Eranga N. Vithana
A5085332370- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- Corneal Surgery and Treatments
- Ophthalmology and Visual Impairment Studies
- Ophthalmology and Eye Disorders
- Genetic Associations and Epidemiology
- RNA regulation and disease
- Retinopathy of Prematurity Studies
- Connexins and lens biology
- Connective tissue disorders research
- Retinoids in leukemia and cellular processes
- Intraocular Surgery and Lenses
- Cellular transport and secretion
- Ion Transport and Channel Regulation
- melanin and skin pigmentation
- Retinal and Optic Conditions
- Ubiquitin and proteasome pathways
- Biomedical Research and Pathophysiology
- Ocular Diseases and Behçet’s Syndrome
- Ocular Disorders and Treatments
- Cerebral Venous Sinus Thrombosis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Singapore Eye Research Institute
2016-2025
Duke-NUS Medical School
2014-2025
Singapore National Eye Center
2014-2023
National University of Singapore
2011-2020
Singapore General Hospital
2020
National University Health System
2012-2017
Yong In University
2012-2015
St Thomas' Hospital
2014
King's College London
2014
Genomics (United Kingdom)
2011-2012
Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However, its molecular and cellular causes are not well understood. Elevated intraocular pressure (IOP) major risk factor, but many patients have normal IOP. Colocalization Mendelian randomization analysis >240 POAG IOP genome-wide association study (GWAS) loci overlapping expression splicing quantitative trait (e/sQTLs) in 49 GTEx tissues retina...
The endothelial (posterior) corneal dystrophies, which result from primary dysfunction, include Fuchs dystrophy (FECD), posterior polymorphous (PPCD) and congenital hereditary (CHED). Mutations in SLC4A11 gene have been recently identified patients with recessive CHED (CHED2). In this study, we show that heterozygous mutations the also cause late-onset FECD. Four [three missense (E399K, G709E T754M) one deletion mutation (c.99-100delTC)] absent ethnically matched controls were a screen of 89...
Retinitis pigmentosa (RP), the commonest form of inherited retinal dystrophies is a clinically and genetically heterogeneous disorder. It characterized by progressive degeneration peripheral retina leading to night blindness loss visual field. RP either in an autosomal dominant, recessive or X-linked mode. A locus (RP18) for dominant was previously mapped linkage analysis two large pedigrees chromosome 1p13–q21. The human HPRP3 gene, orthologue yeast pre-mRNA splicing factor (PRP3),...
Abstract Age-related macular degeneration (AMD) is a major cause of blindness, but presents differently in Europeans and Asians. Here, we perform genome-wide exome-wide association study on 2,119 patients with exudative AMD 5,691 controls, independent replication 4,226 10,289 all East Asian descent, as part The Genetics Asians (GAMA) Consortium. We find strong between CETP Asp442Gly (rs2303790), an Asian-specific mutation, increased risk (odds ratio (OR)=1.70, P =5.60 × 10 −22 ). allele...
Primary open-angle glaucoma (POAG) is the leading cause of irreversible blindness worldwide for which 15 disease-associated loci had been discovered. Among them, only 5 have associated with POAG in Asians. We carried out a genome-wide association study and replication that included total 7378 cases 36 385 controls from Japanese population. After combining two sets, we identified 11 POAG-associated loci, including 4 known (CDKN2B-AS1, ABCA1, SIX6 AFAP1) 7 novel (FNDC3B, ANKRD55-MAP3K1, LMX1B,...
Genome-wide association studies (GWAS) on Parkinson's disease (PD) have mostly been done in Europeans and Japanese. No study has Han Chinese, which make up nearly a fifth of the world population. We conducted first Chinese GWAS analysing total 22,729 subjects (5,125 PD cases 17,604 controls) from Singapore, Hong Kong, Malaysia, Korea, mainland China Taiwan. performed imputation, merging logistic regression analyses 2,402,394 SNPs passing quality control filters 779 cases, 13,227 controls,...