A5083320456- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- RNA regulation and disease
- Cellular transport and secretion
- Ophthalmology and Eye Disorders
- Retinal and Optic Conditions
- Ocular Surface and Contact Lens
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Ocular Diseases and Behçet’s Syndrome
- Complement system in diseases
- Glycosylation and Glycoproteins Research
- Nutrition and Health in Aging
- TGF-β signaling in diseases
- Phagocytosis and Immune Regulation
- Gestational Trophoblastic Disease Studies
- Muscle metabolism and nutrition
- Trace Elements in Health
- Cerebrovascular and genetic disorders
- Immune Cell Function and Interaction
- Xenotransplantation and immune response
- Sphingolipid Metabolism and Signaling
- Biomedical Research and Pathophysiology
- Ocular Disorders and Treatments
National Institute of Infectious Diseases
2025
Tokyo Medical Center
2012-2024
The University of Tokyo
2019-2024
University of Tokyo Hospital
2021-2023
Chiba University Hospital
2023
National Hospital Organization
2012-2022
Yotsuya Medical Cube
2022
Inserm
2021
Centre National de la Recherche Scientifique
2021
Institut du Cerveau
2021
Abstract Dendritic cells (DCs) are APCs that play an essential role by bridging innate and adaptive immunity. DC-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) is one of the major C-type lectins expressed on DCs exhibits high affinity for nonsialylated Lewis (Le) glycans. Recently, we reported characterization oligosaccharide ligands SW1116, a typical human colorectal carcinoma recognized mannan-binding protein, which serum lectin has similar...
Abstract Background Ready-to-eat meals are a vehicle of multijurisdictional outbreaks foodborne diseases worldwide. Ekiben is type ready-to-eat meal commonly sold at train stations and occasionally markets in Japan. On September 17, 2023, the Hachinohe City Public Health Center (HCPHC) received numerous complaints from consumers several prefectures who had eaten ekiben produced by Company A Hachinohe, Aomori, Methods In collaboration with HCPHC, we conducted an epidemiological investigation,...
To evaluate the efficacy and safety of ripasudil for treatment secondary glaucoma, a historical cohort study was conducted at 18 centres in Japan. Adults (age ≥20 years) who needed additional IOP reduction received topical 0.4% between 2014 2018 due to three glaucoma subtypes, including uveitic (UG), exfoliation (EG) or steroid-induced (SG) were assessed mean change from baseline prior with ripasudil. We further evaluated each subtype, characteristics cohort, course uveitis-induced...
Purpose: To determine the course of occult macular dystrophy (OMD, Miyake's disease) and to propose stages OMD based on optical coherence tomographic (OCT) findings. Methods: Sixty-one patients from 33 families with who carried one proven variants RP1L1 gene were studied at seven centers in Japan. Ophthalmological examinations including best-corrected visual acuity (BVCA) OCT performed. Results: The median age last visit was 50 years a range 10 88 years, symptom onset 30 3 60 years. There...
Abstract Biallelic variants in the EYS gene are a major cause of autosomal recessive inherited retinal disease (IRD), with high prevalence Asian population. The purpose this study was to identify pathogenic variants, determine clinical/genetic spectrum -associated ( -RD), and discover disease-associated relatively allele frequency (1%-10%) nationwide Japanese cohort. Sixty-six affected subjects from 61 families biallelic or multiple pathogenic/disease-associated were ascertained by...
Abstract Inherited retinal disorder (IRD) is a leading cause of blindness, and CRX one number genes reported to harbour autosomal dominant (AD) recessive (AR) causative variants. Eighteen patients from 13 families with CRX-associated ( -RD) were identified 730 Japanese IRD. Ophthalmological examinations phenotype subgroup classification performed. The median age onset/latest examination was 45.0/62.5 years (range, 15–77/25–94). visual acuity in the right/left eye 0.52/0.40...
Abstract This study investigated the effects of omidenepag (OMD), a novel selective EP2 receptor agonist, on human trabecular meshwork (HTM) cells, monkey Schlemm’s canal endothelial (SCE) and porcine ciliary muscle (CM) to clarify mechanism intraocular pressure (IOP) reduction involving conventional outflow pathway. In HTM SCE OMD transforming growth factor-β2 (TGF-β2)-induced changes were examined. The expression actin cytoskeleton extracellular matrix (ECM) proteins, myosin light chain...
