional gene silencing has been associated with genetic and epigenetic defects. The disruption of DNA methylation patterns covalent histone marks development. Until recently, microRNA (miRNA) was not well understood. particular, miR-125b1 suggested to be an miRNA tumor suppressor activity, it shown deregulated in various human cancers. the present study, we evaluated at CpG island proximal transcription start site cell lines as normal tissues...
Satellite sequences are an important part of the pericentromeric regions in mammalian genomes; they play a relevant role chromosome stability and DNA hypomethylation these has been reported ICF syndrome some cancers that closely associated with chromosomal abnormalities. Epigenetic modifications satellite their consequences have not extensively studied human cells. In present work, we evaluated 2 methylation patterns lymphocytes exposed to 5-azacytidine (5-azaC) assessed relationship between...
Abstract The identification of prognostic biomarkers is a priority for patients suffering from high-grade serous ovarian cancer (SOC), which accounts >70% (OC) deaths. Meanwhile, borderline (BOC) low malignancy tumor and usually undergo surgery with probabilities recurrence. However, SOC remains the most lethal neoplasm due to lack early diagnosis prognosis. In this regard, BORIS ( CTCFL ), CTCF paralog, promising biomarker that overexpressed controls transcription in several types,...
Breast cancer is one of the leading causes mortality in women worldwide, and neoadjuvant chemotherapy has emerged as an option for management locally advanced breast cancer. Extensive efforts have been made to identify new molecular markers predict response chemotherapy. Transcripts that do not encode proteins, termed long noncoding RNAs (lncRNAs), shown display abnormal expression profiles different types cancer, but their role biomarkers extensively studied. Herein, lncRNA was profiled...
The axolotl, known for its remarkable regenerative abilities, is an excellent model studying therapies. Nevertheless, the precise molecular mechanisms governing potential remain uncertain. In this study, we collected samples from axolotls of different ages, including 8‐year‐old individuals and 8‐month‐old juveniles, obtaining their blastemas 10 days after amputation. Subsequently, conducted a transcriptomic analysis comparing our to set previously published experiments. Our unveiled...
Abstract High-grade serous ovarian carcinoma (HGSC) is the most lethal gynecologic malignancy due to lack of reliable biomarkers, effective treatment, and chemoresistance. Improving diagnosis development targeted therapies still needed. The molecular pathomechanisms driving HGSC progression are not fully understood though crucial for identification novel therapy options. oncogene CTCFL (BORIS), paralog CTCF, a transcriptional factor highly expressed in cancer (but rarely any other tissue...
Despite having a favorable response to platinum-based chemotherapies, ~15% of Testicular Germ-Cell Tumor (TGCT) patients are platinum-resistant. Mortality rates among Latin American countries have remained constant over time, which makes the study this population particular interest. To gain insight into phenomenon, we conducted whole-exome sequencing, microarray-based comparative genomic hybridization, and copy number analysis 32 tumors from Mexican cohort, 18 were platinum-sensitive 14 We...
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm defined by the presence of t(9;22) translocation whose origin has been associated with tridimensional genome organization. This rearrangement leads to fusion BCR and ABL1 genes giving rise chimeric protein constitutive kinase activity. Imatinib, tyrosine inhibitor (TKI), used as first-line treatment for CML, though ~40% CML patients do not respond. Here, using structured illumination microscopy (SIM) 3D reconstruction, we...