A5032516013- Health and Lifestyle Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lipoproteins and Cardiovascular Health
- Obesity, Physical Activity, Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Vitamin D Research Studies
- Neonatal Respiratory Health Research
- Adipose Tissue and Metabolism
- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Cardiovascular Function and Risk Factors
- Diabetes and associated disorders
- Cardiac Imaging and Diagnostics
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Pediatric health and respiratory diseases
- Thyroid Disorders and Treatments
- Aging, Health, and Disability
- Nutrition, Genetics, and Disease
- Global Public Health Policies and Epidemiology
- Regulation of Appetite and Obesity
- Protease and Inhibitor Mechanisms
- Advanced X-ray and CT Imaging
- Diet and metabolism studies
Baylor College of Medicine
2022-2025
Harvard University
2015-2024
Brigham and Women's Hospital
2015-2024
Pontificia Universidad Católica de Chile
2024
University of Zulia
2011-2021
Pulmonary and Critical Care Associates
2018-2021
Harvard University Press
2015-2019
Manchester University NHS Foundation Trust
2018
Medicines Evaluation Unit
2018
University of the Andes
1998-2017
Abstract Chronic obstructive pulmonary disease (COPD) is associated with age and smoking, but other determinants of the are incompletely understood. Clonal hematopoiesis indeterminate potential (CHIP) a common, age-related state in which somatic mutations clonal blood populations induce aberrant inflammatory responses. Patients CHIP have an elevated risk for cardiovascular disease, association COPD remains unclear. We analyzed whole-genome sequencing whole-exome data to detect 48 835...
Rationale: Cigarette smoke (CS) inhalation triggers oxidative stress and inflammation, leading to accelerated lung aging, apoptosis, emphysema, as well systemic pathologies. Metformin is beneficial for protecting against aging-related diseases. Objectives: We sought investigate whether metformin may ameliorate CS-induced pathologies of emphysematous chronic obstructive pulmonary disease (COPD). Methods: Mice were exposed chronically CS fed metformin-enriched chow the second half exposure....
Chimeric antigen receptor T cell (CAR cell) therapy has emerged as a prominent adoptive and therapeutic approach of great interest in the fight against cancer. This shown notorious efficacy refractory hematological neoplasm, which bolstered its exploration field solid cancers. However, successfully managing tumors presents considerable intrinsic challenges, include necessity guiding modified cells toward tumoral region, assuring their penetration survival adverse microenvironments,...
Rationale: CC16 (club cell secretory protein-16), a member of the secretoglobin family, is one most abundant proteins in normal airway secretions and has been described as serum biomarker for obstructive lung diseases.Objectives: To determine whether low marker pathology or implicated pathophysiology progressive damage these conditions.Methods: Using human data from birth cohort Tucson Children's Respiratory Study, we examined relation circulating levels with pulmonary function responses to...
Vitamin D possesses immunomodulatory functions and vitamin deficiency has been associated with the rise in chronic inflammatory diseases, including asthma (Litonjua Weiss, 2007). supplementation studies do not provide insight into molecular genetic mechanisms of D-mediated immunoregulation. Here, we evidence for regulation two human chromosomal loci, Chr17q12-21.1 Chr17q21.2, reliably autoimmune diseases. We demonstrate increased receptor ( Vdr ) expression mouse lung CD4+ Th2 cells,...
Background. Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous condition. We hypothesized that the unbiased integration of different COPD lung omics using novel multi-layer approach may unravel mechanisms associated with clinical characteristics. Methods. profiled mRNA, miRNA and methylome in tissue samples from 135 former smokers COPD. For each omic (layer) we built patient network based on molecular similarity. The three networks were used to build network, optimization...
Type 2 diabetes mellitus and obesity are the most frequent endocrine-metabolic diseases in world their pathogenic basis characterized by insulin resistance secretion defects that can be demonstrated through several alterations carbohydrates, lipids, protein metabolism. The peroxisome proliferator-activated receptors have been identified as key regulators of glucose lipid metabolism, because they act transcription factors stimulate synthesis a wide variety processes (energetic proliferation,...
Background and Aim . Insulin resistance (IR) is a prominent pathophysiologic component in myriad of metabolic disorders, including obesity, prediabetes, type 2 diabetes mellitus, which are common our locality. The objective this study was to determine the prevalence IR factors associated with condition an adult population from Maracaibo city, Venezuela. Methodology A cross-sectional, descriptive multistaged randomized sampling carried out 2026 adults. defined as HOMA2-IR ≥ 2. multiple...
Within chronic obstructive pulmonary disease (COPD), emphysema is characterized by a significant yet partially understood B cell immune component.
Vessel Plus is an open acccess journal, which publishes articles related to vascular diseases, including acute respiratory distress syndrome, aneurysm, atherosclerosis, hypertension, stroke, peripheral or pulmonary etc.
Matrix metalloproteinase-9 (MMP-9) cleaves various proteins to regulate inflammatory and injury responses. However, MMP-9's activities during influenza A viral (IAV) infections are incompletely understood. Herein, plasma MMP-9 levels were increased in patients with pandemic H1N1 seasonal IAV infections. lung localized airway epithelial cells leukocytes H1N1-infected WT murine lungs. Mmp-9-/- mice had lower mortality rates, reduced weight loss, titers, injury, along E-cadherin shedding...
Background: Insulin resistance (IR) evaluation is a fundamental goal in clinical and epidemiological research. However, the most widely used methods are difficult to apply populations with low incomes. The triglyceride-glucose index (TGI) emerges as an alternative use daily practice. Therefore objective of this study was determine optimal cutoff point for TGI adult population from Maracaibo, Venezuela. Methods: This sub-study Maracaibo City Metabolic Syndrome Prevalence Study, descriptive,...
Abstract Programmed Death Ligand 1 (PD-L1) is crucial in regulating the immunological tolerance non-small cell lung cancer (NSCLC). Alveolar macrophage (AM)-derived PD-L1 binds to its receptor, PD-1, on surveilling lymphocytes, leading lymphocyte exhaustion. Increased expression associated with cigarette smoke (CS)-exposure. However, role CS-associated diseases NSCLC, such as chronic obstructive pulmonary disease (COPD), still unclear. In two different cohorts of ever smokers COPD or and...