A5053263917- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Ophthalmology and Eye Disorders
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Neurological Disorders and Treatments
- Cerebral Venous Sinus Thrombosis
- Proteoglycans and glycosaminoglycans research
- Ocular Surface and Contact Lens
- Immune Response and Inflammation
- Amino Acid Enzymes and Metabolism
- Advanced Glycation End Products research
- Folate and B Vitamins Research
- NF-κB Signaling Pathways
- melanin and skin pigmentation
- Corneal Surgery and Treatments
- Optical Coherence Tomography Applications
- Cerebrovascular and genetic disorders
- Nerve injury and regeneration
- Fibroblast Growth Factor Research
- Ophthalmology and Visual Health Research
- Microbial metabolism and enzyme function
University of Yamanashi
2014-2024
Kyoto Prefectural University of Medicine
2024
University of Yamanashi Hospital
2006-2022
Ophthalmology Associates (United States)
2017
Japan Society for the Promotion of Science
2016
Yokohama City University
2009
Tama University
2006
University of California, San Diego
2002-2004
Glaucoma Research Foundation
2003-2004
Hara Eye Hospital
2000
Purpose To assess anxiety and depression in patients with primary open-angle glaucoma (POAG). Design Multicenter prospective case-control study. Participants Two hundred thirty POAG 230 sex-matched age-matched reference subjects no chronic ocular conditions except cataracts. Intervention Anxiety were evaluated using Hospital Depression Scale (HADS) questionnaire, which consists of 2 subscales ranges 0 to 21, representing (HADS-A) (HADS-D). Main Outcome Measure The prevalence (a score more...
Primary open-angle glaucoma (POAG) is the leading cause of irreversible blindness worldwide for which 15 disease-associated loci had been discovered. Among them, only 5 have associated with POAG in Asians. We carried out a genome-wide association study and replication that included total 7378 cases 36 385 controls from Japanese population. After combining two sets, we identified 11 POAG-associated loci, including 4 known (CDKN2B-AS1, ABCA1, SIX6 AFAP1) 7 novel (FNDC3B, ANKRD55-MAP3K1, LMX1B,...
purpose. Toll-like receptor 4 (TLR4) is a transmembrane that mediates immune responses to exogenous and endogenous ligands interacts with heat shock proteins, which are reportedly involved in normal tension glaucoma (NTG). This study was undertaken investigate whether TLR4 polymorphisms associated NTG. methods. Two hundred fifty Japanese patients NTG 318 healthy control subjects were recruited. Eight single-nucleotide (SNPs) the gene genotyped, allelic phenotypic diversity assessed between...
To assess the risk factors for anxiety and depression in patients with glaucoma.Anxiety 408 glaucoma were evaluated using hospital scale (HADS) questionnaire, which consists of two subscales, representing HADS-anxiety (HADS-A) HADS-depression (HADS-D). identify depression, stepwise multiple linear regression analyses carried out HADS-A HADS-D subscores as dependent variables demographic clinical features independent variables.A analysis revealed significantly related to be age (β=-0.046,...
<b><i>Purpose:</i></b> To investigate the possible roles of various cytokines or growth factors in pathogenesis exudative age-related macular degeneration (AMD) by comparing aqueous humor levels 14 between eyes with polypoidal choroidal vasculopathy (PCV) and those neovascular AMD. <b><i>Methods:</i></b> Forty from 40 patients treatment-naïve AMD consisting 18 22 PCV were studied. Twenty 20 no retinal pathology who underwent cataract surgery...
Although intraocular pressure (IOP) is the most definitive cause of glaucoma, a subtype open angle glaucoma (OAG) termed normal tension (NTG), which occurs in spite IOP, accounts for large part cases, especially Japan. To find common genetic variants contributing to NTG Japanese patients, we conducted genome-wide association study (GWAS). We performed first screening 531,009 autosomal SNPs with discovery cohort 286 cases and 557 controls, then second top 30 suggestive loci an independent 183...
purpose. To evaluate optic nerve damage in mice after laser-induced ocular hypertension. methods. Ocular hypertension was induced unilaterally 13 NIH Black Swiss by laser photocoagulation of the limbus. Over following 12 weeks, intraocular pressure (IOP) measured at regular intervals microneedle method. The nerves these and seven normal untreated were then processed conventionally for electron microscopy, cross sections 300 μm posterior to globe collected. Low- high-magnification images...
