A5052247265- Schizophrenia research and treatment
- Mental Health and Psychiatry
- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Mental Health Treatment and Access
- Child and Adolescent Psychosocial and Emotional Development
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Psychosomatic Disorders and Their Treatments
- Bipolar Disorder and Treatment
- Migration, Health and Trauma
- Obsessive-Compulsive Spectrum Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Personality Disorders and Psychopathology
- Polyamine Metabolism and Applications
- Family Caregiving in Mental Illness
- Tryptophan and brain disorders
- Autism Spectrum Disorder Research
- Amino Acid Enzymes and Metabolism
- Neuroscience and Music Perception
- Dementia and Cognitive Impairment Research
- Grief, Bereavement, and Mental Health
- Eating Disorders and Behaviors
- Racial and Ethnic Identity Research
- Migration and Labor Dynamics
Toho University
2016-2025
Tokyo Metropolitan Matsuzawa Hospital
2021
Saiseikai Ibaraki Hospital
2021
Osaka Police Hospital
2010-2011
The University of Tokyo
2000-2011
Keio University
2002-2009
Neurobehavioral Systems
2009
VA Greater Los Angeles Healthcare System
2009
Keio University Hospital
2008
Azumi Hospital
2003-2006
Abstract Machine learning approaches using structural magnetic resonance imaging (sMRI) can be informative for disease classification, although their ability to predict psychosis is largely unknown. We created a model with individuals at CHR who developed later (CHR-PS+) from healthy controls (HCs) that differentiate each other. also evaluated whether we could distinguish CHR-PS+ those did not develop (CHR-PS-) and uncertain follow-up status (CHR-UNK). T1-weighted brain MRI scans 1165...
Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. However, the extent of neuroanatomical CHR-P state is largely undetermined. We aimed to quantify structural magnetic resonance imaging measures cortical surface area (SA), thickness (CT), subcortical volume (SV), intracranial (ICV) individuals compared with healthy controls (HC), relation subsequent transition a first episode psychosis. The ENIGMA consortium applied...
Background: Research from Western countries shows an increased trend of Anorexia Nervosa (AN) among children and adolescents after the COVID-19 pandemic. However, in other remains unclear. This study aimed to examine association pan-demic with newly diagnosed AN Japan. Methods: Using nationwide multi-hospital database Japan, we analyzed clinical outpatient data de-partments pediatrics, psychosomatic medicine, psychiatry. The participants comprised aged 7-19 years January 2017 2022. An...
Objective Impact of Diagnostic and Statistical Manual Mental Disorders, Fifth Edition (DSM-5) changes on the criteria for schizophrenia (SZ) has been reported to be minimal in previous studies. However, this could different first-episode spectrum disorders (FE-SSDs). We investigated what proportion patients with FE-SSDs was diagnosed based sole presence bizarre delusions (BDs) or first rank auditory hallucinations (FRAHs). Their alternative diagnosis by DSM-5 established diagnostic stability...
Background and Objectives: The COVID-19 pandemic globally has negative effects on mental health. Research from Western countries, such as the US, Canada, Australia, Europe, shows that is associated with an increased trend of anorexia nervosa (AN) among children adolescents. However, after in Eastern including Japan, not well-understood, it remains unclear whether these countries. This study aimed to examine association between newly diagnosed AN adolescents Japan. Materials Methods: Using...
Yuji Yamada, Naoko Kishimoto, Hiromi Tagata, Tsubasa Morimoto, Kazuho Tomimoto, Yutaro Sato, Yuko Higuchi, Hiroshi Hiejima, Hayato Ohshima, Takao Kato, Mari S. Oba, Shoki Izumi, Yui Tomo, Shingo Kitamura, Andrew Stickley, Toshifumi Takahiro Nemoto, Masafumi Mizuno, Hiroaki Tomita, Michio Suzuki, Motohiro Ozone, Kenji Hashimoto, Kazuo Mishima, Takashi Ohnishi, Kazuyuki Nakagome, Tomiki Sumiyoshi. Clin Psychopharmacol Neurosci -0001;0:. https://doi.org/10.9758/cpn.24.1258
The present study examined three kinds of subjective assessment scales in the same patient group with schizophrenia to analyze correlations among scores obtained relation background data.Thirty-six patients were 26-item short form World Health Organization Quality Life (WHO-QOL 26), Subjective Well-being under Neuroleptic drug treatment: Short Japanese version (SWNS) and Self-Efficacy for Community scale (SECL) scales, five neurocognitive tests, Positive Negative Syndrome Scale (PANSS)...
Abstract Background The mode of onset and the course schizophrenia illness exhibit substantial individual variations. Previous studies have pointed out that affects duration untreated psychosis (DUP) clinical outcomes, such as cognitive social functioning. This study attempted to clarify association between DUP features, taking different modes into consideration, in a prospective longitudinal examining patients with first-episode schizophrenia. Methods was conducted six areas Japan. Patients...
Abstract Aims Improving mental health literacy through school‐based education may encourage promotion, prevention and care reduce stigma in adolescents. In Japan, instruction about illness has been formulated a Course of Study that reflects governmental curriculum guidelines, which will be enforced from 2022 to promote an understanding current issues adolescent health. Educational resources available schoolteachers have developed. This article describes the development processes contents...
Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes/vacuoles. The formation autophagosomes involves dynamic rearrangement membrane which two ubiquitin-like modifications (the conjugation Apg12p and modification soluble form MAP-LC3 to membrane-bound form) are essential. In yeast, Apg10p an E2-like enzyme essential conjugation. isolated mouse APG10 gene product interacts with mammalian dependent on Apg7p (E1-like enzyme), facilitates interaction...
Although volume reductions in the grey matter have been previously observed individuals with an at-risk mental state (ARMS) for psychosis, features of white integrity and their correlation psychiatric symptoms remain unclear.Forty-six ARMS subjects were examined using magnetic resonance imaging (MRI) to acquire diffusion tensor (DTI); also evaluated Scale Prodromal Symptoms at baseline 52 weeks. Sixteen healthy controls underwent MRI scanning. The DTI results longitudinally analyzed a...
The prevalence of comorbid social anxiety disorder among patients with schizophrenia is currently attracting attention, and symptoms are reportedly associated various clinical features. However, the contribution to functioning quality life (QOL) over time remains obscure. aim this study was examine impact changes in on QOL outpatients schizophrenia. Of 207 who were eligible at baseline, 118 agreed completed a follow-up investigation least 1 year (695.8 days average) after baseline study....
Abstract Although widespread cortical thinning centered on the fronto-temporal regions in schizophrenia has been reported, findings at-risk mental state (ARMS) patients have inconsistent. In addition, it remains unclear whether abnormalities of thickness (CT) ARMS individuals, if present, are related to their functional decline irrespective future psychosis onset. this multicenter study Japan, T1-weighted magnetic resonance imaging was performed at baseline 107 individuals with ARMS, who...
Abstract Aim: To describe clinical practice and research activities for early psychiatric intervention in Japan, a country with huge number of beds history long‐stay, hospital‐based psychiatry. Methods: The characteristics, methods studies implementation at four leading institutions Japan are described. Results: Tokyo Youth Club (Tokyo), the Department Neuropsychiatry Toyama University Hospital (Toyama), S endai A t‐risk Mental State F irst E pisode (SAFE) service (Sendai), Il Bosco Toho...