A5012616417- Gene expression and cancer classification
- Lung Cancer Treatments and Mutations
- Gene Regulatory Network Analysis
- Vector-borne infectious diseases
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Reproductive System and Pregnancy
- Cancer Genomics and Diagnostics
- Bioinformatics and Genomic Networks
- HIV Research and Treatment
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Research on Leishmaniasis Studies
- MicroRNA in disease regulation
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Viral Infections and Vectors
- Trypanosoma species research and implications
- Reproductive Biology and Fertility
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Endometriosis Research and Treatment
- Molecular Biology Techniques and Applications
- Computational Drug Discovery Methods
- Tuberculosis Research and Epidemiology
- Genomics and Chromatin Dynamics
National Institute of Genomic Medicine
2014-2024
Tecnológico de Monterrey
2020-2024
Instituto de Medicina Genómica
2010-2021
Universidad Nacional Autónoma de México
1982-2019
Universidad Veracruzana
2019
University of California, Davis
2019
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2010-2019
Centro Medico Nacional Siglo XXI
2019
Sonora Institute of Technology
2019
Centers for Disease Control and Prevention
2019
Head and neck squamous cell carcinoma (HNSCC) is a common, morbid, frequently lethal malignancy. To uncover its mutational spectrum, we analyzed whole-exome sequencing data from 74 tumor-normal pairs. The majority exhibited profile consistent with tobacco exposure; human papillomavirus was detectable by DNA infected tumors. In addition to identifying previously known HNSCC genes (TP53, CDKN2A, PTEN, PIK3CA, HRAS), our analysis revealed many not implicated in this At least 30% of cases...
Breast carcinoma is the leading cause of cancer-related mortality in women worldwide, with an estimated 1.38 million new cases and 458,000 deaths 2008 alone. This malignancy represents a heterogeneous group tumours characteristic molecular features, prognosis responses to available therapy. Recurrent somatic alterations breast cancer have been described, including mutations copy number alterations, notably ERBB2 amplifications, first successful therapy target defined by genomic aberration....
To gain insight into the genomic basis of diffuse large B-cell lymphoma (DLBCL), we performed massively parallel whole-exome sequencing 55 primary tumor samples from patients with DLBCL and matched normal tissue. We identified recurrent mutations in genes that are well known to be functionally relevant DLBCL, including MYD88 , CARD11 EZH2 CREBBP . also somatic for which a functional role has not been previously suspected. These include MEF2B MLL2 BTG1 GNA13 ACTB P2RY8 PCLO TNFRSF14 Further,...
We have used state-space models (SSMs) to reverse engineer transcriptional networks from highly replicated gene expression profiling time series data obtained a well-established model of T cell activation. SSMs are class dynamic Bayesian in which the observed measurements depend on some hidden state variables that evolve according Markovian dynamics. These can capture effects cannot be directly measured experiment, for example: genes not been included microarray, levels regulatory proteins,...
Abstract Motivation: We have used state-space models to reverse engineer transcriptional networks from highly replicated gene expression profiling time series data obtained a well-established model of T-cell activation. State space are class dynamic Bayesian that assume the observed measurements depend on some hidden state variables evolve according Markovian dynamics. These can capture effects cannot be measured in experiment, e.g. genes not been included microarray, levels regulatory...
Studies of pharmacogenomics-related traits are increasingly being performed to identify loci that affect either drug response or susceptibility adverse reactions. However, the effect polymorphisms can differ in magnitude be absent depending on population assessed. We used Affymetrix Drug Metabolizing Enzymes and Transporters (DMET) Plus array characterize distribution pharmacogenetics pharmacogenomics (PGx) relevance two samples from most populous Latin American countries, Brazil Mexico. The...
Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disease of unknown etiology. A growing body evidence indicates that it may result from an aberrant activation alveolar epithelium, which induces the expansion fibroblast population, their differentiation to myofibroblasts excessive accumulation extracellular matrix. The mechanisms activate epithelium are unknown, but several studies indicate smoking main environmental risk factor for development IPF. In this study we explored...
