A5075162828- Folate and B Vitamins Research
- Metabolism and Genetic Disorders
- Drug-Induced Adverse Reactions
- Birth, Development, and Health
- Asthma and respiratory diseases
- Porphyrin Metabolism and Disorders
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Esophageal and GI Pathology
- Long-Term Effects of COVID-19
- Contact Dermatitis and Allergies
- COVID-19 Clinical Research Studies
- Allergic Rhinitis and Sensitization
- Diet and metabolism studies
- Pregnancy and preeclampsia studies
- Nutrition, Genetics, and Disease
- Mitochondrial Function and Pathology
- Monoclonal and Polyclonal Antibodies Research
- Urticaria and Related Conditions
- Neonatal Health and Biochemistry
- Mast cells and histamine
- Diet, Metabolism, and Disease
- Cardiovascular Function and Risk Factors
- Ferroptosis and cancer prognosis
- Gestational Diabetes Research and Management
Université de Lorraine
2016-2025
Inserm
2014-2024
Ingénierie Moléculaire et Physiopathologie Articulaire
2016-2024
Centre de Recherche en Automatique de Nancy
2023-2024
Centre Hospitalier Régional et Universitaire de Nancy
2004-2023
Nutrition-Génétique et Exposition aux Risques Environnementaux
2005-2019
Délégation Centre-Est
2013
Laboratoire de Chimie Physique et Microbiologie pour l'Environnement
2013
Stress Environnementaux et Biosurveillance des Milieux Aquatiques
2005-2013
GTx (United States)
2011
In patients with documented IgE-mediated hypersensitivity to penicillins, data on sensitization cephalosporins vary. Administering such is often deferred because of the risk for cross-reactivity.To assess cross-reactivity and its potential determinants in penicillin allergy.Prospective study without clinical indications cephalosporin treatment.Italy.128 consecutive who sustained anaphylactic shock (n = 81) or urticaria 47) had positive results skin tests at least 1 reagents tested.All were...
Highlights•Patients with cirrhosis are at high risk of hepatocellular carcinoma (HCC).•Accurate tumor biomarkers for the diagnosis and early detection HCC need to be developed.•The circulating, cell-free, epigenetic biomarker mSEPT9 is a promising diagnosing in patients cirrhosis.Patients (HCC). Several circulating markers under evaluation HCC, notably those identified through "omics" approaches. However, date, no has been shown useful individual patient level. Through initial replication...
Background/Objectives: Vitamin B12 deficiency can cause variable symptoms, which may be irreversible if not diagnosed and treated in a timely manner. We aimed to develop widely accepted expert consensus guide the practice of diagnosing treating deficiency. Methods: conducted scoping review literature published PubMed since January 2003. Data were used design two-round Delphi survey study level among 42 experts. Results: The panelists agreed on need for educational organizational changes...
Abstract Contradictory findings have been recently published on the evaluation of genetic polymorphisms methylenetetrahydrofolate reductase (MTHFR 677 C→T) and methionine synthase (MTRR 66 A→G) as risk factors for having a child with Down syndrome (DS); however, influence (MTR 2756 MTHFR 1298 A→C has never evaluated. In this study, being DS case or (case mother) was studied by multiple logistic regression analysis independent combined genotypes plasma homocysteine, folates, vitamin B12 in 92...
Summary Background After penicillins, cephalosporins are the betalactams that most often induce IgE‐mediated reactions. The development of diagnostic tests has been delayed, however, because cephalosporin allergenic determinants have not properly identified. Objective To evaluate usefulness skin tests, serum specific IgE assays, and challenges in diagnosing immediate reactions to clarify pathogenic mechanism such Methods We studied 76 adults with cephalosporins, mainly ceftriaxone,...
Cardiomyopathies occur by mechanisms that involve inherited and acquired metabolic disorders. Both folate vitamin B12 deficiencies are associated with left ventricular dysfunction, but underlie these associations not known. However, methyl donors needed for the synthesis of S-adenosylmethionine, substrate required activation methylation regulators energy metabolism. We investigated consequences a diet lacking in myocardium weaning rats from dams subjected to deficiency during gestation...
Abstract Neural tube defects (NTDs) are severe congenital malformations due to failure of neural formation in early pregnancy. The proof that folic acid prevents NTDs raises the question whether other parts homocysteine (Hcy) metabolism may affect rates NTDs. This French case‐control study covered: 77 women aged 17–42 years sampled prior elective abortion for a (cases) and 61 20–43 with normal Plasma erythrocyte folate, plasma B6, B12 Hcy were tested as five polymorphisms MTHFR 677 C → T ,...
Abstract The pathomechanisms that associate a deficit in folate and/or vitamin B12 and the subsequent hyperhomocysteinemia with pathological brain ageing are unclear. We investigated homocysteinylation of microtubule‐associated proteins (MAPs) brains patients Alzheimer's disease or vascular dementia, rats depleted B12, Cd320 KO mice selective deficiency H19‐7 neuroprogenitors lacking folate. Compared controls, N‐homocysteinylated tau MAP1 were increased accumulated protein aggregates tangles...
Background/Objectives: Vitamin B12 deficiency can cause variable symptoms, which may be irreversible if not diagnosed and treated in a timely manner. We aimed to develop widely accepted expert consensus guide the practice of diagnosing treating deficiency. Methods: conducted scoping review literature published PubMed since January 2003. Data were used design two-round Delphi survey study level among 42 experts. Results: The panelists agreed on need for educational organizational changes...
ABSTRACT Background Beta‐lactams (BLs) are the predominant cause of immediate allergic reactions to drugs. Immediate hypersensitivity (IHR) with positive provocation tests and negative skin in vitro have undetermined mechanisms. We evaluated whether biomarkers IgG‐dependent neutrophil activation could help assess this subgroup BL IHRs. Methods extracellular traps (NETs) serum 26 IHR patients presenting a test, specific IgE, sIgG, 8 perioperative cases sIgE compared 19 non‐allergic matched...
Haptoglobin is an acute phase inflammatory marker. Its main function to bind hemoglobin released from erythrocytes aid its elimination, and thereby haptoglobin prevents the generation of reactive oxygen species in blood. levels have been repeatedly associated with a variety inflammation-linked infectious non-infectious diseases, including malaria, tuberculosis, human immunodeficiency virus, hepatitis C, diabetes, carotid atherosclerosis, myocardial infarction. However, comprehensive genetic...
Abstract Background Betalactam ( BL ) immediate‐type allergy is influenced by environmental and genetic determinants, as illustrated differences in worldwide prevalence ethnicity from a same area associations with genes related to atopy. Aims To evaluate the association of atopy allergy. Materials methods We measured specific I mmunoglobulin E g against prevalent allergens predictors atopy, IL 13 , 4 RA TNFA 340 patients controls S outh pain. Results Total mites were at higher concentration...