A5002923379- Ocular Surface and Contact Lens
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Glioma Diagnosis and Treatment
- Retinal and Optic Conditions
- Cancer-related molecular mechanisms research
- Retinal Imaging and Analysis
- Cancer Genomics and Diagnostics
- Plant Pathogens and Fungal Diseases
- Glaucoma and retinal disorders
- Olfactory and Sensory Function Studies
- MicroRNA in disease regulation
- Tuberous Sclerosis Complex Research
- Plant-Microbe Interactions and Immunity
- Ocular Infections and Treatments
- Contact Dermatitis and Allergies
- Meningioma and schwannoma management
- Corneal Surgery and Treatments
- Brain Metastases and Treatment
- Insects and Parasite Interactions
- Lung Cancer Treatments and Mutations
- Ion channel regulation and function
- Genetic and Kidney Cyst Diseases
- Mycorrhizal Fungi and Plant Interactions
- Retinal Diseases and Treatments
Xiangya Hospital Central South University
2014-2025
Central South University
2014-2025
Yale University
2015-2024
Juntendo University
2021-2024
Zhengzhou Fruit Research Institute
2021-2023
Chinese Academy of Agricultural Sciences
2021-2023
Erasmus University Rotterdam
2021-2022
University of Central Florida
2022
Florida State University
2022
South University
2022
Botryosphaeria dothidea causes apple ring rot, which is among the most prevalent postharvest diseases of apples and significant economic loss during storage. In this study, we investigated biocontrol activity possible mechanism Bacillus velezensis strain P2-1 isolated from branches against B. in fruit. The results showed P2-1, one 80 different endophytic bacterial strains branches, exhibited strong inhibitory effects growth resulted hyphal deformity. treatment significantly reduced rot...
Inhibiting filamin A has therapeutic effects in a model of tuberous sclerosis complex and subset focal cortical dysplasia.
Brain metastasis (BM) genetically diverges from the primary tumor in non‐small‐cell lung cancer (NSCLC). Hence, accurately capturing clinically relevant alterations is pivotal for delivery of targeted therapies. Circulating DNA (ctDNA) sequencing has emerged as a promising liquid biopsy biomarker‐based clinical management recurrent and extracranial metastatic NSCLC. However, absence simultaneous data brain sites prevents definitive evaluation efficacy ctDNA representing genetic profiles BM....
MicroRNA-128 (miR-128) serves an important role in regulating growth, invasiveness, stem cell-like traits, differentiation and apoptosis of different types tumor cells. Vascular endothelial growth factor-C (VEGF-C) has been associated with angiogenesis, lymphangiogenesis regional lymph node metastasis previously reported to have anti-apoptotic proliferative bladder cancer (BC). To investigate the regulation miR-128 on VEGF-C expression their effects proliferation cancer, T24 5637 BC cells...
Abstract Tremendous efforts have been made to explore biomarkers for classification and grading on gliomas. The goal of this study was identify more molecular features that are associated with clinical outcomes by comparing the genomic profiles primary recurrent gliomas determine potential recurrence leading factors significantly enriched in relapse tumors. Hybrid capture based next generation sequencing (NGS) analysis performed 64 17 glioma biopsies. Copy number variation (CNV) frequent...
Pear Valsa canker caused by pyri is among the most destructive diseases of pear, which causes significant economic loss. The present study was developed to explore biocontrol efficiency and underlying antagonistic mechanism Paenibacillus polymyxa strain Nl4 against V. pyri. P. Nl4, one 120 different endophytic bacterial strains from pear branches, exhibited strong inhibitory effects mycelial growth hyphal malformation. Culture filtrate derived able effectively suppress pyri, found exhibit...
Abnormal axonal connectivity and hyperactive mTOR complex 1 (mTORC1) are shared features of several neurological disorders. Hyperactive mTORC1 alters axon length polarity hippocampal neurons in vitro, but the impact on growth vivo mechanisms underlying those effects remain unclear. Using utero electroporation during corticogenesis, we show that increasing activity accelerates without multiple formation. This was prevented by counteracting signaling through p70S6Ks (S6K1/2) or eukaryotic...
Apple ring rot, one of the most common apple postharvest diseases during storage, is caused by Botryosphaeria dothidea. Fungicide application widely used method to control this disease, but increasing environmental and food safety concerns greatly limit their use. The present study aimed examine biocontrol activity underlying action mechanism Bacillus halotolerans strain Pl7 against B. results revealed that exhibited strong inhibitory dothidea 69% in vitro. culture filtrate possessed...
Dry eye disease (DED) is one of the most common ocular surface diseases. Numerous patients with DED remain undiagnosed and inadequately treated, experiencing various subjective symptoms a decrease in quality life work productivity. A mobile health smartphone app, namely, DEA01, has been developed as noninvasive, noncontact, remote screening device, context an ongoing paradigm shift care system, to facilitate diagnosis DED.This study aimed evaluate capabilities DEA01 app diagnosis.In this...
We report the clinical findings and molecular identification of ocular
Abstract Background Besides the hallmark of H3K27M mutation, aberrant amplifications receptor tyrosine kinases (RTKs) are commonly observed in diffuse midline glioma (DMG), a highly malignant brain tumor with dismal prognosis. Here, we intended to evaluate efficacy and safety multitarget RTK inhibitor anlotinib patients H3K27M‐DMG. Methods A total 40 newly diagnosed H3K27M‐DMG including 15 25 without treatment were retrospectively enrolled this cohort. Progression‐free survival (PFS),...
Multidisciplinary efforts to prospectively collect and analyze symptoms of hay fever are limited. We aimed identify the characteristics nasal ocular fever, using AllerSearch smartphone application.This mobile health-based prospective observational study application was conducted between February 1, 2018, May 2020. Individuals who downloaded from Japan provided comprehensive self-assessments (including 17 items related quality life [QoL]-related items) were included. The risk factors for...
Abstract Background Hay fever is a common allergic disease, with an estimated worldwide prevalence of 14.4% and variety symptoms. This study assessed the minimal clinically important difference (MCID) nasal symptom score (NSS), non‐nasal (NNSS), total symptoms (TSS) for app‐based hay‐fever monitoring. Methods MCIDs were calculated based on data from previous large‐scale, crowdsourced, cross‐sectional using AllerSearch, in‐house smartphone application. determined anchor‐based...
Introduction The number of cataract surgeries, the most common ophthalmic surgery, is expected to increase due ageing populations. Dry eye disease (DED) a frequent side effect contributing lower postoperative patient satisfaction and suboptimal quality vision. It unclear which eye-drops commonly used in these patients should be recommended for DED treatment. This study aims compare efficacy topical administration diquafosol sodium 3% vs hyaluronic acid 0.1% with after surgery. Methods...
Using traditional patient-reported outcomes (PROs), such as paper-based questionnaires, is cumbersome in the era of web-based medical consultation and telemedicine. Electronic PROs may reduce burden on patients if implemented widely. Considering promising reports DryEyeRhythm, our in-house mHealth smartphone app for investigating dry eye disease (DED) electronic Ocular Surface Disease Index (OSDI) should be evaluated compared to determine their equivalency.
Abstract Objectives Patients with mammalian target of rapamycin (mTOR) –dependent malformations cortical development ( MCD s) associated seizures display hyperperfusion and increased vessel density the dysmorphic tissue. Some studies have suggested that vascular defect occurred independently seizures. Here, we further examined whether hypervascularization occurs in animal models global focal without seizures, it is sensitive to mTOR blocker, rapamycin, approved for epilepsy treatment...