A5008151485- Folate and B Vitamins Research
- Multiple Myeloma Research and Treatments
- Esophageal and GI Pathology
- Neuroendocrine Tumor Research Advances
- Amoebic Infections and Treatments
- Heavy Metal Exposure and Toxicity
- Parasitic Infections and Diagnostics
- Iron Metabolism and Disorders
- Takotsubo Cardiomyopathy and Associated Phenomena
- Neuroendocrine regulation and behavior
- Fungal and yeast genetics research
- Mercury impact and mitigation studies
- Signaling Pathways in Disease
- Uterine Myomas and Treatments
- Electroconvulsive Therapy Studies
- Nuclear Receptors and Signaling
- Urinary and Genital Oncology Studies
- GDF15 and Related Biomarkers
- Genetic and Environmental Crop Studies
- Prostate Cancer Treatment and Research
- Diabetes and associated disorders
- Occupational and environmental lung diseases
- Immune Cell Function and Interaction
- HIV-related health complications and treatments
- Mycotoxins in Agriculture and Food
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2015-2024
University Hospitals of Cleveland
2021
Case Western Reserve University
2021
Hospital of the University of Pennsylvania
2021
Universidad Nacional Autónoma de México
2010
Universidad de Extremadura
2008-2010
Inserm
2006
University of Lomé
2006
Università Cattolica del Sacro Cuore
2006
Université de Bourgogne
2006
Journal Article Corrected proof Challenging the paradigm: a case of early-onset VEXAS syndrome Get access Beatriz E Sánchez-Hernández, Sánchez-Hernández Department Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Search for other works by this author on: Oxford Academic PubMed Google Scholar Ivette Calderón-Espinoza, Calderón-Espinoza Colegio Jalisciense Reumatología, Guadalajara, Eduardo Martín-Nares Immunology and Rheumatology, Correspondence to:...
Extrasynaptic α5 -subunit containing GABAA (α5 -GABAA ) receptors participate in chronic pain. Previously, we reported a sex difference the action of dysfunctional However, underlying mechanisms remain unknown. The aim this study was to examine sexual dimorphism neuropathic rodents and involved. Female male Wistar rats or ICR mice were subjected nerve injury followed by receptor inverse agonist intrathecal administration, L-655,708. drug produced an antiallodynic effect nerve-injured female...
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Folate deficiency has been related to several conditions, including neural tube defects (NTDs) and cardiovascular diseases. Hence, MTHFR genetic variants have studied worldwide, particularly the C677T A1298C. We genotyped A1298C polymorphisms Mexican Amerindians (MAs), from largest sample included study (n = 2026, 62 ethnic groups), geographically-matched Mestizo population (MEZ, n 638). The 677T allele was...
Chronic inflammation causes target organ damage in patients with systemic autoimmune diseases. The factors that allow this protracted response are poorly understood. We analyzed the transcriptional regulation of PPP2R2B (B55β), a molecule necessary for termination immune response, Altered expression B55β conditioned resistance to cytokine withdrawal–induced death (CWID) impaired upregulation was caused by inflammation-driven hypermethylation specific cytosines located within regulatory...
<b>Background:</b> A 776C→G variant (dbSNP ID: rs1801198) in the transcobalamin gene (<i>TCN2</i>; MIM# 275350) decreases cellular and plasma concentration of thereby influences availability vitamin B<sub>12</sub>. <b>Objective:</b> To evaluate worldwide prevalence this its association with homocysteine level. <b>Methods:</b> The study was performed 1433 apparently healthy subjects, including Afro-Americans Afro-Africans 251 participants severe malaria. <b>Results:</b> frequencies 776G...
Entamoeba histolytica is a protozoan parasite that causes amoebiasis, an illness affects many people around the world. We have previously reported lactoferrin able to kill E. in vitro cultures. The aim of present study was evaluate therapeutic effect orally administered bovine control intestinal amoebiasis susceptible C3H/HeJ mice. results showed 20 mg lactoferrin/kg each day for 1 week eliminate infection 63% mice, since neither trophozoites nor evidence epithelial damage and (or) swelling...
Tumor suppressor gene promoter CpG island methylation is a well-recognized mechanism in cancer pathogenesis, but its role multiple myeloma (MM) controversial. The present study investigated the status and expression of P16, cytokine signaling 1 (SOCS-1), P73, E-cadherin Src homology region 2 domain-containing phosphatase (SHP-1), as well global patients with MM during active disease remission. Bone marrow samples were obtained from 43 at Multiple Myeloma Clinic, Instituto Nacional de...
Tobacco smoking is a leading cause of mortality in developed and developing countries. Despite antitobacco smoke-free policies, the prevalence active smokers Mexican urban populations has remained stable. differ from Caucasian other ethnic groups, probably due to sociocultural genetic background characteristics. This study explored effect known variants on behavior Mexico City residents. Three hundred sixty-four Mestizo residents 87 families with at least one smoker were assessed for...
Tuberculosis is still a global public health problem, with an estimated 10 million new cases and 1.6 deaths in 2017. Of all humans infected M. tuberculosis , only 10-15% will develop active disease during their lifetime, data suggest that along environmental factors, genetic factors influence susceptibility to disease. Toll-like receptors (TLRs) are pattern recognition play central role the initiation shaping of adaptive immune responses, several TLRs have been shown recognize mycobacterial...
Abstract Background Indigenous populations globally face significant health disparities compared to non-Indigenous groups, primarily due marginalization and limited access healthcare. In Mexico, which is home the largest population in Americas, these were further exacerbated by COVID-19 pandemic, with impacts intensified factors such as marginalization, discrimination, inadequate essential services. Methods This study aimed investigate pandemic's impact on mortality, vaccination uptake,...
Abstract Background Therapy-related acute monocytic leukemias in patients with plasma cell dyscrasias are infrequent. Case presentation We here present a case of 60 year old female who developed an leukemia two years after the diagnosis multiple myeloma. She was treated alkylating agent and bortezomib before undergoing hematopoietic stem transplantation. suffered severe infections until her immune system adequately reconstituted. A afterwards, she presented signs deterioration unrelated to...
Abstract Background Adenomatoid tumor (AT) is an ambiguous term used to describe benign mesothelial neoplasms, most often reported in organs of the reproductive system. Their neoplastic nature has been proven through confirmation pathogenic mutations TRAF7. Several studies have association between AToU and immunosuppression. groups hypothesized immunosuppression causes abnormal inflammatory state within cells, increasing likelihood a selective activating Case presentation A 34 year old...