Transgenic (Col1a1(r/r)) mice gradually develop elevated intraocular pressure (IOP) with open angles. The present study was undertaken to evaluate optic nerve axonal loss time in these mice.The IOP of transgenic and control wild-type (Col1a1(+/+)) measured at 7, 12, 16, 24, 36, 54 weeks age using a microneedle method. Col1a1(r/r) Col1a1(+/+) 24 were randomly selected their nerves processed conventionally for electron microscopy. Optic cross-sections collected 300 micro m posterior the globe....
In Brief Purpose: To investigate genetic factors associated with choroidal vascular hyperpermeability (CVH) and subfoveal thickness in eyes treatment-naive polypoidal vasculopathy. Methods: We studied 149 consecutive patients The presence of CVH was evaluated using indocyanine green angiography. Subfoveal axial length were measured by spectral domain optical coherence tomography biometry, respectively. Genotyping three single nubleotide polymorphisms (SNPs), including age-related maculopathy...
To report the 5-year incidence of visual impairment after mitomycin C-augmented trabeculectomy (MMC trabeculectomy) and risk factors for impairment.This is a multicentre prospective observational cohort study. Among glaucoma patients registered in Collaborative Bleb-related Infection Incidence Treatment Study performed Japan, with eyes meeting following qualifications were included: primary open-angle glaucoma; angle-closure exfoliative ≥3/60 blindness analysis; ≥20/60 low-vision analysis...
Normal-tension glaucoma (NTG) is a heterogeneous disease characterized by retinal ganglion cell (RGC) death leading to cupping of the optic nerve head and visual field loss at normal intraocular pressure (IOP). The pathogenesis NTG remains unclear. Here, we describe single nucleotide mutation in exon 2 methyltransferase-like 23 (METTL23) gene identified 3 generations Japanese family with NTG. This caused METTL23 mRNA aberrant splicing, which abolished protein production altered subcellular...
To assess the relationship between regional variation of axon loss and optic nerve head anatomy in laser-induced experimental glaucoma mouse.Experimental was induced unilaterally eight NIH Swiss black mice. Intraocular pressure (IOP) measured for 12 weeks, mice were killed. The eyes enucleated, both nerves dissected processed conventionally electron microscopy. Low- high-magnification images cross sections 300 microm posterior to globe collected systematically masked before analysis. For...
The S1 RNA binding domain 1 (SRBD1) and elongation of long-chain fatty acids family member 5 (ELOVL5) have been reported to be susceptibility genes for early-onset normal-tension glaucoma (NTG). present study we conducted assess whether these were associated with primary open-angle (POAG), including late-onset NTG high-tension (HTG).Three hundred seventy Japanese patients POAG, 158 212 HTG 191 control subjects analyzed SRBD1 (rs3213787) ELOVL5 (rs735860) gene polymorphisms.The A allele...
Objective To investigate the prevalence and genetic characteristics of geographic atrophy (GA) among elderly Japanese with advanced age-related macular degeneration (AMD) in a clinic-based study. Methods Two-hundred ninety consecutive patients AMD were classified into typical neovascular AMD, polypoidal choroidal vasculopathy (PCV), retinal angiomatous proliferation (RAP) or (GA). Genetic variants ARMS2 A69S (rs10490924) CFH I62V (rs800292) genotyped using TaqMan Genotyping Assays. The...
To investigate whether the LOC387715/ARMS2 variants are associated with an angiographic phenotype, including lesion size and composition, in subfoveal polypoidal choroidal vasculopathy.Ninety-two subjects symptomatic vasculopathy, whose visual acuity was from 0.1 to 0.5 on Landolt chart, were genotyped for LOC387715 polymorphism (rs10490924) using denaturing high-performance chromatography. The composition size, evaluated by evaluators who masked genotype. Lesion assessed greatest linear...
To investigate whether there is an association of the LOC387715 A69S genotype with visual prognosis after photodynamic therapy in eyes polypoidal choroidal vasculopathy (PCV).Photodynamic was repeated every 3 months until disappearance angiographic signs active lesions 71 patients PCV who were followed-up for at least 12 months. All genotyped polymorphism (rs10490924, risk-allele T).Although no statistically significant difference mean baseline acuity (P = 0.53) among genotypes, a both...
Purpose To test the genetic association between Japanese patients with primary open-angle glaucoma (POAG) and previously reported POAG susceptibility loci to perform genotype–phenotype analysis. Methods Genetic associations for 27 SNPs from 16 linked were assessed using genome-wide SNP data of cohort (565 1,104 controls). Reproducibility assessment was tested in 607 cases 455 controls (second cohort) a targeted genotyping approach. For POAG-associated variants, correlation study (additive,...