A5075239035- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Retinal Development and Disorders
- Ophthalmology and Visual Impairment Studies
- Retinal Imaging and Analysis
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Ophthalmology and Eye Disorders
- Retinal and Optic Conditions
- Tea Polyphenols and Effects
- Retinopathy of Prematurity Studies
- Connexins and lens biology
- Ocular Diseases and Behçet’s Syndrome
- Cancer-related Molecular Pathways
- Zebrafish Biomedical Research Applications
- Intraocular Surgery and Lenses
- Proteoglycans and glycosaminoglycans research
- Ocular Infections and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinoids in leukemia and cellular processes
- Advanced Glycation End Products research
- Ocular Oncology and Treatments
- Photoreceptor and optogenetics research
- Nerve injury and regeneration
Chinese University of Hong Kong
2016-2025
Hong Kong Eye Hospital
2016-2025
Shantou University
2016-2025
Prince of Wales Hospital
1998-2024
Chinese University of Hong Kong, Shenzhen
2024
Weatherford College
2023
Shantou University Medical College
2007-2021
UK Biobank
2021
Hong Kong Sanatorium and Hospital
2019
University of Georgia
2016
Age-related macular degeneration (AMD), the most common cause of irreversible vision loss in individuals aged older than 50 years, is classified as either wet (neovascular) or dry (nonneovascular). Inherited variation complement factor H gene a major risk for drusen AMD. Here we report that single-nucleotide polymorphism promoter region HTRA1, serine protease on chromosome 10q26, genetic A whole-genome association mapping strategy was applied to Chinese population, yielding P value <10(-11)....
The peak of Internet searches and social media data about the coronavirus disease 2019 (COVID-19) outbreak occurred 10–14 days earlier than daily incidences in China. had high correlation with incidences, maximum r > 0.89 all correlations. lag correlations also showed a at 8–12 for laboratory-confirmed cases 6–8 suspected cases.
To evaluate optical coherence tomography (OCT) retinal nerve fiber layer thickness (RNFLT) measurement for glaucoma progression analysis.One hundred sixteen eyes of 64 patients with who were observed within a period 5 years included. All had at least four serial RNFL measurements obtained the Stratus OCT (Carl Zeiss Meditec, Dublin, CA) and first last separated by 3 years. Visual field (VF) testing was performed on same day as imaging. Serial average RNFLTs evaluated guided analysis (GPA)....
Abstract Retinal fundus diseases can lead to irreversible visual impairment without timely diagnoses and appropriate treatments. Single disease-based deep learning algorithms had been developed for the detection of diabetic retinopathy, age-related macular degeneration, glaucoma. Here, we a platform (DLP) capable detecting multiple common referable conditions (39 classes) by using 249,620 images marked with 275,543 labels from heterogenous sources. Our DLP achieved frequency-weighted average...
Inherited retinal dystrophy (IRD) is a leading cause of blindness worldwide. Because extreme genetic heterogeneity, the etiology and genotypic spectrum IRD have not been clearly defined, there limited information on genotype-phenotype correlations. The purpose this study was to elucidate mutational correlations IRD.We developed targeted panel 164 known disease genes, 88 candidate 32 retina-abundant microRNAs, used for exome sequencing. A total 179 Chinese families with were recruited.In 99...
<h3>Importance</h3> Early onset of myopia is associated with high later in life, and irreversible once developed. <h3>Objective</h3> To evaluate the efficacy low-concentration atropine eyedrops at 0.05% 0.01% concentration for delaying myopia. <h3>Design, Setting, Participants</h3> This randomized, placebo-controlled, double-masked trial conducted Chinese University Hong Kong Eye Centre enrolled 474 nonmyopic children aged 4 through 9 years cycloplegic spherical equivalent between +1.00 D to...
This study explores the potential of Artificial Intelligence (AI) in early screening and prognosis Dry Eye Disease (DED), aiming to enhance accuracy therapeutic approaches for eye-care practitioners. Despite promising opportunities, challenges such as diverse diagnostic evidence, complex etiology, interdisciplinary knowledge integration impede interpretability, reliability, applicability AI-based DED detection methods. The research conducts a comprehensive review datasets, standards, well...
Importance Astigmatism can cause blurred vision at near and distance. It is common among schoolchildren associated with ametropia. Although the COVID-19 pandemic generated a surge in myopia prevalence children, association child astigmatism remains unknown. Objective To report of refractive corneal from 2015 to 2023 explore associations between astigmatism. Design, Setting, Participants This population-based cross-sectional study stratified all primary schools registered Education Bureau...
The endothelial (posterior) corneal dystrophies, which result from primary dysfunction, include Fuchs dystrophy (FECD), posterior polymorphous (PPCD) and congenital hereditary (CHED). Mutations in SLC4A11 gene have been recently identified patients with recessive CHED (CHED2). In this study, we show that heterozygous mutations the also cause late-onset FECD. Four [three missense (E399K, G709E T754M) one deletion mutation (c.99-100delTC)] absent ethnically matched controls were a screen of 89...
purpose. To compare macular thickness measurements obtained from time domain optical coherence tomography (OCT) and spectral OCT to evaluate their repeatability agreement. methods. Thirty-five healthy normal subjects were included. In one randomly selected eye in each subject, three serial a (Stratus OCT, Carl Zeiss Meditec, Dublin, CA) (3D OCT; Topcon, Tokyo, Japan) by an experienced technician random order. Total regional thicknesses the two OCTs compared. Their agreement was examined with...
BackgroundSpectral-domain optical coherence tomography (SDOCT) can be used to detect glaucomatous optic neuropathy, but human expertise in interpretation of SDOCT is limited. We aimed develop and validate a three-dimensional (3D) deep-learning system using volumes neuropathy.MethodsWe retrospectively collected dataset including 4877 disc cube for training (60%), testing (20%), primary validation (20%) from electronic medical research records at the Chinese University Hong Kong Eye Centre...
To monitor and measure dendritic shrinkage of retinal ganglion cells (RGCs) in a strain transgenic mice (Thy-1 YFP) that expresses yellow fluorescent proteins neurons under the control Thy-1 promoter.A total 125 RGCs from 16 eyes YFP were serially imaged with confocal scanning laser ophthalmoscope for 6 months after optic nerve crush. Quantitative analysis cell body area, axon diameter, field, number terminal branches, branch length, branching complexity, symmetry, distance disc was used to...
To determine the myopia prevalence in Hong Kong Chinese children and their parents.It was a population-based cross-sectional study. A total of 4257 aged 6-8 years, 5880 parents were recruited Children Eye Study. Cycloplegic autorefraction measured for children; non-cycloplegic parents. Parental educational level, children's outdoor time, near work collected by validated questionnaires.In 25.0% myopic, among them, 12.7% 6-year-olds, 24.4% 7-year-olds 36.1% 8-year-old. About 0.7% 8 years high...