A5049463882- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Retinal and Macular Surgery
- Ocular Diseases and Behçet’s Syndrome
- Retinal Development and Disorders
- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Optical Coherence Tomography Applications
- Vascular Malformations Diagnosis and Treatment
- Ophthalmology and Eye Disorders
- Cerebral Venous Sinus Thrombosis
- Systemic Lupus Erythematosus Research
- Cell Adhesion Molecules Research
- Acute Ischemic Stroke Management
- Ocular Oncology and Treatments
- Optical Imaging and Spectroscopy Techniques
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ocular Surface and Contact Lens
- Retinopathy of Prematurity Studies
- Platelet Disorders and Treatments
- Angiogenesis and VEGF in Cancer
- Photoreceptor and optogenetics research
Kyoto University
2016-2025
Japan Society for the Promotion of Science
2012-2023
Kyoto University Hospital
2019-2023
Santen (Japan)
2016-2022
Canon (Japan)
2016-2022
Chugai Pharma (United States)
2022
Senju Pharmaceutical (United States)
2022
Wakamoto Pharmaceutical (Japan)
2022
Otsuka (Japan)
2022
Senju Pharmaceutical (Japan)
2022
To study the choroidal thickness in healthy subjects by swept-source optical coherence tomography (SS-OCT) at longer wavelength.The macular area of 31 eyes (31 volunteers) was studied with an SS-OCT prototype system, which uses a tunable laser as light source operated 100,000 Hz A scan repetition rate 1-μm wavelength region. Three-dimensional volumetric measurement comprised 512 × 128 scans acquired 0.8 second. From series OCT images, chroidal map created manual segmentation. evaluate...
To investigate the relationship between subfoveal choroidal thickness, vascular hyperpermeability, and complement factor H (CFH) gene polymorphism in typical age-related macular degeneration (AMD) polypoidal vasculopathy (PCV).Fifty-eight patients with AMD 63 PCV underwent fluorescein angiography, indocyanine green angiography (IA), spectral-domain optical coherence tomography (OCT) using enhanced depth imaging (EDI). Subfoveal thickness was measured EDI-OCT images, hyperpermeability...
Abstract Age-related macular degeneration (AMD) is a major cause of blindness, but presents differently in Europeans and Asians. Here, we perform genome-wide exome-wide association study on 2,119 patients with exudative AMD 5,691 controls, independent replication 4,226 10,289 all East Asian descent, as part The Genetics Asians (GAMA) Consortium. We find strong between CETP Asp442Gly (rs2303790), an Asian-specific mutation, increased risk (odds ratio (OR)=1.70, P =5.60 × 10 −22 ). allele...
Abstract Pachychoroid neovasculopathy is a recently proposed clinical entity of choroidal neovascularization (CNV). As it often masquerades as neovascular age-related macular degeneration (AMD), currently controversial whether pachychoroid should be distinguished from AMD. This because its characteristics have yet to well described. To estimate the relative prevalence in comparison with AMD and investigate phenotypic/genetic differences two diseases, we evaluated 200 consecutive Japanese...
To evaluate the clinical features and risk factors of hemorrhagic complications in eyes with polypoidal choroidal vasculopathy (PCV) after photodynamic therapy (PDT).We retrospectively reviewed data for 91 consecutive 85 patients who underwent PDT treatment PCV. The diagnosis PCV was based on indocyanine green angiographic findings, showing a branching vascular network terminating swelling. greatest linear dimension included all lesions, leaking network, type 2 neovascularization.During...
To identify reticular pseudodrusen (RPD) in age-related macular degeneration using multiple imaging modalities, including the blue channel image of fundus photography, infrared reflectance (IR), autofluorescence, near-infrared confocal reflectance, indocyanine green angiography, and spectral-domain optical coherence tomography (SD-OCT), to compare sensitivities specificities these modalities for detecting RPD.This study included 220 eyes from 114 patients with newly diagnosed degeneration....
Central serous chorioretinopathy (CSC) is a common disease affecting younger people and may lead to vision loss. CSC shares phenotypic overlap with age-related macular degeneration (AMD). As recent studies have revealed characteristic increase of choroidal thickness in CSC, we conducted genome-wide association study on 3,418 individuals followed by TaqMan assays 2,692 subjects, identified two susceptibility loci: CFH rs800292, an established AMD polymorphism, VIPR2 rs3793217 (P = 2.05 ×...
The use of optical coherence tomography (OCT) images is increasing in the medical treatment age-related macular degeneration (AMD), and thus, amount data requiring analysis increasing. Advances machine-learning techniques may facilitate processing large amounts image data. Among deep-learning methods, convolution neural networks (CNNs) show superior recognition ability. This study aimed to build models that could distinguish AMD from healthy OCT scans with without exudative changes using a...
To investigate the difference in intraocular vascular endothelial growth factor (VEGF) concentration between pachychoroid neovasculopathy and neovascular age-related macular degeneration (nAMD) its associations with responses to three monthly anti-VEGF injections as an initial treatment for two conditions.This study included nine eyes treatment-naïve 21 nAMD. Before intravitreal injection, aqueous humor samples were collected of VEGF was measured using enzyme-linked immunosorbent assay. The...
Purpose To evaluate the roles of known myopia-associated genetic variants for development myopic macular degeneration (MMD) in individuals with high myopia (HM), using case-control studies from Consortium Refractive Error and Myopia (CREAM). Methods A candidate gene approach tested 50 loci association HM MMD, meta-analyses comprising subjects European Asian ancestry aged 30 to 80 years 10 studies. Fifty strongest associations were chosen a previous published GWAS study. Highly (spherical...