A5070078751- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Acute Myeloid Leukemia Research
- Biosensors and Analytical Detection
- Nanocluster Synthesis and Applications
- Histone Deacetylase Inhibitors Research
- Advanced Nanomaterials in Catalysis
- Electrochemical sensors and biosensors
- Fungal Plant Pathogen Control
- Advanced Biosensing Techniques and Applications
- Plant Disease Resistance and Genetics
- Acute Lymphoblastic Leukemia research
- Ophthalmology and Eye Disorders
- Microtubule and mitosis dynamics
- Nanoplatforms for cancer theranostics
- Evaluation Methods in Various Fields
- MicroRNA in disease regulation
- Carbon and Quantum Dots Applications
- Biochemical Analysis and Sensing Techniques
- Epigenetics and DNA Methylation
- T-cell and Retrovirus Studies
- melanin and skin pigmentation
- Connexins and lens biology
- Advanced Surface Polishing Techniques
Zhejiang University
2014-2025
Suzhou University of Science and Technology
2023-2024
Zhejiang University of Technology
2022-2024
Chinese Academy of Sciences
2010-2023
Shanghai Jiao Tong University
2018-2023
University of Cambridge
2023
University of Shanghai for Science and Technology
2022-2023
Institute of Botany
2022-2023
China National Botanical Garden
2022
Queen's University
2022
Engineered nanoparticles have provided a basis for innovative agricultural applications, specifically in plant disease management. In this interdisciplinary study, by conducting comparison studies using macroscale magnesium oxide (mMgO), we evaluated the fungicidal activity of MgO (nMgO) against soilborne Phytophthora nicotianae and Thielaviopsis basicola first time under laboratory greenhouse conditions. vitro revealed that nMgO could inhibit fungal growth spore germination impede...
Medicine's ability to quickly respond challenges raises questions from researchers, practitioners, and society as a whole. Our task in this study was identify key atypical current factors influencing the development of medicine predict short, medium, long term. To implement our study, we selected 22 medical experts applied three-level Delphi method. The trends caused by COVID-19 have short-term impact, but they will launch other drivers that transform healthcare industry. Well-being...
The titanium alloy artificial knee joint is used extensively in the current medical industry due to its distinct characteristics and properties that are like real human joint, but it does need be polished improve performance service life before can used. Due complicated surface profile, traditional abrasive flow machining technique cannot achieve a good finish offering uniformity quality. Thus, this paper, proper constrained channel designed conduct of overcome these issues. A numerical...
Exploring accurate, noninvasive, and inexpensive disease diagnostic sensors is a critical task in the fields of chemistry, biology, medicine. The complexity biological systems explosive growth biomarker data have driven machine learning to become powerful tool for mining processing big from diagnosis sensors. With development bioinformatics artificial intelligence (AI), models formed by been able guide more sensitive accurate molecular computing. This review presents an overview collection...
It is demonstrated that miRNAs exhibit significant regulatory roles in a series of biological processes and associated with diverse human diseases. Herein, we report convenient fluorescent biosensor for the quantitative determination miR-21, key miRNA related to cardio-cerebrovascular Our proposal involves not only rational design single stranded DNA as probe, successively including C-rich sequence synthetic template DNA/Ag nanoclusters (DNA/AgNCs), complementary (Com) hybridize G-rich form...
An enzyme cascade-triggered reaction with novel signal generation mechanism is beneficial for the development and insight of cascade, which extensively used transduction in potential applications. Inspired by fluorogenic chromogenic between dopamine resorcinol, specific catalytic properties alkaline phosphatase (ALP) tyrosinase, we designed synthesized an unconventional substrate ALP, named p-aminoethyl-phenyl phosphate disodium salt (PAPP). As expected, ALP tyrosinase-incubated PAPP...
A versatile and ultrasensitive colorimetric detection platform has been developed based on the hybridization chain reaction (HCR)-triggered enzyme cascade amplification in this work. The proposal involves preparation of two different hairpin DNA strands consisting H1, modified with glucose oxidase (GOx-H1) H2, horseradish peroxidase (HRP-H2). H1 H2 were composed complementary sequence nucleic acid target (T) interlaced stem-loop sequences. In detection, T its induces autonomous assembly...
Alkaline phosphatase (ALP) usually acts as a signal transmitter in enzyme-linked immunosorbent assay (ELISA); therefore, developing an attractive ALP activity assay, especially using preferable substrate, would help improve the efficiency and convenience of ELISA practical applications. Herein we have first prepared original creative named m-hydroxyphenyl phosphate sodium salt (m-HPP), with desirable dephosphorylation site for ALP. On basis ALP-catalyzed hydrolysis m-HPP to resorcinol its...
As a well-known copper-containing oxidase, tyrosinase has been anticipated to serve as the biomarker of skin diseases. We describe here an exquisite label-free fluorescent and colorimetric dual-readout assay its activity, inspired by specific oxidation ability monophenolamine substrates catecholamines unique fluorogenic reaction between resorcinol catecholamines. By employing commercially available tyramine model substrate (dopamine product), it is found that tyrosinase-incubated solution...
Prorocentrum donghaiense blooms occur frequently in the Yangtze River estuary and adjacent East China Sea. These have damaged marine ecosystems caused enormous economic losses over past 2 decades. Thus, highly efficient, low-cost, ecofriendly approaches must be developed to control P. blooms. In this study, a bacterial strain (strain Y42) was identified as Paracoccus sp. used lyse The supernatant of Y42 culture able donghaiense, algicidal activity stable with different temperatures durations...
MicroRNAs (miRNAs) play vital roles in biological activities, but their vivo imaging is still challenging due to the low abundance and lack of efficient fluorescent tools. RNA aptamers with high affinity background emerge for bioimaging yet suffering from brightness. We introduce a rational design based on target-mediated entropy-driven toehold exchange (EDTE) induce release aptamer subsequently light up corresponding fluorophore, which achieves selective miRNAs good stability both living...
Being a typical copper-containing oxidase, tyrosinase plays critical roles in biological activity, and its aberrant expression might cause diverse skin diseases. Herein, we, for the first time, have found an interesting green fluorogenic reaction between methyldopa ethanolamine. By combining transmission electron microscopy, UV–vis absorption spectroscopy, Fourier transform infrared X-ray photoelectron MALDI-TOF mass spectrum analysis, we confirmed that there is reliable method preparing...
A concept for a pure DNA hydrogel has been demonstrated in which triplex structures act as the core components and are assisted by single strands artfully designed Y-shaped structures. Typically, structure is based on protonated cytosine-guanine-cytosine (C-G·C+) formed at pH 5.0 disassembles 7.0, whereas thymine-adenine-thymine (T-A·T)-based 7.0 10.0. Therefore, such structure-based hydrogels provide pH-controlled reversible self-assembly of with transition between gel liquid states. More...
Aqueous-phase synthesis of the Eu(DPA)<sub>3</sub>@Lap nanohybrid and its application in luminescence recognition Cu<sup>2+</sup>, PPi, ALP.
G-quadruplex has been developed as an innovator for analytical chemistry and biomedicine due to its vibrant binding activity, structural polymorphism, critical roles in biological regulation. Herein, a simple but versatile platform was obtained by integrating split fluorophore into molecular beacon, where the photoinduced electron transfer could occur when approached preformed G-quadruplex/hemin complexes. Such design subtly combined G4 disruption-induced fluorescent turn-on strategy...