A5050094598- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Corneal surgery and disorders
- Optical Coherence Tomography Applications
- Ophthalmology and Eye Disorders
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Retinal and Macular Surgery
- Ophthalmology and Visual Impairment Studies
- Cerebral Venous Sinus Thrombosis
- Intraocular Surgery and Lenses
- Ocular Surface and Contact Lens
- Neurogenesis and neuroplasticity mechanisms
- Photoreceptor and optogenetics research
- Ocular Diseases and Behçet’s Syndrome
- Photochromic and Fluorescence Chemistry
- Neurological Disorders and Treatments
- Ocular Oncology and Treatments
- Acute Ischemic Stroke Management
- melanin and skin pigmentation
- Ocular Infections and Treatments
- Neuroscience and Neuropharmacology Research
- Retinopathy of Prematurity Studies
- Nerve injury and regeneration
Kyoto University
2015-2025
Niigata University
2021-2025
Niigata University Medical and Dental Hospital
2023-2025
University of California, San Diego
2017-2019
Smith-Kettlewell Eye Research Institute
2018
University of San Diego
2017-2018
Canon (Japan)
2012
Japan Society for the Promotion of Science
2012
Nidek (Japan)
2012
Topcon (Japan)
2012
It has long been believed that the retina of mature mammals is incapable regeneration. In this study, using N -methyl- d -aspartate neurotoxicity model adult rat retina, we observed some Müller glial cells were stimulated to proliferate in response a toxic injury and produce bipolar rod photoreceptors. Although these newly produced neurons limited number, retinoic acid treatment promoted number regenerated cells. Moreover, misexpression basic helix–loop–helix homeobox genes induction...
Regeneration in the mammalian CNS is severely limited. Unlike chick, current models hold that retinal neurons are never regenerated. Previously we demonstrated that, adult retina, Müller glia dedifferentiate and produce cells, including photoreceptors, after acute neurotoxic injury vivo. However, number of newly generated very Here demonstrate Wnt (wingless-type MMTV integration site family)/beta-catenin signaling promotes proliferation glia-derived progenitors neural regeneration damage or...
To investigate the relationship between cystoid spaces in outer plexiform layer (OPL) and characteristics of photoreceptors beneath patients with diabetic macular edema (DME).In this observational cross-sectional study, 123 eyes 96 consecutive clinically significant were retrospectively reviewed. The on optical coherence tomography (OCT) images represented by external limiting membrane (ELM) junction inner segments (IS/OS), their association overlying investigated.The areas OPL had a longer...
Optical coherence tomography angiography (OCT-A) is a noninvasive technology that allows visualization of retinal blood vessels. It important to determine reproducibility measurements as low precision can impair its diagnostic capabilities. The purpose this study intravisit and intervisit optic nerve head (ONH) macular vessel density with OCT-A.Fifteen healthy volunteers 14 glaucoma patients completed 2 OCT-A (AngioVue; Optovue Inc.) scanning sessions on each separate days assess...
Purpose.: To test the glaucoma-discriminating ability of a new method for detecting local ganglion cell loss using spectral-domain optical coherence tomography (OCT). Methods.: This study included 58 glaucomatous and 48 healthy eyes from Japanese subjects. Combined thickness layer inner plexus (GCIPL) was measured on macular cube scan in Cirrus HD-OCT. Average GCIPL within elliptical annulus minimum 360 spokes extending to outer radius were calculated. Area under receiver operating...
To compare the retinal nerve fiber layer (RNFL) defects in early glaucomatous eyes between highly and non-highly myopic eyes.Sixty-one (< -6.0 diopters [D]) of 61 patients 55 with visual field (VF) were studied. The angular locations widths RNFL measured from red-free fundus photographs. defect closest to fovea was designated "nearest defect" each hemisphere.In total, 131 found 82 eyes. Twenty-seven (44.3%) eyes, but only 8 (14.5%) had their nearest 0° 10° (P < 0.001). Although frequencies...
Purpose: To evaluate the association between macula vascular density assessed by optical coherence tomography angiography (OCT-A) and central visual field (VF) threshold sensitivities in healthy, glaucoma suspect, patients. Methods: A total of 185 eyes from 38 healthy participants, 31 suspects, 72 mild patients, 44 moderate/severe patients Diagnostic Innovations Glaucoma Study who underwent OCT-A images 10-2 VF testing were enrolled this observational cross-sectional study. The relationship...
PurposeTo investigate conjunctival and intrascleral vasculatures using anterior segment optical coherence tomography angiography (AS-OCTA) in normal eyes.DesignCross-sectional study.MethodsAS-OCTA images of the corneal limbus were acquired circumferentially a swept-source system 10 eyes healthy subjects. AS-OCTA flow patterns with en face maximum projection compared between superficial (from epithelium to depth 200 μm) deep μm 1000 layers. The OCTA also fluorescein scleral indocyanine green...
Retinal precursor cells give rise to six types of neurons and one type glial cell during development, this process is controlled by multiple basic helix-loop-helix (bHLH) genes. However, the precise mechanism for specification retinal neuronal subtypes, particularly horizontal photoreceptors, remains be determined. Here, we examined retinas with three different combinations triple bHLH gene mutations. In lacking genes Ngn2, Math3, NeuroD, as well other such bipolar were severely decreased in...
To visualize lamina cribrosa defects using three-dimensional (3D) swept-source optical coherence tomography (SS-OCT), and to determine the factors associated with this feature.All subjects were examined an SS-OCT prototype system, which uses a tunable laser as light source, operated at 100,000 Hz A-scan repetition rate in 1050-nm wavelength. A 3D raster scan protocol consisting of 256×256 A-scans was acquired over square area 3 mm×3 mm centered on optic disc. En face sectioned volume serial...
To visualize and assess the surface-level pores of lamina cribrosa in patients with glaucoma by using a prototype adaptive optics scanning laser ophthalmoscopy (AOSLO) system.The numbers laminar were compared between color disc photography, (SLO) without AO, AOSLO. The pore area elongation index examined for correlation ocular parameters such as mean deviation, area, cup/disc ratio, ovality index, intraocular pressure (IOP), axial length AOSLO images.The 40 eyes (20 normal 20 glaucomatous)...
Purpose To investigate whether lamina cribrosa (LC) defects are associated with optic disc morphology in primary open angle glaucoma (POAG) eyes high myopia. Methods A total of 129 POAG patients and 55 age-matched control subjects myopia were evaluated. Three-dimensional scan images obtained by swept source optical coherence tomography used to detect LC defects. Radial B-scans infrared spectral domain measure β-peripapillary atrophy (PPA) lengths without Bruch's membrane (BM) (temporal,...
In Brief Purpose: To investigate the correlation between visual outcomes and preoperative hyperreflective foci in outer retinal layers seen on spectral domain optical coherence tomography images eyes that underwent vitrectomy for diabetic macular edema. Methods: We retrospectively reviewed 32 consecutive Ten had accumulated or many preoperatively; 22 did not have pathology. The logarithm of minimum angle resolution junction inner segments were studied groups. Results: Logarithm was...