Federico Centeno-Cruz
A5014231493- Genetic Associations and Epidemiology
- Pancreatic function and diabetes
- Epigenetics and DNA Methylation
- Metabolism, Diabetes, and Cancer
- Genomics, phytochemicals, and oxidative stress
- Adipose Tissue and Metabolism
- RNA Research and Splicing
- Genomics and Rare Diseases
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Diabetes Treatment and Management
- Cancer-related gene regulation
- Helicobacter pylori-related gastroenterology studies
- Dietary Effects on Health
- Cystic Fibrosis Research Advances
- Diet, Metabolism, and Disease
- Acute Lymphoblastic Leukemia research
- Forensic and Genetic Research
- Genetics and Neurodevelopmental Disorders
- T-cell and Retrovirus Studies
- Peroxisome Proliferator-Activated Receptors
- Bioinformatics and Genomic Networks
- Cancer-related molecular mechanisms research
- Nutrition, Genetics, and Disease
National Institute of Genomic Medicine
2015-2024
Secretaria de Salud
2016-2024
Instituto de Medicina Genómica
2010-2016
Center for Research and Advanced Studies of the National Polytechnic Institute
2005-2011
Instituto Politécnico Nacional
2005-2008
Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals with type 2 diabetes (T2D) and 24,440 non-diabetic control participants from 5 ancestries. We identify gene-level associations rare (with minor allele frequencies less than 0.5%) in 4 genes at exome-wide significance, including a series more 30 SLC30A8 alleles conveys protection against T2D, 12 gene sets, those...
<h3>Importance</h3> Latino populations have one of the highest prevalences type 2 diabetes worldwide. <h3>Objectives</h3> To investigate association between rare protein-coding genetic variants and prevalence in a large population to explore potential molecular physiological mechanisms for observed relationships. <h3>Design, Setting, Participants</h3> Whole-exome sequencing was performed on DNA samples from 3756 Mexican US individuals (1794 with 1962 without diabetes) recruited 1993 2013....
Abstract Hundreds of thousands genetic variants have been reported to cause severe monogenic diseases, but the probability that a variant carrier develops disease (termed penetrance) is unknown for virtually all them. Additionally, clinical utility common polygenetic variation remains uncertain. Using exome sequencing from 77,184 adult individuals (38,618 multi-ancestral type 2 diabetes case-control study and 38,566 participants UK Biobank, whom genotype array data were also available), we...
Systemic lupus erythematosus (SLE) is an autoimmune disease associated with oxidative stress and characterized by chronic inflammation. Kidney malfunction, aggressive characteristic of this disease, not present in all affected individuals. The Nrf2-Keap1 pathway important protecting against Mouse models genome-wide scans have suggested NRF2 (Nuclear factor (erythroid-derived 2)-like 2) as a candidate gene for susceptibility to SLE. We therefore investigated whether polymorphisms are...
Type 2 diabetes (T2D) affects more than 415 million people worldwide, and its costs to the health care system continue rise. To identify common or rare genetic variation with potential therapeutic implications for T2D, we analyzed replicated genome-wide protein coding in a total of 8,227 individuals T2D 12,966 without Latino descent. We identified novel variant IGF2 gene associated ∼20% reduced risk T2D. This variant, which has an allele frequency 17% Mexican population but is Europe,...
An Amerindian genetic background could play an important role in susceptibility to metabolic diseases, which have alarmingly increased recent decades. Mexico has one of the highest prevalences disease worldwide. The purpose this study was determine prevalence syndrome and its components a population with high ancestry.We performed descriptive, quantitative, analytical cross-sectional 2596 adult indigenous volunteers from 60 different ethnic groups. Metabolic were evaluated using American...
Abstract The genetic makeup of Indigenous populations inhabiting Mexico has been strongly influenced by geography and demographic history. Here, we perform a genome-wide analysis 716 newly genotyped individuals from 60 the 68 recognized ethnic groups in Mexico. We show that structure these is geography, our reconstructions suggest decline population size all tested last 15–30 generations. find evidence Aridoamerican Mesoamerican diverged roughly 4–9.9 ka, around time when sedentary farming...
