Milly S. Tedja
A5058207757- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Optical Systems and Laser Technology
- Intraocular Surgery and Lenses
- Traditional Chinese Medicine Studies
- Surface Roughness and Optical Measurements
- Advancements in Photolithography Techniques
- Advanced optical system design
- Advanced Measurement and Metrology Techniques
- Advanced Surface Polishing Techniques
- Advanced Optical Imaging Technologies
- Integrated Circuits and Semiconductor Failure Analysis
- Optical Polarization and Ellipsometry
- Yersinia bacterium, plague, ectoparasites research
- Satellite Image Processing and Photogrammetry
- Receptor Mechanisms and Signaling
- Connexins and lens biology
- Ocular Infections and Treatments
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Cancer-related molecular mechanisms research
- Retinal and Optic Conditions
Erasmus MC
2016-2025
Erasmus University Rotterdam
2016-2023
Institute of Molecular and Clinical Ophthalmology Basel
2021-2023
UK Biobank
2021
ORCID
2021
<h3>Importance</h3> Myopia (ie, nearsightedness) is becoming the most common eye disorder to cause blindness in younger persons many parts of world. Visual impairment due myopia associated with structural changes retina and globe because elongation axis. How axial length—a sum anterior chamber depth, lens thickness, vitreous depth—and relate development visual over time unknown. <h3>Objectives</h3> To evaluate association between length, spherical equivalent, risk make projections for...
Myopia is a refractive error of the eye caused by complex interplay between nature and nurture. The aim this study was to investigate whether environmental risk factors can influence genetic effect in children developing myopia. A total 3422 participating birth-cohort Generation R underwent an extensive examination at 9 years with measurements axial length corneal radius ratio (AL/CR). Environmental were evaluated using questionnaire, scores (ERS) calculated backward regression analyses....
Purpose To evaluate the roles of known myopia-associated genetic variants for development myopic macular degeneration (MMD) in individuals with high myopia (HM), using case-control studies from Consortium Refractive Error and Myopia (CREAM). Methods A candidate gene approach tested 50 loci association HM MMD, meta-analyses comprising subjects European Asian ancestry aged 30 to 80 years 10 studies. Fifty strongest associations were chosen a previous published GWAS study. Highly (spherical...
<h3>Importance</h3> Uncertainty currently exists about whether the same genetic variants are associated with susceptibility to low myopia (LM) and high (HM) hyperopia. Addressing this question is fundamental understanding genetics of refractive error has clinical relevance for genotype-based prediction children at risk HM identification new therapeutic targets. <h3>Objective</h3> To assess a common set HM, LM, <h3>Design, Setting, Participants</h3> This association study assessed unrelated...
High myopia (HM), defined as a spherical equivalent refractive error (SER) ≤ -6.00 diopters (D), is leading cause of sight impairment, through myopic macular degeneration (MMD). We aimed to derive an improved polygenic score (PGS) for predicting children at risk HM and test if PGS predictive MMD after accounting SER.
Refractive error (RE) and myopia are complex polygenic conditions with the majority of genome-wide associated genetic variants in non-exonic regions. Given this, onset during childhood, gene-regulation is expected to play an important role its pathogenesis. This prompted us explore beyond traditional gene finding approaches. We performed a association study between non-coding RNAs enhancers, RE myopia. obtained single-nucleotide polymorphisms (SNPs) microRNA (miRNA) genes, miRNA-binding...
Purpose: To test the hypothesis that emmetropization buffers against genetic and environmental risk factors for myopia by investigating whether factor effect sizes vary depending on children's position in refractive error distribution. Methods: Refractive was assessed participants from two birth cohorts: Avon Longitudinal Study of Parents Children (ALSPAC) (noncycloplegic autorefraction) Generation R (cycloplegic autorefraction). A score calculated genotypes at 146 loci. Time spent reading,...
Purpose: To determine genetic correlations between common myopia and primary open-angle glaucoma (POAG). Methods: We tested the association of polygenic risk scores (PRSs) with POAG endophenotypes using two studies: Australian & New Zealand Registry Advanced Glaucoma (ANZRAG) study comprising 798 cases 1992 controls, Rotterdam Study (RS), a population-based 11,097 participants, in which intraocular pressure (IOP) optic disc parameter measurements were catalogued. PRSs derived from...
Neurons in the medial nucleus of trapezoid body anaesthetized rats postnatal day (P)2-6 showed burst firing with a preferred interval about 100 ms, which was stable, and second 5-30 shortened during development. In 3 out 132 cases, evidence for presence two large inputs found. vivo whole-cell recordings revealed that excitability principal neuron size its largest synaptic were developmentally matched. At P2-4, action potentials triggered by barrages small events summated to plateau...
Refractive error, measured here as mean spherical equivalent (SER), is a complex eye condition caused by both genetic and environmental factors. Individuals with strong positive or negative values of SER require spectacles other approaches for vision correction. Common risk factors have been identified genome-wide association studies (GWAS), but great part the refractive error heritability still missing. Some this may be explained rare variants (minor allele frequency [MAF] ≤ 0.01.). We...
Purpose: To study the relatively high effect of refractive error gene GJD2 in human myopia, and to assess its relationship with error, ocular biometry lifestyle various age groups. Methods: The population-based Rotterdam Study (RS), myopia case-control MYopia STudy, birth-cohort Generation R were included this study. Spherical equivalent (SER), axial length (AL), length/corneal radius (AL/CR), vitreous depth (VD), anterior chamber (ACD) measured using standard ophthalmologic procedures....