A5046400529- Cervical Cancer and HPV Research
- Cancer-related molecular mechanisms research
- Hepatitis B Virus Studies
- interferon and immune responses
- T-cell and Retrovirus Studies
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Virus-based gene therapy research
- Nanoplatforms for cancer theranostics
- Wnt/β-catenin signaling in development and cancer
- Helicobacter pylori-related gastroenterology studies
- Monoclonal and Polyclonal Antibodies Research
- Genital Health and Disease
- Epigenetics and DNA Methylation
- Head and Neck Cancer Studies
- Molecular Biology Techniques and Applications
- MicroRNA in disease regulation
- Viral Infections and Vectors
- Veterinary Oncology Research
- Advanced Nanomaterials in Catalysis
- Advanced Photocatalysis Techniques
- Glutathione Transferases and Polymorphisms
- T-cell and B-cell Immunology
- Ferroptosis and cancer prognosis
- Hedgehog Signaling Pathway Studies
Benemérita Universidad Autónoma de Puebla
2011-2025
Instituto Nacional de Cancerología
2014-2023
Consejo Nacional de Humanidades, Ciencias y Tecnologías
2020-2023
Universidad Nacional Autónoma de México
2013-2022
Instituto Nacional de Cancerología
2022
Secretaria de Salud
2018
Instituto Nacional de Salud Pública
2018
International Centre for Genetic Engineering and Biotechnology
2013
Oxidative stress has been proposed as a risk factor for cervical cancer development. However, few studies have evaluated the redox state associated with human papillomavirus (HPV) infection. The aim of this work was to determine role early expressed viral proteins E1, E2, E6 and E7 from HPV types 16 18 in modulation an integral form. Therefore, generation reactive oxygen species (ROS), concentration reduced glutathione (GSH), levels activity antioxidant enzymes catalase superoxide dismutase...
A subset of high-risk Human Papillomaviruses (HPVs) are the causative agents a large number human cancers, which cervical is most common. Two viral oncoproteins, E6 and E7, contribute directly towards development maintenance malignancy. characteristic feature oncoproteins from cancer-causing HPV types presence PDZ binding motif (PBM) at its C-terminus, confers interaction with cellular proteins harbouring domains. Here we show that this allows Sorting Nexin 27 (SNX27), an essential component...
Abstract The Human Papillomavirus (HPV) E1 protein is the only viral with enzymatic activity. main known function of this regulation DNA replication. Nevertheless, it has been demonstrated that ablation HPV18 mRNA in HeLa cells promotes a deregulation several genes, particularly those involved host defense mechanisms against infections; however, specific contribution HPV-independent context not studied. aim work was to determine effect HPV cellular gene expression profiles evaluated through...
<i>Azotobacter vinelandii </i>is a soil bacterium that produces the polysaccharide alginate. The two-component system GacS/GacA is required for alginate synthesis since mutation in <i>gacS </i>or <i>gacA </i>significantly reduced level of transcripts <i>algD</i>, gene encoding GDP-mannose dehydrogenase, key enzyme biosynthetic pathway. In many γ-proteobacteria, GacA homologs control expression small regulatory RNAs RsmZ/Y/X (CsrB/CsrC) family...
Gastric cancer is one of the most common forms worldwide. A growing number studies have addressed anti-proliferative effects cannabinoids on several tumor cells. The molecular mechanisms underlying endogenous cannabinoid anandamide (AEA) gastric cell lines yet to be characterized. Here, we investigated elicited by AEA AGS human line employing an Oncoprint database, Western blotting, and immunofluorescence. We observed that (5 µM) inhibited phosphorylated AKT's expression level. This point...
COVID-19 was the leading cause of death in Mexico between 2020 and 2021. SARS-CoV-2 infection varies widely among individuals populations. Since variations genes related to immune response may play a role susceptibility outcome COVID-19, associations gene polymorphisms (SNPs) IL-6 (- 573G > C, rs1800796), TNF-α 308G A, rs1800629), IFN-γ 1615 C T, rs2069705) with expression levels these proteins nasopharynx serum were evaluated Mexican population mild, severe, or critical COVID-19. A total...
Persistent high-risk human papillomavirus infection is the main risk factor for cervical cancer establishment, where viral oncogenes E6 and E7 promote a cancerous phenotype. Metabolic reprogramming in involves alterations glutamine metabolism, also named glutaminolysis, to provide energy supporting processes including migration, proliferation, production of reactive oxygen species, among others. The aim this work was analyze effect HPV16 oncoproteins on regulation glutaminolysis its...
Nanometric materials with biocidal properties effective against severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and pathogenic bacteria could be used to modify surfaces, reducing the risk of touching transmission. In this work, we showed that a nanometric layer bimetallic AgCu can effectively deposited on polypropylene (PP) fibers. The virucidal nanofilm were evaluated by comparing viral loads remaining uncoated coated PP after contact times between 2 24 h. Quantification virion...
The Wnt/β-catenin signaling pathway regulates cell proliferation and differentiation its aberrant activation in cervical cancer has been described. Persistent infection with high risk human papillomavirus (HR-HPV) is the most important factor for development of this neoplasia, since E6 E7 viral oncoproteins alter cellular processes, promoting development. A role HPV-16 proposed, although participation HPV-18 not previously studied. aim work was to investigate E6*I, regulation pathway. Here,...
Helicobacter pylori is a Gram-negative bacterium that causes chronic atrophic gastritis and peptic ulcers it has been associated with the development of gastric adenocarcinoma mucosa-associated lymphoid tissue (MALT). One more remarkable characteristics H. its ability to survive in hostile environment stomach. regulates expression specific sets genes allowing high acidity levels nutrient scarcity. In present study, we determined virulence protein D (VapD) inside (AGS) cells biopsies. Using...
Persistent infection with high-risk Human Papillomavirus (HR-HPV) is the main requisite for cervical cancer development. Normally, HPV limited to site of and regulates a plethora cellular elements avoid immune surveillance by inducing an anti-inflammatory state, allowing progress through viral cycle carcinogenic process. Recent findings suggest that AT-hook transcriptional factor AKNA could play role in development cancer. strongly related expression co-stimulatory molecules such CD40/CD40L...