A5103123579- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Intraocular Surgery and Lenses
- Retinal Development and Disorders
- Ophthalmology and Eye Disorders
- Retinal Imaging and Analysis
- Corneal Surgery and Treatments
- Ophthalmology and Visual Impairment Studies
- Retinal and Macular Surgery
- Neurological Disorders and Treatments
- Ocular Disorders and Treatments
- Ocular Oncology and Treatments
- Ocular Surface and Contact Lens
- Retinal and Optic Conditions
- Ocular Infections and Treatments
- Cerebral Venous Sinus Thrombosis
- Nerve injury and regeneration
- Connexins and lens biology
- Older Adults Driving Studies
- Proteoglycans and glycosaminoglycans research
- Retinopathy of Prematurity Studies
- Ocular Diseases and Behçet’s Syndrome
- Traffic and Road Safety
- Gaze Tracking and Assistive Technology
Niigata University
2016-2025
Niigata University Medical and Dental Hospital
2011-2024
Minamiaoyama Eye Clinic
2016
Yamamoto Hospital
2013
Yoshino Kogyosho (Japan)
2013
May Institute
2013
American Academy of Ophthalmology
2013
Keio University
2012
Yokohama City University
2009
Retina Associates
2002
Although neurotrophins have been assessed as candidate therapeutic agents for neural complications of diabetes, their involvement in diabetic retinopathy has not fully characterized. We found that the protein and mRNA levels brain-derived neurotrophic factor (BDNF) streptozotocin-induced rat retinas were reduced to 49% (P < 0.005) 74% 0.05), respectively, those normal control animals. In addition, dopaminergic amacrine cells appeared be degenerating retinas, revealed by tyrosine...
To investigate the concentration of tumor necrosis factor (TNF)-alpha in aqueous humor patients with glaucoma, including correlations glaucoma subtypes and intraocular pressure.The study population comprised 84 open-angle who were scheduled for filtration or cataract surgery. Glaucoma subgroups included 29 cases primary (POAG), 28 normal-tension (NTG), 27 exfoliation (ExG). Seventy-nine senile recruited as control subjects. The concentrations TNF-alpha measured an enzyme-linked immunosorbent...
purpose. Toll-like receptor 4 (TLR4) is a transmembrane that mediates immune responses to exogenous and endogenous ligands interacts with heat shock proteins, which are reportedly involved in normal tension glaucoma (NTG). This study was undertaken investigate whether TLR4 polymorphisms associated NTG. methods. Two hundred fifty Japanese patients NTG 318 healthy control subjects were recruited. Eight single-nucleotide (SNPs) the gene genotyped, allelic phenotypic diversity assessed between...
Neuromyelitis optica spectrum disorder (NMOsd) is an autoimmune of the central nervous system characterized by aquaporin-4 (AQP4) autoantibodies. The aim this study was to elucidate characteristics involvement anterior visual pathway (AVP) and neurodegeneration via glia-neuron interaction in NMOsd.Thirty Japanese patients with serologically verified NMOsd were assessed a neuro-ophthalmological study. Using 27 tissue blocks from 13 other cases NMOsd, we performed neuropathological analysis...
This study sought to elucidate changes in the levels and distribution of brain-derived neurotrophic factor (BDNF) retina throughout aging depending on visual experience.Protein mRNA BDNF were quantified by enzyme-linked immunosorbent assay (ELISA) semiquantitative reverse transcription-polymerase chain reaction (RT-PCR), respectively. Levels assayed retinas rats postnatal day (P)2, P7, P14 (approximate time eye opening) at 1 month (M), 3M, 8M, 18M age. Changes expression localization...
To investigate sequence variations in the optineurin (OPTN) gene and their association with TNF-alpha polymorphisms Japanese patients glaucoma.The OPTN was analyzed blood samples from 629 subjects. There were 194 primary open-angle glaucoma (POAG), 217 normal-tension (NTG), 218 no eye disease (control subjects). The screened for mutations by denaturing high-performance liquid chromatography. Genotyping of three -308G-->A, -857C-->T, -863C-->A promoter region performed. associations between...
To investigate the significance of vision-specific quality life (QOL) in glaucoma patients based on location visual field defects.We examined 336 eyes 168 patients. The 25-item National Eye Institute Visual Function Questionnaire was used to evaluate patients' QOL. testing performed using Humphrey Field Analyzer; divided into 10 clusters. We defined eye with better mean deviation as and fellow worse eye. A single linear regression analysis applied assess relationship between QOL clustered...
