A5003412190- Acute Lymphoblastic Leukemia research
- Metabolism, Diabetes, and Cancer
- Drug Transport and Resistance Mechanisms
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Childhood Cancer Survivors' Quality of Life
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cancer, Hypoxia, and Metabolism
- Pharmaceutical studies and practices
- MicroRNA in disease regulation
- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- Liver Disease Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- RNA Interference and Gene Delivery
- Glioma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
Dana-Farber Cancer Institute
2024
Hospital General de México
2013-2020
Acute lymphoblastic leukemia (ALL) is a clonal disease that accounts for 20% of acute leukemias in adults. A high percentage adult patients (ranging from 70 to 80%) reach complete remission; however, the 5-year survival rate only 20-40%. One main obstacles treatment success drug resistance leukemic cells. Therefore, our research group analyzed ABCB1 and ABCG2 gene expression levels 61 diagnosed with ALL assessed whether affected clinical parameters 40-month rate.The were using real-time...
Approximately 40-50% of patients with acute myeloid leukaemia (AML) have been reported to present a normal karyotype and variable disease-free period, most likely due the molecular heterogeneity presented by these patients. A variety mutations identified at level, such as those in IDH1/2 gene, which causes gain function isocitrate dehydrogenase enzyme, generating high levels (R)-2-hydroxyglutarate oncometabolite, competitively inhibits dioxygenase enzymes. Therefore, objective this study was...
Abstract Background Haematologic malignancies are generated by alterations in haematopoietic stem cells. Chromosomal rearrangements present >50% of patients and useful as diagnostic prognostic factors. Objective In this study we describe the cytogenetic characteristics observed with haematological Genetics Department during period 2000–2014. Material Methods The karyotype was performed on bone marrow (85%) peripheral blood (15%) conventional techniques 9717 samples. Results average age 40...
Background: Metformin has antineoplastic and cancer protective effects in vitro, sensitizing leukemia cells to chemotherapeutic agents, inducing apoptosis cell cycle arrest.
Abstract The understanding of the somatic driver mutations and genetic abnormalities in acute myeloid leukemia (AML) has enabled discovery actionable improved risk stratification; however, it is unclear how distribution molecular defined subsets varies within different populations. median age AML diagnosis Mexico younger than for other international cohorts; no mutational analysis been performed to date. We thus sought ascertain differences this population. Methods: created a collaborative...