A5026360034- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Geology and Paleoclimatology Research
- Retinal Development and Disorders
- Ophthalmology and Eye Disorders
- Ocular Surface and Contact Lens
- Neurological Disorders and Treatments
- Ophthalmology and Visual Impairment Studies
- Paleontology and Stratigraphy of Fossils
- Retinal and Optic Conditions
- Ocular Diseases and Behçet’s Syndrome
- Geological formations and processes
- Geological and Geochemical Analysis
- Neuroscience and Neuropharmacology Research
- Retinal and Macular Surgery
- Intraocular Surgery and Lenses
- Nitric Oxide and Endothelin Effects
- Protease and Inhibitor Mechanisms
- Isotope Analysis in Ecology
- Visual perception and processing mechanisms
- Receptor Mechanisms and Signaling
- Amino Acid Enzymes and Metabolism
- Adenosine and Purinergic Signaling
University of Yamanashi
2016-2025
University of Yamanashi Hospital
2005-2025
Tokyo University of Agriculture and Technology
2025
University of Toyama
2012-2024
Josai University
2024
Kyoto Prefectural University of Medicine
2024
Natural History Museum and Institute
2024
Sekisui Chemical (Japan)
2022
Weatherford College
2021
Wakayama Medical University
2019
Purpose To assess anxiety and depression in patients with primary open-angle glaucoma (POAG). Design Multicenter prospective case-control study. Participants Two hundred thirty POAG 230 sex-matched age-matched reference subjects no chronic ocular conditions except cataracts. Intervention Anxiety were evaluated using Hospital Depression Scale (HADS) questionnaire, which consists of 2 subscales ranges 0 to 21, representing (HADS-A) (HADS-D). Main Outcome Measure The prevalence (a score more...
Primary open-angle glaucoma (POAG) is the leading cause of irreversible blindness worldwide for which 15 disease-associated loci had been discovered. Among them, only 5 have associated with POAG in Asians. We carried out a genome-wide association study and replication that included total 7378 cases 36 385 controls from Japanese population. After combining two sets, we identified 11 POAG-associated loci, including 4 known (CDKN2B-AS1, ABCA1, SIX6 AFAP1) 7 novel (FNDC3B, ANKRD55-MAP3K1, LMX1B,...
To investigate systemic and ocular risk factors for angle closure (AC) in older Singaporeans to determine if these are different men vs women Chinese non-Chinese persons.A cross-sectional study of 2042 subjects with phakia 50 years or recruited from a primary care clinic Singapore. Subjects completed detailed questionnaire underwent refraction, biometry, gonioscopy. Univariate multivariate analyses were performed AC.The prevalence AC among this population was 19.3% (n = 395); 89.4% 1826) the...
To develop an artificial intelligence (AI) algorithm that diagnoses cataracts/corneal diseases from multiple conditions using smartphone images.
The mechanism by which prostaglandin(PG)F2 alpha increases uveoscleral outflow and lowers intraocular pressure in primates is not known. In cultured human ciliary muscle cells, PGF2 induces the expression of protooncogene c-fos known to induce transcription genes such as matrix metalloproteinase-1 (MMP-1) MMP-3 other cell systems. As these enzymes are initially secreted proenzymes, present study was undertaken determine if PG treatment cells secrete either proMMP-1 or proMMP-3.Human smooth...
purpose. Toll-like receptor 4 (TLR4) is a transmembrane that mediates immune responses to exogenous and endogenous ligands interacts with heat shock proteins, which are reportedly involved in normal tension glaucoma (NTG). This study was undertaken investigate whether TLR4 polymorphisms associated NTG. methods. Two hundred fifty Japanese patients NTG 318 healthy control subjects were recruited. Eight single-nucleotide (SNPs) the gene genotyped, allelic phenotypic diversity assessed between...
To assess the risk factors for anxiety and depression in patients with glaucoma.Anxiety 408 glaucoma were evaluated using hospital scale (HADS) questionnaire, which consists of two subscales, representing HADS-anxiety (HADS-A) HADS-depression (HADS-D). identify depression, stepwise multiple linear regression analyses carried out HADS-A HADS-D subscores as dependent variables demographic clinical features independent variables.A analysis revealed significantly related to be age (β=-0.046,...
