Brian E. Cade
A5020527623- Genetic Associations and Epidemiology
- Obstructive Sleep Apnea Research
- Sleep and related disorders
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Genomics and Rare Diseases
- Obesity, Physical Activity, Diet
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Sleep and Work-Related Fatigue
- Bioinformatics and Genomic Networks
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Circadian rhythm and melatonin
- Nutrition, Genetics, and Disease
- Cardiovascular Health and Risk Factors
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lipid metabolism and disorders
- Asthma and respiratory diseases
- Acute Myeloid Leukemia Research
- Hospital Admissions and Outcomes
- RNA Research and Splicing
Circadian (United States)
2016-2025
Brigham and Women's Hospital
2016-2025
Broad Institute
2018-2025
Harvard University
2016-2025
Harvard University Press
2006-2023
Beth Israel Deaconess Medical Center
2021
University of Bristol
2018
SleepMed
2001-2016
Canadian Sleep & Circadian Network
2015-2016
Fealinx (France)
2016
Abstract The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic architecture and biology of heart, lung, blood sleep disorders, with ultimate goal improving diagnosis, treatment prevention these diseases. initial phases focused on whole-genome sequencing individuals rich phenotypic data diverse backgrounds. Here we describe TOPMed goals design as well available resources early insights obtained from sequence data. include a variant browser, genotype...
Long work hours and shifts of an extended duration (> or =24 hours) remain a hallmark medical education in the United States. Yet their effect on health safety has not been evaluated with use validated measures.We conducted prospective nationwide, Web-based survey which 2737 residents first postgraduate year (interns) completed 17,003 monthly reports that provided detailed information about hours, duration, documented motor vehicle crashes, near-miss incidents, incidents involving...
Knowledge of the physiological effects extended (24 hours or more) work shifts in postgraduate medical training is limited. We aimed to quantify hours, sleep, and attentional failures among first-year residents (postgraduate year 1) during a traditional rotation schedule that included an intervention limited scheduled 16 fewer consecutive hours.
Abstract Sleep is an essential state of decreased activity and alertness but molecular factors regulating sleep duration remain unknown. Through genome-wide association analysis in 446,118 adults European ancestry from the UK Biobank, we identify 78 loci for self-reported habitual ( p < 5 × 10 −8 ; 43 at 6 −9 ). Replication observed PAX8 , VRK2 FBXL12/UBL5/PIN1 CHARGE study n = 47,180; 6.3 −4 ), 55 signals show sign-concordant effects. The further associate with accelerometer-derived...
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes
In their first year of postgraduate training, interns commonly work shifts that are longer than 24 hours. Extended-duration associated with increased risks automobile crash, particularly during a commute from work. Interns may be at risk for other occupation-related injuries.To assess the relationship between extended duration and rates percutaneous injuries in diverse population United States.National prospective cohort study 2737 estimated 18,447 US residency programs July 2002 through May...
<h3>Context</h3>Sleep disorders often remain undiagnosed. Untreated sleep among police officers may adversely affect their health and safety pose a risk to the public.<h3>Objective</h3>To quantify associations between disorder self-reported health, safety, performance outcomes in officers.<h3>Design, Setting, Participants</h3>Cross-sectional prospective cohort study of North American participating either an online or on-site screening (n=4957) monthly follow-up surveys (n=3545 representing...
Abstract Sleep spindles are characteristic electroencephalogram (EEG) signatures of stage 2 non-rapid eye movement sleep. Implicated in sleep regulation and cognitive functioning, may represent heritable biomarkers neuropsychiatric disease. Here we characterize 11,630 individuals aged 4 to 97 years, as a prelude future genetic studies. Spindle properties highly reliable but exhibit distinct developmental trajectories. Across the night, observe complex patterns age- frequency-dependent...
Tobacco and alcohol use are heritable behaviours associated with 15% 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease injury1-4. These substances used across the globe, yet genome-wide association studies have focused on individuals European ancestries5. Here we leveraged global genetic diversity 3.4 million from four major clines ancestry (approximately 21% non-European) power discovery fine-mapping genomic loci tobacco use, inform function these via...
Summary paragraph The Trans-Omics for Precision Medicine (TOPMed) program seeks to elucidate the genetic architecture and disease biology of heart, lung, blood, sleep disorders, with ultimate goal improving diagnosis, treatment, prevention. initial phases focus on whole genome sequencing individuals rich phenotypic data diverse backgrounds. Here, we describe TOPMed goals design as well resources early insights from sequence data. include a variant browser, genotype imputation panel, sharing...
Abstract Chronic obstructive pulmonary disease (COPD) is associated with age and smoking, but other determinants of the are incompletely understood. Clonal hematopoiesis indeterminate potential (CHIP) a common, age-related state in which somatic mutations clonal blood populations induce aberrant inflammatory responses. Patients CHIP have an elevated risk for cardiovascular disease, association COPD remains unclear. We analyzed whole-genome sequencing whole-exome data to detect 48 835...
Abstract Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes 1,2 and molecular mechanisms are often specific to cell type 3,4 . Here, characterize the genetic contribution these across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases T2D. We identify 1,289 independent signals at significance ( P < 5 × 10 −8 ) map 611 loci, which 145...
Obstructive sleep apnea is a common disorder associated with increased risk for cardiovascular disease, diabetes, and premature mortality. Although there strong clinical epidemiologic evidence supporting the importance of genetic factors in influencing obstructive apnea, its basis still largely unknown. Prior studies focused on traits defined using apnea-hypopnea index, which contains limited information potentially important genetically determined physiologic factors, such as propensity...