A5057442335- Ocular Surface and Contact Lens
- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- Allergic Rhinitis and Sensitization
- Pediatric health and respiratory diseases
- Congenital Heart Disease Studies
- Schizophrenia research and treatment
- Respiratory and Cough-Related Research
- Olfactory and Sensory Function Studies
- Gastric Cancer Management and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Dermatology and Skin Diseases
- Antibiotic Use and Resistance
- Exercise and Physiological Responses
- Healthcare and Venom Research
- Antibiotic Resistance in Bacteria
- Dementia and Cognitive Impairment Research
- Pharmacological Effects of Natural Compounds
- Gastrointestinal Tumor Research and Treatment
- Phenothiazines and Benzothiazines Synthesis and Activities
- Pulmonary Hypertension Research and Treatments
- Pharmacy and Medical Practices
- Glaucoma and retinal disorders
- Drug-Induced Adverse Reactions
- Mycobacterium research and diagnosis
Juntendo University
2014-2025
Meitetsu Hospital
2024
Juntendo University Hospital
2009-2024
Red Cross Hospital
2019-2024
Saitama International Medical Center
2021-2023
Hitachi (Japan)
1990-2023
Edogawa Hospital
2023
Toho University
1993-2021
Eisai (Japan)
2018-2021
Forestry and Forest Products Research Institute
2021
Studies show evidence of longitudinal brain volume decreases in schizophrenia. We studied changes and their relation to symptom severity, level function, cognition, antipsychotic medication participants with schizophrenia control from a general population based birth cohort sample relatively long follow-up period almost decade. All members the Northern Finland Birth Cohort 1966 any psychotic disorder random not having psychosis were invited for MRI scan, clinical cognitive assessment during...
Objectives The Ocular Surface Disease Index (OSDI) questionnaire is widely used to evaluate subjective symptoms of dry eye disease (DED) as a primary diagnostic criterion. This study aimed develop Japanese version the OSDI (J-OSDI) and assess its reliability validity. Design setting Hospital-based cross-sectional observational study. Participants A total 209 patients recruited from Department Ophthalmology at Juntendo University Hospital. Methods We translated culturally adapted into...
Background: Prostitutes are at high risk of unintended pregnancy, and induced abortions widely practised among this cohort.Aims: This study examined the effects prostitution bans on prevalence abortions. We focused particularly juvenile prostitution, which were introduced by 32 states Japan between 1975 1998.Methods: was a cross-sectional employing event-study analyses difference-in-difference-in-differences methodology. compared changes in numbers before after introduced, women under 20...
Centella asiatica, a traditional medicinal plant, possesses potent antioxidant activity and may therefore prevent cellular aging exert antiapoptotic effects. However, these effects remain to be fully elucidated. This study aimed investigate the protective of C. asiatica extract against senescence apoptosis caused by hydrogen peroxide (H2O2)-induced oxidative stress in human epidermal keratinocytes (HaCaT cells). To evaluate H2O2 on HaCaT cells, we measured cell viability as marker death;...
Eye washing is a common over-the-counter, self-administered method for managing hay fever-related ocular symptoms. However, epidemiological data on eyewash users with fever and their characteristics are limited. This study aimed to profile usage preferences in individuals fever. digital, cross-sectional cohort was conducted between February 2018 May 2020. Individuals Japan who downloaded the AllerSearch smartphone application were included. Factors associated non-eyewash among patients...
Inhaled nitric oxide (NO) has been shown to reduce the mean pulmonary artery pressure (mPAP) and improve PaO2 in patients with acute respiratory failure undergoing oxygen (O2) therapy. However, inhaled NO reduced hypertension without improving chronic obstructive disease (COPD). This study was intended compare hemodynamic gas exchange responses during inhalation of or O2 those observed combined 10 spontaneously breathing COPD patients. Hemodynamic blood parameters were measured after...
In the rituximab era, several large studies have suggested that full-dose plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) might be best treatment for patients with diffuse B-cell lymphoma (DLBCL) aged 60 years older. However, it remains unclear whether this is also case those 70 Previously untreated DLBCL older (elderly) were treated R-70%CHOP, younger than (younger) R-CHOP every 3 weeks, a total of 6-8 cycles. Complete remission (CR) rates in elderly versus 75 vs....