Leishmania mexicana can cause both localized (LCL) and diffuse (DCL) cutaneous leishmaniasis, yet little is known about factors regulating disease severity in these patients. We analyzed if the was associated with single nucleotide polymorphisms (SNPs) IL-1β (−511), CXCL8 (−251) and/or inhibitor IL-1RA (+2018) 58 Mexican mestizo patients LCL, 6 DCL 123 control cases. Additionally, we vitro production of by monocytes, expression this cytokine sera patients, as well tissue distribution number...
At present, prostate-specific antigen (PSA) is used as a clinical biomarker for prostate cancer (PCa) diagnosis; however, large number of patients with benign hyperplasia (BPH) PSA levels in the 'gray area' (4-10 ng/ml) are currently subjected to unnecessary biopsy due overdiagnosis. Certain microRNAs (miRs) have been proven be useful biomarkers, several which detectable bodily fluids. The present study identified and validated urinary miR‑based signature enhance specificity PCa diagnosis...
Obesity is a well-recognized risk factor for insulin resistance and type 2 diabetes (T2D), although the precise mechanisms underlying relationship remain unknown. In this study we identified alterations of DNA methylation influencing T2D pathogenesis, in subcutaneous visceral adipose tissues, liver, blood from individuals with obesity. The included obesity, without T2D. From these patients, obtained samples liver tissue (n = 16), tissues 30), peripheral 38). We analyzed using Illumina...
Idiopathic pulmonary fibrosis (IPF) is an ageing-related lung disorder characterised by expansion of the myofibroblast population and aberrant remodelling. Dehydroepiandrosterone (DHEA), a steroid pro-hormone, decreases with age but exaggerated decline has been associated chronic degenerative diseases. We quantified plasma levels DHEA its sulfated form (DHEA-S) in 137 IPF patients 58 controls examined effects on human fibroblasts. Plasma DHEA/DHEA-S was significantly decreased male (median...
Seed germination is a critical developmental period for plant propagation. Information regarding gene expression within this important relevant understanding the main biochemical processes required successful germination, particularly in maize, one of most cereals world. The present research focuses on global microarray analysis differential between quiescent and germinated maize embryo stages. This revealed that large number mRNAs stored embryonic axes (QEAs) were differentially regulated...
Regulatory T cells (Tregs) play a crucial role in immune homeostasis. Treg induction is strategy that parasites have evolved to modulate the host’s inflammatory environment, facilitating their establishment and permanence. In human Taenia solium neurocysticercosis (NC), concurrence of increased peripheral central levels capacity inhibit cell activation proliferation support controlling neuroinflammation. This study aimed at identifing possible mechanisms NC. Monocyte-derived dendritic (DC)...
An important NK-cell inhibition with reduced TNF-α, IFN-γ and TLR2 expression had previously been identified in patients diffuse cutaneous leishmaniasis (DCL) infected Leishmania mexicana. In an attempt to pinpoint alterations the signaling pathways responsible for dysfunction DCL, this study aimed at identifying differences response towards mexicana lipophosphoglycan (LPG) between localized through gene profiling. Our results indicate that genes involved innate immune are down-regulated NK...
In 2015, emergent cases of localized cutaneous leishmaniasis (LCL) were reported in Tinum, Yucatan, Mexico. As part an eco-epidemiological study to characterize the elements that trigger Leishmania infection area, we conducted a field investigate occurrence wild rodents. From November 2019 February 2020, rodents caught from three sites located municipality Yucatan. For each specimen, clinical signs suggestive recorded. Samples tail, liver, and spleen taken for identification DNA by PCR....
Tobacco-smoke is the major etiological factor related to lung cancer. However, other important chronic wood smoke exposure (WSE). Approximately 30 % of cancer patients in Mexico have a history WSE, and present different clinical, pathological molecular characteristics compared tobacco cancer, including differences mutational profiles. There are several alterations identified WSE associated however most studies focused on analysis changes pathogenesis proteins.Our group evaluated gene...
Suicide represents a major health concern, especially in developing countries. While many demographic risk factors have been proposed, the underlying molecular pathology of suicide remains poorly understood. A body evidence suggests that aberrant DNA methylation and expression is involved. In this study, we examined profiles concordant gene changes prefrontal cortex Mexicans who died by suicide.In collaboration with coroner's office Mexico City, brain samples males (n = 35) age-matched...