A5037430291- Methane Hydrates and Related Phenomena
- Hydrocarbon exploration and reservoir analysis
- Geology and Paleoclimatology Research
- Geological and Geophysical Studies
- Atmospheric and Environmental Gas Dynamics
- Neuroscience and Neuropharmacology Research
- Prenatal Substance Exposure Effects
- Geomagnetism and Paleomagnetism Studies
- Alcoholism and Thiamine Deficiency
- RNA Research and Splicing
- Geological formations and processes
- Hydraulic Fracturing and Reservoir Analysis
- RNA modifications and cancer
- Phosphodiesterase function and regulation
- Neuroscience of respiration and sleep
- Biochemical Analysis and Sensing Techniques
- Geochemistry and Elemental Analysis
- Geological and Geochemical Analysis
- Alcohol Consumption and Health Effects
- Hearing, Cochlea, Tinnitus, Genetics
- RNA and protein synthesis mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Urinary Bladder and Prostate Research
- Endometriosis Research and Treatment
- Barrier Structure and Function Studies
Woodwell Climate Research Center
2021-2024
United States Geological Survey
2020-2024
The University of Texas at Austin
2017-2022
Brigham Young University
2022
Central Energy Resources Science Center
2021
University of New Hampshire
2010-2021
International Ocean Discovery Program
2016
University of Southampton
2013
Pfizer (United Kingdom)
1995-2011
Pfizer (United States)
2003-2011
Microbial life inhabits deeply buried marine sediments, but the extent of this vast ecosystem remains poorly constrained. Here we provide evidence for existence microbial communities in ~40° to 60°C sediment associated with lignite coal beds at ~1.5 2.5 km below seafloor Pacific Ocean off Japan. methanogenesis was indicated by isotopic compositions methane and carbon dioxide, biomarkers, cultivation data, gas compositions. Concentrations indigenous cells 1.5 ranged from <10 ~10(4) cm(-3)....
Rationale: Phosphodiesterase Type 5 (PDE5) inhibition represents a novel strategy for the treatment of pulmonary hypertension. Objectives: Our aim was to establish distribution PDE5 in vasculature and effects on artery smooth muscle cells (PASMCs). Methods Measurements: expression examined by immunohistochemistry Western blotting, both normal hypertensive lung tissues. DNA synthesis, proliferation, PDE activity, apoptosis were measured distal human PASMCs treated with soluble guanylyl...
We report here the cloning, expression, and characterization of human PDE11A1, a member distinct cyclic nucleotide phosphodiesterase (PDE) family. PDE11A exhibits ≤50% amino acid identity with catalytic domains all other PDEs, being most similar to PDE5, has biochemical properties. The PDE11A1 cDNA isolated contains complete open reading frame encoding 490-amino enzyme predicted molecular mass 55,786 Da. At N terminus single GAF domain homologous that found in signaling molecules, including...
A quantitative histological study was made of the cerebellar vermis in 10 male alcoholic and 8 age-matched control cases. The mean Purkinje cell loss 21% group. small rostral caudal lobes were most severely affected. density per unit length foliae showed similar changes. Histological measurements area molecular, granular medullary layers that molecular layer varied degree shrinkage between (from 11 to 39%) while a consistent (9 10%). appears be vulnerable region chronic alcoholics. Brains...
Phillips S.C. & Cragg B.G. 1982 Neuropathology a id Applied Neurobiology 8, 455–463 A change in susceptibility of rat cerebellar Purkinje cells to damage by acetaldehyde during fetal neonatal and adult life The sensitivity fetal, or has been assessed histological techniques. pregnant female was exposed ethanol vapour the last 2 weeks gestation while metabolism blocked injections disulfiram (200mg/kg) on days E14, E16, E18 E20. were counted offspring 5 after birth. number lobes I VIII 52%...
Phillips S.C. & Cragg B.G.1982 Neuropathology and Applied Neurobiology 8, 441–454 A change in susceptibility of rat cerebellar Purkinje cells to damage by alcohol during fetal, neonatal adult life The sensitivity ethanol exposure or was assessed histological techniques. Pregnant female rats were exposed vapour the last 2 weeks gestation. counted 5 days after pups born. number lobe VIII reduced 45%, linear density I 47% less than controls not ethanol. Smaller reductions found other lobes....
This study aimed to classify the responses of single units in auditory midbrain acoustic stimuli presented free field order characterize those likely have a role sound localization horizontal plane. The 131 inferior colliculus cat and brush-tailed possum were studied using tone noise-burst from speaker capable movement at any point along plane 10 degrees above Speaker positions this are referred as azimuths; on same side recorded ipsilateral, opposite contralateral, azimuths. For each unit,...
Soil carbon dioxide efflux (soil respiration, SR) was measured with eight autochambers at two locations along a wetland to upland slope Harvard Forest over 4 year period, 2003–2007. SR consistently higher in the plots than margin during late summer/early fall. Seasonal and diel hystereses respect soil temperatures were of sufficient magnitude prevent quantification influence moisture, although apparent short‐term responses precipitation occurred. Calculations annual cumulative illustrated...
Abstract Ebullition (bubbling) from climate‐sensitive northern lakes remains an unconstrained source of atmospheric methane (CH 4 ). Although the focus many recent studies, ebullition is rarely linked to physical characteristics lakes. In this study we analyze sediments subarctic postglacial and investigate how sediment properties relate large spatial variation in CH bubble flux, quantified over multiple years using traps. The results show that our are rich total organic carbon, containing...
The University of Texas Hydrate Pressure Coring Expedition (UT-GOM2-1) recovered cores at near in situ formation pressures from a gas hydrate reservoir composed sandy silt and clayey beds Green Canyon Block 955 the deep-water Gulf Mexico. expedition results are synthesized linked to other detailed analyses presented this volume. Millimeter- meter-scale interbedded on levee turbidite channel. saturation (the volume fraction pore space occupied by hydrate) silts ranges 79% 93%, there is little...
Phosphodiesterase 11A (PDE11A) is a recently identified family of cAMP and cGMP hydrolyzing enzymes. Thus far, single splice variant designated as PDE11A1 has been reported. In this study, we identify characterize two additional variants PDE11A, PDE11A2 PDE11A3. The full-length cDNAs are 2,141 bp for 2205 ORF predicts protein 576 aa with molecular mass 65.8 kDa. PDE11A3 684 78.1 Comparison the sequence that indicates an 86 at N terminus PDE11A2. Part extends potential binding region (GAF...
The responses to changes in stimulus azimuth of 204 neurons the inferior colliculus cat with best frequencies less than 3 kHz were studied. Three main unit classes identified: omnidirectional units uninfluenced by speaker (39%); multipeaked several azimuthal regions at which peak firing occurred (9%); and azimuth-selective that showed clear preferences for a discrete range sound-source azimuths (52%). Alterations intensity produced little change shapes profiles relating rate (azimuth...
Abstract Much is known of the sources and manner termination ascending descending input to inferior colliculus (IC) but its commissural connections are less well understood. Most studies commissure have utilized small lesions or tracer deposits; while all agree that axons terminating in IC do so superficial dorsomedial sectors, it not clear where projecting cell bodies located IC. The present study attempted total infiltration cat with horseradish peroxidase (HRP) an effort label neuronal...