A5038710773- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Allergic Rhinitis and Sensitization
- Intraocular Surgery and Lenses
- Retinal and Optic Conditions
- Ocular Infections and Treatments
- Dermatology and Skin Diseases
- Ophthalmology and Visual Impairment Studies
- Mast cells and histamine
- Retinal and Macular Surgery
- Cellular transport and secretion
- Retinal Imaging and Analysis
- Virus-based gene therapy research
- Advanced biosensing and bioanalysis techniques
- Urticaria and Related Conditions
- RNA regulation and disease
- Receptor Mechanisms and Signaling
- Cell Adhesion Molecules Research
- DNA and Nucleic Acid Chemistry
- Ocular Disorders and Treatments
- Connexins and lens biology
Juntendo University
2015-2024
Saitama International Medical Center
2021-2023
Kumamoto University Hospital
2023
Juntendo University Hospital
2006-2021
Toshiba (Japan)
2018
Kyoto Prefectural University of Medicine
1967-2013
Yokohama City University
2012-2013
Takeda Science Foundation
2013
Japan Society for the Promotion of Science
2013
Juntendo University Shizuoka Hospital
2013
We report the first quantum key distribution (QKD) systems capable of delivering sustainable, real-time secure keys continuously at rates exceeding 10 Mb/s. To achieve such rates, we developed high speed post-processing modules, achieving maximum data throughputs 60 MC/s, 55 Mb/s, and 108 Mb/s for standalone operation sifting, error correction privacy amplification respectively. The photonic layer QKD features high-speed single photon detectors based on self-differencing InGaAs avalanche...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHybridization of nucleic acids immobilized on a quartz crystal microbalanceYoshio Okahata, Yuka Matsunobu, Kuniharu Ijiro, Masayuki Mukae, Akira Murakami, and Keisuke MakinoCite this: J. Am. Chem. Soc. 1992, 114, 21, 8299–8300Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October 1992https://pubs.acs.org/doi/10.1021/ja00047a056https://doi.org/10.1021/ja00047a056research-articleACS...
Sphingosine 1-phosphate (S1P) induces diverse biological responses in various tissues by activating specific G protein-coupled receptors (S1P<sub>1</sub>–S1P<sub>5</sub> receptors). The signaling regulated S1P<sub>3</sub> receptor has not been fully elucidated because of the lack an receptor-specific antagonist or agonist. We developed a novel antagonist, 1-(4-chlorophenylhydrazono)-1-(4-chlorophenylamino)-3,3-dimethyl- 2-butanone (TY-52156), and show here that S1P-induced decrease coronary...
To investigate the role of IL-6 classic- and trans-signaling pathways in corneal sterile inflammation wound healing.To assess production inflammatory molecules by fibroblasts treated with supernatant derived from necrotic epithelial cells, authors used an antibody array. Expressions membrane receptor (mIL-6R) soluble IL-6R (SIL-6R) cells were detected flow cytometry RT-PCR. signal transducer activator transcription 3 (STAT3), vascular endothelial growth factor (VEGF), monocyte chemotactic...
Background The genetic profile of retinitis pigmentosa (RP) in East Asian populations has not been well characterised. Therefore, we conducted a large-scale sequencing study to investigate the genes and variants causing RP Japanese population. Methods A total 1209 patients diagnosed with typical were enrolled. We performed deep resequencing 83 known causative using next-generation sequencing. defined pathogenic as those that putatively deleterious or registered Human Gene Mutation Database...
Purpose/Aim of the Study. Subthreshold micropulse diode laser photocoagulation is an effective treatment for macular edema. The molecular mechanisms underlying success are poorly understood. Therefore, we investigated effects sublethal energy doses on a single layer densely cultured ARPE-19 cells as model human retinal pigment epithelium (RPE). Materials and Methods. A was perpendicularly irradiated with laser. Nonirradiated served controls. Sublethal applied to form photocoagulation-like...