Glutamate excitotoxicity is involved in retinal ganglion cell (RGC) death various degenerative diseases, including ischemia-reperfusion injury and glaucoma. Excitotoxic RGC caused by both direct damage to RGCs indirect through neuroinflammation of glial cells. Omidenepag (OMD), a novel E prostanoid receptor 2 (EP2) agonist, recently approved intraocular pressure-lowering drug. The second messenger EP2 cyclic adenosine monophosphate (cAMP), which activates protein kinase A (PKA) exchange...
To report the ocular characteristics of neuronal intranuclear inclusion disease (NIID)-related retinopathy with expansion CGG repeats in NOTCH2NLC gene.Seven patients from six families (aged 66-81 years) diagnosed adult-onset NIID were studied. Ophthalmologic examinations, including best-corrected visual acuity (BCVA), Goldmann perimetry, fundus photography, autofluorescence (FAF) imaging, optical coherence tomography (OCT), and full-field electroretinography (ERGs), performed. The gene was...
Abstract Jacalin, an α-O-glycoside of the disaccharide Thomsen-Friedenreich antigen (galactose β1-3 N-acetylgalactosamine, T-antigen)-specific lectin from jackfruit seeds, has been shown to induce mitogenic responses and block infection by HIV-1 in CD4+ T lymphocytes. The molecular mechanism underlying Jacalin-induced cell activation not elucidated completely yet. In present study, protein tyrosine phosphatase (PTPase) CD45 was isolated a Jurkat membrane fraction as major receptor for...
Full-field electroretinograms (ERGs) are used to evaluate retinal function in patients with various types of hereditary and acquired diseases. However, ERG recordings require relatively invasive procedures, including pupillary dilation the use contact lens electrodes. Thus, it would be helpful have a simpler noninvasive screening method. The purpose this study was determine whether new, handheld, portable device, RETeval™, can screen for cone dysfunction.Thirty-five eyes 35 who had reduced...
Purpose: To determine the clinical and genetic characteristics of patients with GUCY2D-associated retinal disorder (GUCY2D-RD). Methods: Fifteen from 12 families inherited (IRD) harboring GUCY2D variants were ascertained 730 Japanese IRD. Comprehensive ophthalmological examinations, including visual acuity (VA) measurement, imaging, electrophysiological assessment performed to classify into three phenotype subgroups; macular dystrophy (MD), cone-rod (CORD), Leber congenital amaurosis (LCA)....
We report here a case of fungal keratitis caused by Aspergillus viridinutans, member the genus which was found to have clinical and antifungal susceptibility characteristics distinct from species it most closely resembles, fumigatus. A 26-year-old woman presented with contact lens-associated keratitis, etiologic agent initially slow growing be resistant amphotericin B voriconazole. Therapeutic keratoplasty performed an isolate corneal scraping identified as A. viridinutans through partial...
Abstract Serum C-type lectin MBP is shown to bind DNA and RNA from bacteria, plasmids, synthetic oligonucleotides, fragmented of apoptotic cells via its carbohydrate recognition domain. MBP, also known as MBL, a that be soluble host defense factor involved in innate immunity. It has been well established dying microbes release highly viscous induces inflammation septic shock, display on their surfaces. However, PRRs mediate the clearance free have not characterized clearly. Although was...
PurposeTo clarify the genetic and clinical features of Japanese patients with ABCA4-associated retinopathy.DesignRetrospective, multicenter cohort studyMethodsPatients retinal degeneration biallelic ABCA4 variants were recruited from 13 different hospitals. Whole exome sequencing analysis was used for testing. Comprehensive ophthalmic examinations performed on matched patients. The primary outcome measure identifying multimodal imaging findings associated disease progression.ResultsThis...
To describe the functional phenotypic features of East Asian patients with RP1L1-associated occult macular dystrophy (ie, Miyake disease).An international multicenter retrospective cohort study.Twenty-eight participants (53 eyes) disease were enrolled at 3 centers (in Japan, China, and South Korea). Ophthalmologic examinations including spectral-domain optical coherence tomography (SDOCT) multifocal electroretinogram (mfERG) performed. Patients classified into groups based on mfERG: Group 1,...