Abstract Excitotoxicity is well known in the neuronal death brain and also linked to damages retina. Recent accumulating evidence show that microglia greatly affect excitotoxicity brain, but their roles retina have received only limited attention. Here, we report retinal mediated by microglia. To this end, employed three discrete methods, is, pharmacological inhibition of minocycline, ablation an antagonist for colony stimulating factor 1 receptor (PLX5622), genetic using Iba1 ‐tTA:: DTA...
To develop a large-scale real clinical database of glaucoma (Japanese Archive Multicentral Databases in Glaucoma: JAMDIG) and to investigate the effect treatment.The study included total 1348 eyes 805 primary open-angle patients with 10 visual fields (VFs) measured 24-2 or 30-2 Humphrey Field Analyzer (HFA) intraocular pressure (IOP) records institutes Japan. Those reliable VFs were further identified (638 417 patients). Mean deviation (mTD) 52 test points HFA VF was calculated, relationship...
Abstract Rationale: Coronavirus disease 2019 (COVID-19) has spread worldwide. It involves multiple organs of infected individuals and encompasses diverse clinical manifestations. We report a case acute optic neuritis (ON) associated with myelin oligodendrocyte glycoprotein (MOG) antibody possibly induced by COVID-19. Patient concerns: A 47-year-old man presented to our clinic left eye pain vision loss. Magnetic resonance imaging the orbit revealed bilateral high intensity nerve sheaths. He...
We compared the short-term outcomes between 3-monthly aflibercept and brolucizumab injections for treatment-naïve polypoidal choroidal vasculopathy (PCV). A total of 52 eyes were included. Patients received 3 monthly intravitreal (n = 38) or 14). Indocyanine green angiography (ICGA) was performed at baseline 3-month visit. Selection anti-VEGF agents depended on time. In brolucizumab-treated group, best-corrected visual acuity (BCVA) improved from 0.27 ± 0.34 (log MAR unit) to 0.20 0.24...
We studied the effects of transforming growth factor-β 1 (TGF-β 1) on genetic expression procollagen type I and III its structural properties in early stages healing rat Achilles tendon. The tendons 90 rats were transsected repaired immediately. TGF-β dissolved phosphate-buffered saline was injected locally at repair site using two different doses, outcomes both groups compared to that control group given only. Five animals each killed one, two, four weeks postoperatively, tendon evaluated....
Although intraocular pressure (IOP) is the most definitive cause of glaucoma, a subtype open angle glaucoma (OAG) termed normal tension (NTG), which occurs in spite IOP, accounts for large part cases, especially Japan. To find common genetic variants contributing to NTG Japanese patients, we conducted genome-wide association study (GWAS). We performed first screening 531,009 autosomal SNPs with discovery cohort 286 cases and 557 controls, then second top 30 suggestive loci an independent 183...
Purpose To compare matrix metalloproteinase (MMP) activities in human vitreous samples from patients with diabetic retinopathy (DR) and other vitreoretinal diseases, to investigate the factors influencing MMP DR samples. Methods Thirty-one 17 nondiabetic (from nine macular holes eight epiretinal membranes) were examined. Samples collected at time of pars plana vitrectomy subjected substrate zymography conduct a quantitative analysis activity. Immunoblotting against antihuman MMP-1, 2, 9 was...
The physiological function of the polyamine-induced protein (PI protein), whose synthesis is stimulated at an early stage after addition putrescine to growing cells a polyamine-requiring mutant Escherichia coli (Mitsui, K., Igarashi, Kakegawa, T., and Hirose, S. (1984) Biochemistry 23, 2679-2683), has been studied. following findings clearly show that PI binding oligopeptide transport system. (a) was found in periplasmic fraction. (b) When restriction map clone for gene compared with...
To compare anterior chamber depth measurements by three non-contact devices-the IOLMaster, scanning peripheral analyser (SPAC), and Visante segment optical coherence tomography (AS-OCT) METHODS: Prospective, cross sectional study of 497 phakic subjects over 50 years age attending a community clinic in Singapore. Anterior the right eye was measured using all techniques same investigator. Depth were made from corneal epithelium to lens surface. The values obtained compared Bland-Altman...