Toomas Haller
A5026827013- Genetic Associations and Epidemiology
- Ophthalmology and Visual Impairment Studies
- Nutrition, Genetics, and Disease
- Genetic Mapping and Diversity in Plants and Animals
- Metabolomics and Mass Spectrometry Studies
- Retinal Diseases and Treatments
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Corneal surgery and disorders
- Genetic and phenotypic traits in livestock
- Cardiovascular Health and Risk Factors
- Liver Disease Diagnosis and Treatment
- Gout, Hyperuricemia, Uric Acid
- Obesity, Physical Activity, Diet
- Glaucoma and retinal disorders
- Alcohol Consumption and Health Effects
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Health, Environment, Cognitive Aging
- Epigenetics and DNA Methylation
- Genetics and Physical Performance
- Autoimmune and Inflammatory Disorders Research
- Treatment of Major Depression
- Glycosylation and Glycoproteins Research
- Genetic Syndromes and Imprinting
University of Tartu
2016-2025
UK Biobank
2021
ORCID
2021
Cardiff University
2020
Medizinische Hochschule Hannover
2015
Genome-wide association studies have identified numerous loci linked with complex diseases, for which the molecular mechanisms remain largely unclear. Comprehensive profiling of circulating metabolites captures highly heritable traits, can help to uncover metabolic pathophysiology underlying established disease variants. We conduct an extended genome-wide study genetic influences on 123 traits quantified by nuclear magnetic resonance metabolomics from up 24,925 individuals and identify eight...
The Estonian Biobank cohort is a volunteer-based sample of the resident adult population (aged ≥18 years). current number participants—close to 52000-—represents large proportion, 5%, population, making it ideally suited population-based studies. General practitioners (GPs) and medical personnel in special recruitment offices have recruited participants throughout country. At baseline, GPs performed standardized health examination participants, who also donated blood samples for DNA, white...
In this study, Würtz and colleagues conducted high-throughput profiling of blood specimens in two large population-based cohorts order to identify biomarkers for all-cause mortality enhance risk prediction. The authors found that biomarker improved prediction the short-term death from all causes above established factors. However, further investigations are needed clarify biological mechanisms utility these guide screening prevention. Please see later article Editors' Summary
Tobacco and alcohol use are heritable behaviours associated with 15% 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease injury1-4. These substances used across the globe, yet genome-wide association studies have focused on individuals European ancestries5. Here we leveraged global genetic diversity 3.4 million from four major clines ancestry (approximately 21% non-European) power discovery fine-mapping genomic loci tobacco use, inform function these via...
Abstract Introduction Identifying circulating metabolites that are associated with cognition and dementia may improve our understanding of the pathogenesis provide crucial readouts for preventive therapeutic interventions. Methods We studied 299 in relation to (general cognitive ability) two discovery cohorts (N total = 5658). Metabolites significantly after adjusting multiple testing were replicated four independent 6652), associations Alzheimer's disease 25,872) lifestyle factors 5168)...
Abstract Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism 1–7 . This detailed knowledge genetic determinants systemic has been pivotal for uncovering how pathways influence biological mechanisms and complex diseases 8–11 Here we present a genome-wide study 233 circulating metabolic traits quantified by nuclear magnetic resonance spectroscopy in up 136,016 participants from 33 cohorts. We identify...
OBJECTIVE Metformin is used as a first-line oral treatment for type 2 diabetes (T2D). However, the underlying mechanism not fully understood. Here, we aimed to comprehensively investigate pleiotropic effects of metformin. RESEARCH DESIGN AND METHODS We analyzed both metabolomic and genomic data population-based KORA cohort. To evaluate effect metformin on metabolite concentrations, quantified 131 metabolites in fasting serum samples multivariable linear regression models three independent...
Abstract Polygenic Scores (PSs) describe the genetic component of an individual’s quantitative phenotype or their susceptibility to diseases with a basis. Currently, PSs rely on population-dependent contributions many associated alleles, limited applicability understudied populations and recently admixed individuals. Here we introduce combination local ancestry deconvolution partial PS computation account for population-specific nature association signals in individuals ancestry. We...
Abstract Using targeted NMR spectroscopy of 227 fasting serum metabolic traits, we searched for novel signatures renal function in 926 type 2 diabetics (T2D) and 4838 non-diabetic individuals from four independent cohorts. We furthermore investigated longitudinal changes measures associations with other T2D microvascular complications. 142 traits correlated glomerular filtration rate (eGFR) after adjusting confounders multiple testing: 59 diabetics, 109 non-diabetics 26 overlapping. The...
<h3>Importance</h3> Uncertainty currently exists about whether the same genetic variants are associated with susceptibility to low myopia (LM) and high (HM) hyperopia. Addressing this question is fundamental understanding genetics of refractive error has clinical relevance for genotype-based prediction children at risk HM identification new therapeutic targets. <h3>Objective</h3> To assess a common set HM, LM, <h3>Design, Setting, Participants</h3> This association study assessed unrelated...