A5011467881- Ocular Surface and Contact Lens
- Allergic Rhinitis and Sensitization
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Dermatology and Skin Diseases
- Corneal surgery and disorders
- Olfactory and Sensory Function Studies
- Ocular Infections and Treatments
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Ocular Oncology and Treatments
- Mast cells and histamine
- Contact Dermatitis and Allergies
- Skin Protection and Aging
- Cerebral Venous Sinus Thrombosis
- Cancer and Skin Lesions
- Vestibular and auditory disorders
- Immunotherapy and Immune Responses
- Neural dynamics and brain function
- Retinal Imaging and Analysis
- Neurotransmitter Receptor Influence on Behavior
- Retinal Diseases and Treatments
- Acne and Rosacea Treatments and Effects
- Advancements in Transdermal Drug Delivery
- Circadian rhythm and melatonin
Juntendo University
2018-2024
Massachusetts Eye and Ear Infirmary
2021-2022
Harvard University
2021-2022
Juntendo University Shizuoka Hospital
2018-2022
Juntendo University Hospital
2018
The incidence of dry eye disease has increased; the potential for crowdsource data to help identify undiagnosed in symptomatic individuals remains unknown.To assess characteristics and risk factors associated with diagnosed using smartphone app DryEyeRhythm.A cross-sectional study crowdsourced was conducted including Japan who downloaded DryEyeRhythm completed entire questionnaire; duplicate users were excluded. released on November 2, 2016; from 2016, January 12, 2018.DryEyeRhythm collected...
Discontinuation of contact lens use is mainly caused by lens-associated dry eye. It crucial to delineate eye's multifaceted nature tailor treatment each patient's individual needs for future personalized medicine.This paper aims quantify and stratify subjective symptoms eye clarify its risk factors medicine using the smartphone app DryEyeRhythm (Juntendo University).This cross-sectional study included iPhone (Apple Inc) users in Japan who downloaded DryEyeRhythm. was used collect medical big...
Multidimensional integrative data analysis of digital phenotyping is crucial for elucidating the pathologies multifactorial and heterogeneous diseases, such as dry eye (DE). This crowdsourced cross-sectional study explored a novel smartphone-based strategy to stratify visualize heterogenous DE symptoms into distinct subgroups. were collected from 3,593 participants between November 2016 September 2019. Dimension reduction via Uniform Manifold Approximation Projection stratified seven...
Introduction The number of cataract surgeries, the most common ophthalmic surgery, is expected to increase due ageing populations. Dry eye disease (DED) a frequent side effect contributing lower postoperative patient satisfaction and suboptimal quality vision. It unclear which eye-drops commonly used in these patients should be recommended for DED treatment. This study aims compare efficacy topical administration diquafosol sodium 3% vs hyaluronic acid 0.1% with after surgery. Methods...
Multidisciplinary efforts to prospectively collect and analyze symptoms of hay fever are limited. We aimed identify the characteristics nasal ocular fever, using AllerSearch smartphone application.This mobile health-based prospective observational study application was conducted between February 1, 2018, May 2020. Individuals who downloaded from Japan provided comprehensive self-assessments (including 17 items related quality life [QoL]-related items) were included. The risk factors for...
Dry eye disease (DED) is one of the most common ocular surface diseases. Numerous patients with DED remain undiagnosed and inadequately treated, experiencing various subjective symptoms a decrease in quality life work productivity. A mobile health smartphone app, namely, DEA01, has been developed as noninvasive, noncontact, remote screening device, context an ongoing paradigm shift care system, to facilitate diagnosis DED.This study aimed evaluate capabilities DEA01 app diagnosis.In this...
Abstract Background Hay fever is a common allergic disease, with an estimated worldwide prevalence of 14.4% and variety symptoms. This study assessed the minimal clinically important difference (MCID) nasal symptom score (NSS), non‐nasal (NNSS), total symptoms (TSS) for app‐based hay‐fever monitoring. Methods MCIDs were calculated based on data from previous large‐scale, crowdsourced, cross‐sectional using AllerSearch, in‐house smartphone application. determined anchor‐based...
Abstract Various symptoms of the dry eye disease (DED) interfere with quality life and reduce work productivity. Therefore, screening, prevention, treatment DED are important. We aimed to investigate potential diagnostic ability maximum blink interval (MBI) (the length time participants could keep their eyes open) disease-specific questionnaire for DED. This cross-sectional study included 365 patients (252 113 without DED) recruited between September 2017 December 2019. Discriminant validity...
Abstract Corneal allograft survival is mediated by the variety of immunological reactions and wound healing process. Our aim was to explore effects topical administration ripasudil, a selective Rho-associated coiled-coil protein kinase inhibitor, on corneal survival. Ripasudil administered mice thrice day after allogeneic transplantation. graft survival, opacity, neovascularization, re-epithelization, immune cell infiltration, mRNA levels angiogenic pro-inflammatory factors in grafted cornea...
To investigate the effects of ex vivo-induced bone marrow myeloid-derived suppressor cells (BM-MDSCs) on allogeneic immune responses in corneal transplantation.Bone from C57BL/6J (B6) mice were cultured with IL-6 and GM-CSF for four days. The vivo induction BM-MDSCs was assessed using flow cytometry, inducible nitric oxide synthase (iNOS) mRNA expression reverse transcription-quantitative polymerase chain reaction, (NO) production stimulation. T-cell proliferation regulatory (Treg) expansion...
Hay fever is a highly prevalent, heterogenous, and multifactorial disease. Patients may benefit from longitudinal assessments using mobile health (mHealth) principles. We have previously attempted to establish an effective mHealth platform for patients with hay through AllerSearch, our in-house smartphone app that assesses electronic patient-reported outcomes questionnaire on provides evidence-based advice. To be used by the public, investigation its reliability validity necessary.The aim of...
Using traditional patient-reported outcomes (PROs), such as paper-based questionnaires, is cumbersome in the era of web-based medical consultation and telemedicine. Electronic PROs may reduce burden on patients if implemented widely. Considering promising reports DryEyeRhythm, our in-house mHealth smartphone app for investigating dry eye disease (DED) electronic Ocular Surface Disease Index (OSDI) should be evaluated compared to determine their equivalency.