A5081150325- Retinal Development and Disorders
- Retinal and Macular Surgery
- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Photoreceptor and optogenetics research
- Ocular and Laser Science Research
- Retinal Imaging and Analysis
- Ocular Diseases and Behçet’s Syndrome
- Neuroscience and Neural Engineering
- Visual perception and processing mechanisms
- Cerebral Venous Sinus Thrombosis
- Reinforcement Learning in Robotics
- Optimization and Search Problems
- Neuroscience and Neuropharmacology Research
- Retinopathy of Prematurity Studies
- Corneal surgery and disorders
- Vascular Malformations Diagnosis and Treatment
- Ocular Surface and Contact Lens
- Ophthalmology and Visual Impairment Studies
- Cervical Cancer and HPV Research
- Ophthalmology and Eye Disorders
- Ocular Infections and Treatments
- Ocular Disorders and Treatments
Fujita Health University Hospital
2002-2025
Fujita Health University
2015-2024
Kanagawa University
2012-2021
Ophthalmology Associates (United States)
2005-2020
Chiba University
2001-2019
University of Nevada, Las Vegas
2019
University of Chinese Academy of Sciences
2019
Central China Normal University
2019
Kyushu University
2007
National Institute of Technology, Yuge College
2007
To evaluate efficacy and safety of intravitreal injections aflibercept (IVT-AFL) treat-and-extend (T&E) dosing regimens in treatment-naïve patients with exudative age-related macular degeneration (AMD). Adults aged at least 50 years old AMD best-corrected visual acuity (BCVA) 73–25 Early Treatment Diabetic Retinopathy Study (ETDRS) letters were included. Patients received three monthly doses IVT-AFL 2 mg. At week 16, randomized 1:1 to T&E either 2- or 4-week adjustments. The primary endpoint...
We have developed a technique of staining the anterior capsule with solution indocyanine green that facilitates performance circular continuous capsulorrhexis in eyes mature cataract. compared results phacoemulsification and intraocular lens implantation 10 stained having same procedure standard capsulorrhexis. The specular microscopy laser flare-cell photometry showed no statistically significant differences between 2 groups. Although safety dye has not yet been definitively established,...
Inherited retinal diseases (IRDs) comprise a phenotypically and genetically heterogeneous group of ocular disorders that cause visual loss via progressive degeneration. Here, we report the genetic characterization 1210 IRD pedigrees enrolled through Japan Eye Genetic Consortium analyzed by whole exome sequencing. The most common phenotype was retinitis pigmentosa (RP, 43%), followed macular dystrophy/cone- or cone-rod dystrophy (MD/CORD, 13%). In total, 67 causal genes were identified in 37%...
Basic fibroblast growth factor (bFGF) stimulates angiogenesis and induces neural cell regeneration. We investigated the effects of bFGF on diabetic neuropathy in streptozotocin-induced rats. Diabetic rats were treated with human recombinant as follows: 1) intravenous administration, 2) intramuscular injection into thigh soleus muscles cross-linked gelatin hydrogel (CGH), 3) saline. Ten or 30 days later, motor nerve conduction velocity (MNCV) sciatic-tibial caudal nerves, sensitivity to...
Abstract Biallelic variants in the EYS gene are a major cause of autosomal recessive inherited retinal disease (IRD), with high prevalence Asian population. The purpose this study was to identify pathogenic variants, determine clinical/genetic spectrum -associated ( -RD), and discover disease-associated relatively allele frequency (1%-10%) nationwide Japanese cohort. Sixty-six affected subjects from 61 families biallelic or multiple pathogenic/disease-associated were ascertained by...
Abstract Inherited retinal disorder (IRD) is a leading cause of blindness, and CRX one number genes reported to harbour autosomal dominant (AD) recessive (AR) causative variants. Eighteen patients from 13 families with CRX-associated ( -RD) were identified 730 Japanese IRD. Ophthalmological examinations phenotype subgroup classification performed. The median age onset/latest examination was 45.0/62.5 years (range, 15–77/25–94). visual acuity in the right/left eye 0.52/0.40...
To determine the compliance with face-down positioning (FDP) of patients who had undergone vitrectomy and gas tamponade.One hundred twenty-seven patients, 45 females 82 males, primary tamponade for rhegmatogenous retinal detachments were studied. The FDP score was determined as 4 per day 3 days after surgery. patient given a one if nurse found that in zero not FDP. A perfect 12.The mean ± SD 10.2 1.8 range to 12. Females (10.7 1.2) scored significantly higher than males (9.9 2.1)...
Introduction The ability to reduce illumination levels is generally accepted as one of the main benefits a three-dimensional heads-up system (3D system: Ngenuity®; Alcon, CA, USA). Some studies have focused on reduction in vitreoretinal procedures; however, information regarding cataract surgery has not been published. Purpose This study aimed compare operational field with 3D and standard microscope eyepiece during surgery. Subject methods We retrospectively evaluated 91 eyes 84 consecutive...
We describe five unrelated patients in whom the typical signs of fundus albipunctatus were accompanied by colour vision defects, bull9s eye or similar macular lesions, and severely diminished full-field cone electroretinograms indicating widespread damage to cones outside macula. All had noticed night blindness from childhood. Signs retinitis punctata albescens, a disease appearance but with characteristics resembling pigmentosa, absent. cannot be sure whether these represent process...
To determine whether intraocular cooling using room-temperature irrigating solution can cause abnormal electroretinograph readings, we operated on six patients with premacular fibrosis and minimal retinal detachment, measuring the temperature in vitreous cavity an electroretinographic monitor. The dropped to 27 degrees C 28 after vitrectomies during which solutions were used. This resulted readings (markedly delayed peak times reduced amplitudes). These results suggest that routinely used...
Objective: To determine the elimination kinetics of indocyanine green (ICG) after intraocular operations using ICG staining.Methods: Intraocular fluorescence was determined angiographic mode a scanning laser ophthalmoscope (in vivo) and microscopy vitro) circular curvilinear capsulorhexis with staining during cataract surgery internal limiting membrane (ILM) peeling macular hole surgery. Subjects:We studied 9 eyes 7 patients white cataracts 14 idiopathic holes.Results: Scanning...
Photoreceptors and retinal bipolar cells are considered as nonspiking neurons; however, we recently showed that human rod photoreceptors can generate sodium action potentials in response to membrane depolarization from of -60 or -70 mV (Kawai et al., Neuron 30 [2001] 451). We performed patch-clamp recording cone examine whether functional voltage-gated channels expressed these well photoreceptors. Under current-clamp conditions, the injection depolarizing current steps into a...