Abstract Mitophagy plays an important role in the maintenance of mitochondrial homeostasis. PTEN-induced kinase (PINK1), a key regulator mitophagy, is degraded constitutively under steady-state conditions. During it becomes stabilized outer membrane, particularly stress conditions, such as treatment with uncouplers, generation excessive reactive oxygen species, and formation protein aggregates mitochondria. Stabilized PINK1 recruits activates E3 ligases, Parkin ubiquitin ligase (MUL1), to...
Inherited retinal diseases (IRDs) comprise a phenotypically and genetically heterogeneous group of ocular disorders that cause visual loss via progressive degeneration. Here, we report the genetic characterization 1210 IRD pedigrees enrolled through Japan Eye Genetic Consortium analyzed by whole exome sequencing. The most common phenotype was retinitis pigmentosa (RP, 43%), followed macular dystrophy/cone- or cone-rod dystrophy (MD/CORD, 13%). In total, 67 causal genes were identified in 37%...
We examined the relationship between contrast sensitivity (CS) and visual field stage/severity in patients with open-angle glaucoma (OAG), correlated CS Quality of Vision (QOV) scores. was measured under photopic (100 cd) mesopic (10 conditions 218 eyes 109 OAG aged < 60 years. The stages were divided into four groups according to mean deviation (MD) Humphrey Field Analyzer (HFA) 24 − 2 or 10 Swedish Interactive Thresholding Algorithm (SITA) standard, their examined. results Japanese version...
To investigate the relationships among postoperative metamorphopsia and macular morphological changes duration from onset of visual field disturbance to surgery (DVD) in patients who underwent for macula-off rhegmatogenous retinal detachment (RRD). We retrospectively reviewed 33 eyes pars plana vitrectomy (PPV) RRD with known symptoms at Niigata University Medical Dental Hospital or Saiseikai were followed up least 6 months postoperatively. Optical coherence tomography images macula obtained...
To evaluate the efficacy and safety of ripasudil for treatment secondary glaucoma, a historical cohort study was conducted at 18 centres in Japan. Adults (age ≥20 years) who needed additional IOP reduction received topical 0.4% between 2014 2018 due to three glaucoma subtypes, including uveitic (UG), exfoliation (EG) or steroid-induced (SG) were assessed mean change from baseline prior with ripasudil. We further evaluated each subtype, characteristics cohort, course uveitis-induced...
We examined ultrastructurally the localization of myocilin (formerly called trabecular meshwork inducible glucocorticoid response, or TIGR) protein in cultured human (TM) cells and normal TM tissues. The TM, a specialized tissue located at chamber angle eye, is believed to be responsible for development glaucoma. gene has been directly linked both juvenile primary open-angle glaucomas, multiple mutations have identified. Human were treated with 0.1 mM dexamethasone (DEX) induce expression....
Objectives To evaluate the vascular architecture of radial peripapillary capillaries (RPCs) and its relation with visual function in patients open-angle glaucoma (OAG) normal-tension using spectral-domain optical coherence tomography (SD-OCT) angiography. Subjects methods Clear OCT angiography images blood vessels optic disc retina were obtained from 52 (52 eyes) aged 55.42±10.64 (range 28–72) years primary OAG. The mean spherical equivalent was -3.19±2.31 diopters, deviation (MD) central...
Abstract Biallelic variants in the EYS gene are a major cause of autosomal recessive inherited retinal disease (IRD), with high prevalence Asian population. The purpose this study was to identify pathogenic variants, determine clinical/genetic spectrum -associated ( -RD), and discover disease-associated relatively allele frequency (1%-10%) nationwide Japanese cohort. Sixty-six affected subjects from 61 families biallelic or multiple pathogenic/disease-associated were ascertained by...
Abstract Inherited retinal disorder (IRD) is a leading cause of blindness, and CRX one number genes reported to harbour autosomal dominant (AD) recessive (AR) causative variants. Eighteen patients from 13 families with CRX-associated ( -RD) were identified 730 Japanese IRD. Ophthalmological examinations phenotype subgroup classification performed. The median age onset/latest examination was 45.0/62.5 years (range, 15–77/25–94). visual acuity in the right/left eye 0.52/0.40...