A5086060975- Cannabis and Cannabinoid Research
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Diagnosis and Treatment of Venous Diseases
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Venous Thromboembolism Diagnosis and Management
- Central Venous Catheters and Hemodialysis
- Neuroscience and Neuropharmacology Research
- Hereditary Neurological Disorders
- Chemical synthesis and alkaloids
- Calpain Protease Function and Regulation
- Melanoma and MAPK Pathways
- Pharmacology and Obesity Treatment
- Diet and metabolism studies
- Cancer Genomics and Diagnostics
- PARP inhibition in cancer therapy
- Genomics, phytochemicals, and oxidative stress
- Cancer, Stress, Anesthesia, and Immune Response
- RNA regulation and disease
- Gene expression and cancer classification
- Tannin, Tannase and Anticancer Activities
- Brain Metastases and Treatment
- Lung Cancer Research Studies
Instituto Nacional de Cancerología
2016-2025
Instituto Nacional de Cancerología
2020-2024
Universidad Nacional Autónoma de México
2004
Abstract Background and purpose Chloroquine (CLQ), an antimalarial drug, has a lysosomotropic effect associated with increased radiationsensibility, which is mediated by the leakage of hydrolytic enzymes, apoptosis, autophagy oxidative stress in vitro . In this phase II study, we evaluated efficacy safety radiosensibilization using CLQ concomitant 30 Gray (Gy) whole-brain irradiation (WBI) to treat patients brain metastases (BM) from solid tumors. Methods Seventy-three eligible were...
Gastric cancer is one of the most common forms worldwide. A growing number studies have addressed anti-proliferative effects cannabinoids on several tumor cells. The molecular mechanisms underlying endogenous cannabinoid anandamide (AEA) gastric cell lines yet to be characterized. Here, we investigated elicited by AEA AGS human line employing an Oncoprint database, Western blotting, and immunofluorescence. We observed that (5 µM) inhibited phosphorylated AKT's expression level. This point...
Tobacco-smoke is the major etiological factor related to lung cancer. However, other important chronic wood smoke exposure (WSE). Approximately 30 % of cancer patients in Mexico have a history WSE, and present different clinical, pathological molecular characteristics compared tobacco cancer, including differences mutational profiles. There are several alterations identified WSE associated however most studies focused on analysis changes pathogenesis proteins.Our group evaluated gene...
Lung cancer (LC) and pulmonary tuberculosis (TB) are the deadliest neoplastic bacterial infectious diseases worldwide, respectively. Clinicians pathologists have long discussed co-existence of LC TB, several epidemiologic studies presented evidence indicating that TB could be associated with development LC, particularly adenocarcinoma. Nonetheless, this data remains controversial, mechanism which underlie association largely unexplored. Some bioinformatic shown human biopsies a very high...
Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous disease. Seven subtypes have been described based on gene expression patterns. Herein, we characterized the tumor biology clinical behavior of immunomodulatory (IM) subtype. Methods: Formalin-fixed paraffin-embedded samples from 68 high-risk (stage III-IV) TNBC patients were analyzed through microarrays, immunohistochemistry, DNA sequencing. Results: The IM subtype was identified in 24% by a higher intratumoral (intT)...
Triple negative breast cancer (TNBC) is an aggressive type of that accounts for ~23% tumors in Mexico. In attempt to understand improved way the behavior TNBC, throughout years, gene expression these has been studied. Lehman et al identified 6 subtypes TNBC with distinct characteristics. present study, it was aimed assess clinical, pathological and prognostic characteristics a Mexican-based cohort. A total 55 patients diagnosed at Mexico's National Institute Cancer (INCan) were included....
Intimal hyperplasia is the response to endothelial injury. Platelet-derived growth factor released early and favors formation of intimal hyperplasia. Although multiple treatments, from open surgery endovascular techniques, have been used they remain controversial. There currently interest in developing pharmacological strategies address this pathology. Local vascular inflammation induced by vessel barotrauma generates due mechanical stress over venous endothelium. Cilostazol a selective...
Los enteógenos han surgido en la investigación clínica como un tratamiento alternativo para Depresión Resistente al Tratamiento (DRT). Tienen efectos antidepresivos rápidos y duraderos, son ansiolíticos, mitigan ideación suicida. Además, inducen emociones positivas provocan experiencias místicas o espirituales, atributos que pueden contribuir a su eficacia terapéutica, dada influencia protectora del misticismo religiosidad contra depresión. Esta revisión narrativa tiene objetivo discutir...
Background : Trastuzumab resistance is associated with overexpressing the human epidermal growth factor receptor 2 (HER‐2), which results from altered phosphoinositide 3‐kinase (PI3K) pathway in breast cancer patients. Objective We quantified frequency of PI3K enzyme single and double‐point mutations Mexican patients HER‐2 its association clinical‐pathological variables. Methods embedded samples paraffin 60 patients, extracted their DNA, evaluated 49 HER‐2‐positive tumors. focused on for one...
ResumenObjetivo: La hiperplasia intimal del endotelio venoso es una de las principales causas trombosis en reconstrucciones vasculares.Este proceso patológico se define como la respuesta celular y molecular caracterizada por proliferación anormal células musculares lisas.Se ha descrito asociación importante con señales tróficas, algunas asociadas a factores crecimiento el factor derivado plaquetas.Dichos mecanismos iniciadores aún no han sido bien caracterizados nivel molecular.La...
Abstract Rectal cancer is considered a major health issue in several countries that present advanced and metastatic stages limited response to standard treatments. Though the antineoplasic activity of cannabinoids has been documented studies, scarce information available about effect these agents cell lines rectal cancer. In this work, we explored antiproliferative effects cannabinoid receptor agonists tumor cells. The three anandamide, methanandamide CP55940 were evaluated SW837 line....
Background:The arteriovenous fistula (AVF) is the first option as vascular access for patients with end-stage renal disease.The main cause of failure stenosis venous portion AVF secondary to intimal hyperplasia.Material and methods: The objective this study was evaluate relative expression miR-145, miR-146, miR-155.We used an experimental model hyperplasia creating AVF.We included six Wistar Rats.The analysis validation miR-155 performed using real-time polymerase chain reaction.Results:...