The incidence of dry eye disease has increased; the potential for crowdsource data to help identify undiagnosed in symptomatic individuals remains unknown.To assess characteristics and risk factors associated with diagnosed using smartphone app DryEyeRhythm.A cross-sectional study crowdsourced was conducted including Japan who downloaded DryEyeRhythm completed entire questionnaire; duplicate users were excluded. released on November 2, 2016; from 2016, January 12, 2018.DryEyeRhythm collected...
Objectives The Ocular Surface Disease Index (OSDI) questionnaire is widely used to evaluate subjective symptoms of dry eye disease (DED) as a primary diagnostic criterion. This study aimed develop Japanese version the OSDI (J-OSDI) and assess its reliability validity. Design setting Hospital-based cross-sectional observational study. Participants A total 209 patients recruited from Department Ophthalmology at Juntendo University Hospital. Methods We translated culturally adapted into...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHybridization arrest of globin synthesis in rabbit reticulocyte lysates and cells by oligodeoxyribonucleoside methylphosphonatesKathleen R. Blake, Akira Murakami, Sharon A. Spitz, Scott Glave, M. Parameswara Reddy, Paul O. P. Ts'o, S. MillerCite this: Biochemistry 1985, 24, 22, 6139–6145Publication Date (Print):October 1, 1985Publication History Published online1 May 2002Published inissue 1 October 1985https://doi.org/10.1021/bi00343a016Request...
We assessed global inequality in eye health by using data on the burden of disease measured disability-adjusted life years (DALYs).We estimated calculating sum DALYs (from Global Burden Disease study, 2004 update) due to trachoma, vitamin A deficiency, glaucoma, cataract, refractive errors, and macular degeneration. geographic distribution relation economic status etiology Gini coefficient, Theil index, Atkinson index.The was at 61.4 million worldwide (4.0% total DALYs). Vitamin deficiency...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInhibition of rabbit globin mRNA translation by sequence-specific oligodeoxyribonucleotidesKathleen R. Blake, Akira Murakami, and Paul S. MillerCite this: Biochemistry 1985, 24, 22, 6132–6138Publication Date (Print):October 1, 1985Publication History Published online1 May 2002Published inissue 1 October 1985https://pubs.acs.org/doi/10.1021/bi00343a015https://doi.org/10.1021/bi00343a015research-articleACS PublicationsRequest reuse permissionsArticle...
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to reduce inflammation by suppressing cyclooxygenases (COXs). NSAID eye drops frequently prescribed after ocular surgery and pain, but this treatment has clinically significant side effects, including corneal ulcer perforation. The molecular mechanisms underlying these effects remain unknown. Recently, the COX product 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT) was identified as an endogenous ligand for leukotriene B4...
We have been using a differential cDNA cloning approach to isolate human retina‐specific and retina‐enriched genes [1]. A 1,314 bp was isolated by this approach, representing highly message encoding 388 amino acid protein showing 58%, 50%, 49% homology bovine β‐arrestin, retinal arrestin (S‐antigen), respectively. Chromosomal mapping localized new genc the proximal long arm of X chromosome, hence it named X‐arrestin. In situ hybridization demonstrated its expression in inner outer segments...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolid-phase synthesis of oligodeoxyribonucleoside methylphosphonatesPaul S. Miller, M. Parameswara Reddy, Akira Murakami, Kathleen R. Blake, Shwu Bin Lin, and Cheryl H. AgrisCite this: Biochemistry 1986, 25, 18, 5092–5097Publication Date (Print):September 1, 1986Publication History Published online1 May 2002Published inissue 1 September 1986https://pubs.acs.org/doi/10.1021/bi00366a017https://doi.org/10.1021/bi00366a017research-articleACS...
To investigate sequence variations in the optineurin (OPTN) gene and their association with TNF-alpha polymorphisms Japanese patients glaucoma.The OPTN was analyzed blood samples from 629 subjects. There were 194 primary open-angle glaucoma (POAG), 217 normal-tension (NTG), 218 no eye disease (control subjects). The screened for mutations by denaturing high-performance liquid chromatography. Genotyping of three -308G-->A, -857C-->T, -863C-->A promoter region performed. associations between...