Obesity is a well-recognized risk factor for insulin resistance and type 2 diabetes (T2D), although the precise mechanisms underlying relationship remain unknown. In this study we identified alterations of DNA methylation influencing T2D pathogenesis, in subcutaneous visceral adipose tissues, liver, blood from individuals with obesity. The included obesity, without T2D. From these patients, obtained samples liver tissue (n = 16), tissues 30), peripheral 38). We analyzed using Illumina...
Abstract Background Obesity is accompanied by excess adipose fat storage, which may lead to dysfunction, insulin resistance, and type 2 diabetes (T2D). Currently, the tendency develop T2D in obesity cannot be explained genetic variation alone—epigenetic mechanisms, such as DNA methylation, might involved. Here, we aimed identify changes methylation gene expression visceral tissue (VAT) that underlie susceptibility patients with obesity. Methods We investigated VAT biopsies from 19 women...
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Folate deficiency has been related to several conditions, including neural tube defects (NTDs) and cardiovascular diseases. Hence, MTHFR genetic variants have studied worldwide, particularly the C677T A1298C. We genotyped A1298C polymorphisms Mexican Amerindians (MAs), from largest sample included study (n = 2026, 62 ethnic groups), geographically-matched Mestizo population (MEZ, n 638). The 677T allele was...
The function of dystrophin Dp71 in neuronal cells remains to be established. Previously, we revealed the involvement this protein both nerve growth factor (NGF)-induced differentiation and cell adhesion by isolation characterization PC12 with depleted levels Dp71. In work, a novel phenotype Dp71-knockdown was characterized, which is their delayed rate. Cell cycle analyses an altered behavior Dp71-depleted cells, consists delay G0/G1 transition increase apoptosis during nocodazole-induced...
Abstract Background Human Papillomavirus (HPV) E2 plays several important roles in the viral cycle, including transcriptional regulation of oncogenes E6 and E7, genome replication by its association with E1 helicase participates segregation during mitosis cellular protein Brd4. It has been shown that can regulate negative or positively activity promoters, although precise mechanism this is uncertain. In work we constructed a recombinant adenoviral vector to overexpress HPV16 evaluated global...
Inorganic arsenic (iAs), a major environmental contaminant, has risen as an important health problem worldwide. More detailed identification of the molecular mechanisms associated with iAs exposure would help to establish better strategies for prevention and treatment. Although chronic exposures have been previously studied there is little no information regarding early events iAs. To characterize we conducted gene expression studies using sublethal doses at two different time-points. The...
Acute lymphoblastic leukemia (ALL) is a clonal disease that accounts for 20% of acute leukemias in adults. A high percentage adult patients (ranging from 70 to 80%) reach complete remission; however, the 5-year survival rate only 20-40%. One main obstacles treatment success drug resistance leukemic cells. Therefore, our research group analyzed ABCB1 and ABCG2 gene expression levels 61 diagnosed with ALL assessed whether affected clinical parameters 40-month rate.The were using real-time...
OBJECTIVE To assess whether an ethnic-specific variant (p.E508K) in the maturity-onset diabetes of young (MODY) gene hepatocyte nuclear factor-1α (HNF1A) found Mexicans is associated with higher sensitivity to sulfonylureas, as documented patients MODY3. RESEARCH DESIGN AND METHODS We recruited 96 participants (46 carriers and 50 age- sex-matched noncarriers). Response glipizide (one 2.5–5.0-mg dose), metformin (four 500-mg doses), oral glucose challenge was evaluated using a previously...
Acute myeloid leukemia is characterized by its high biological and clinical heterogeneity, which represents an important barrier for a precise disease classification accurate therapy. While epigenetic aberrations play pivotal role in acute pathophysiology, molecular signatures such as change the DNA methylation patterns genetic mutations enzymes needed to process can also be helpful classifying leukemia. Our study aims unveil relevance of DNMT3A TET2 genes global specific Peripheral blood...
Molecular diagnosis of cystic fibrosis (CF) is challenging in Mexico due to the population's high genetic heterogeneity. To date, 46 pathogenic variants (PVs) have been reported, yielding a detection rate 77%. We updated spectrum and frequency PVs responsible for this disease mexican patients.