A5031670462- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Genetic Associations and Epidemiology
- Ocular Diseases and Behçet’s Syndrome
- Cerebral Venous Sinus Thrombosis
- Drug-Induced Ocular Toxicity
- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- RNA regulation and disease
- Retinopathy of Prematurity Studies
- bioluminescence and chemiluminescence research
- Retinoids in leukemia and cellular processes
- Connexins and lens biology
- Connective tissue disorders research
- interferon and immune responses
- Mitochondrial Function and Pathology
- Cell Adhesion Molecules Research
- Advanced Glycation End Products research
- Acute Ischemic Stroke Management
- Blood Coagulation and Thrombosis Mechanisms
- Complement system in diseases
- Photochromic and Fluorescence Chemistry
- melanin and skin pigmentation
Luigi Sacco Hospital
2023
University of Iowa Stead Family Children’s Hospital
2023
University of Illinois Chicago
2012-2021
Illinois Retina Associates
2016-2021
University of Arkansas for Medical Sciences
2021
Diagnostics Research Group
2020
Arkana Laboratories
2020
California Retina Consultants
2015-2016
University of Illinois Urbana-Champaign
2014
University of Chicago
2006-2012
<h3>Aims:</h3> The aim of this study was to determine the impact diabetic macular oedema (DME) on quality life (QOL) in patients with type 2 diabetes mellitus. <h3>Methods:</h3> a prospective, consecutive, non-comparative case series. An observational evaluated vision and vision-specific QOL using 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25). Mean VFQ-25 subscale scores were compared mean score groups 1 retinopathy (T1DR) varying degrees age-related degeneration...
Abstract Purpose Diabetic retinopathy is the most common eye complication in patients with diabetes. The purpose of this study to identify genetic factors contributing severe diabetic retinopathy. Methods A genome‐wide association approach was applied. In Genetics Diabetes Audit and Research Tayside Scotland (Go DARTS ) datasets, cases were defined as type 2 who ever graded having background (Level R3) or proliferative R4) at least one according Scottish Retinopathy Grading Scheme once...
Age-related macular degeneration (AMD) is the most common cause of irreversible visual loss in developed world. Previous studies have demonstrated that c.1204T>C, p.Tyr402His allelic variant complement factor H (CFH) gene associated with an approximately three-fold increased risk for AMD Caucasians predominantly European descent. Both prevalence as well phenotypic spectrum varies widely among persons different ethnicities. We hypothesized populations a lower might also CFH allele. In this...
To elucidate the phenotypic and biochemical characteristics of a novel mutation associated with autosomal dominant cone-rod dystrophy (adCORD).Twenty-three family members CORD pedigree underwent clinical examinations, including visual acuity tests, standardized full-field ERG, fundus photography. Genomic DNA was screened for mutations in GCAP1 exons using sequencing single-strand conformational polymorphism (SSCP) analysis. Function stability recombinant GCAP1-L151F were tested as function...
With Ranibizumab and Antiparasitic TherapyChoroidal neovascular membranes (CNVMs) rarely complicate toxoplasmic chorioretinitis [1][2][3][4][5] are managed by observation; antiparasitic, anti-inflammatory medication; laser photocoagulation; surgical excision; or photodynamic therapy, with variable outcomes.As occurs CNVMs secondary to age-related macular degeneration, Toxoplasma gondii increases expression of hypoxia-inducible factor-1␣ in tissue cultures along vascular endothelial growth...
The purpose of this study is to attempt replicate the top single nucleotide polymorphism (SNP) associations from a previous genome-wide association (GWAS) for sight-threatening complications diabetic retinopathy in an independent cohort subjects Wisconsin Epidemiologic Study Diabetic Retinopathy (WESDR).
To determine the histidine frequency in patients with cuticular drusen phenotype of age-related macular degeneration (AMD).Fifty individuals were identified who met criteria for using a standard threshold photograph. We genotyped DNA samples polymerase chain reaction-based restriction digest assay. Seven hundred typical AMD and 252 controls also genotyped. Fisher exact test was used to analyze significance allele differences.The variant present 70% (frequency +/- SE, 0.70 0.05) cohort, 55%...
We investigated the function of Fas in photoreceptors.Postmortem human eyes and mouse-derived photoreceptor cells (661W) were examined for expression by situ hybridization immunofluorescence. 661W treated with FasL or agonistic antibody, exposed to light with/without pharmacological manipulation signaling, followed apoptosis detection TUNEL, immunofluorescence fluorescence activated cell scanning (FACS). Fractionated cellular extracts used detect protein phosphorylation after...
Degenerative loss of photoreceptors occurs in inherited and age-related retinal degenerative diseases. A chemical screen facilitates development new testing routes for neuroprotection mechanistic investigation. Herein, we conducted a mouse-derived photoreceptor (661W cell)-based high throughput the Food Drug Administration-approved Prestwick drug library to identify putative cytoprotective compounds against light-induced, synthetic visual chromophore-precipitated cell death. Different...
To identify the genetic factors associated with familial non-arteritic anterior ischemic optic neuropathy (NA-AION) in a large pedigree.Eleven family members of single pedigree, including six affected NA-AION, underwent detailed clinical examinations. The mitochondrial DNA proband was sequenced its entirety search disease-causing mutations NA-AION pedigree. A control panel comprising 1488 patients suspected having Leber hereditary (LHON) and 97 general-population subjects screened for...
The use of text mining and natural language processing can extend into the realm knowledge acquisition management for biomedical applications. In this paper, we describe how implemented techniques on transcribed verbal descriptions from retinal experts disease features. feature-attribute pairs generated were then incorporated within a user interface collaborative ontology development tool. This tool, IDOCS, is being used in domain to help specialists reach consensus common describing...