Abstract Background Hay fever is a common allergic disease, with an estimated worldwide prevalence of 14.4% and variety symptoms. This study assessed the minimal clinically important difference (MCID) nasal symptom score (NSS), non‐nasal (NNSS), total symptoms (TSS) for app‐based hay‐fever monitoring. Methods MCIDs were calculated based on data from previous large‐scale, crowdsourced, cross‐sectional using AllerSearch, in‐house smartphone application. determined anchor‐based...
Abstract Introduction We studied the mortality risk of long term and new antipsychotic drug use in Alzheimer's disease (AD) patients Japan to determine improved treatment protocols. Methods This 24‐week prospective cohort study included 10,079 Japanese AD (female, 69%; average age, 81 years) under routine clinical care 357 medical sites. The medication history was varied (63.7% were long‐term users). Mortality rates odds ratio analyzed (initial 10 weeks from 11–24 weeks). Results exposed...
Using traditional patient-reported outcomes (PROs), such as paper-based questionnaires, is cumbersome in the era of web-based medical consultation and telemedicine. Electronic PROs may reduce burden on patients if implemented widely. Considering promising reports DryEyeRhythm, our in-house mHealth smartphone app for investigating dry eye disease (DED) electronic Ocular Surface Disease Index (OSDI) should be evaluated compared to determine their equivalency.
To clarify the characteristic radiographic findings and serial changes in nonsurgical cases of intestinal Behçet disease (BD), seven patients were followed up for an average 4 1/2 years (range, 8 months to 11 months). They underwent repeated examination with barium meal studies double-contrast enema radiography. Initial radiography revealed one three deep ulcers terminal ileum or ileocecal region five patients. The healed while treated medical therapy but recurred during follow-up period. In...
The aim of this study was to determine whether low-dose inhalation nitric oxide (NO) improves pulmonary haemodynamics and gas exchange in patients with stable idiopathic fibrosis (IPF). investigation included 10 IPF breathing spontaneously. Haemodynamic blood parameters were measured under the following conditions: 1) room air; 2) during 2 parts per million (ppm) NO 3) whilst O2 alone (1 L.min-1); 4) combined ppm L.min-1). During air mean arterial pressure (Ppa 25 +/- 3 vs 30 4 mmHg)...
Abstract Aims It remains debatable whether early intervention for psychosis is capable of meeting the needs at‐risk subjects. The aims this study were to describe actual impact interventions on subjective difficulties and explore factors that may be associated with a poor outcome. Methods Participants help‐seeking outpatients at university hospital who met C riteria P rodromal S yndromes. Changes in symptoms, experience current insight assessed using cales ymptoms, ubjective W ell‐being...
Abstract Aim A recent study demonstrated that FoxO3a was directly induced by the overexpression of Hsp72 in rat soleus muscle. However, whether heat stress treatment induces phosphorylation skeletal muscle remains unclear. This examined effects on regulation signalling pathway Methods Thirty‐two male Wistar rats (15 weeks old) were randomly assigned into two groups; sedentary control group (Sed, n = 8) and experimental ( 24). After an overnight fast, one leg each HS leg) immersed hot water...
We have developed a new method for Staphylococcus aureus (S. aureus) detection, which employs fluorescent silica nanoparticles (FSiNPs) modified with metal–dipicolylamine complex (M-dpa-HCC). Among the M-dpa-HCC/FSiNP complexes, Cu-dpa-HCC/FSiNP formed large aggregates S. in 10 min, were easily observed by naked eye. The antibacterial activity of was also confirmed.
We examined the impact of 5-aminolevulinic acid (5-ALA) and sodium-ferrous-citrate supplementation on aerobic capacity redox balance through a placebo-controlled, double-blind trial. Fourteen healthy volunteers were randomly assigned to Pla + ALA (4-week placebo followed by 4-week 5-ALA supplementation) or supplement placebo) group administered (25 mg/day) once daily. The participants underwent submaximal incremental cycling tests at weeks 0, 2, 4, 6, 8. In test week individual...
This retrospective study aimed to determine the optimal cutoff values of Dry Eye-Related Quality-of-Life Score (DEQS) questionnaire for diagnosing dry eye disease (DED) and classifying DED severities. Participants completed DEQS questionnaire, Japanese version Ocular Surface Disease Index (J-OSDI) examinations. was diagnosed according 2016 Asia Eye Society diagnostic criteria based on symptoms (J-OSDI ≥ 13 points) tear film breakup time ≤ 5 s. Receiver operating characteristic (ROC) analysis...