A5089369193- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Psychosocial Factors Impacting Youth
- Schizophrenia research and treatment
- Diverse Approaches in Healthcare and Education Studies
- Obsessive-Compulsive Spectrum Disorders
- Advanced MRI Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Educational Systems and Policies
- Cerebrospinal fluid and hydrocephalus
- Autism Spectrum Disorder Research
- Alzheimer's disease research and treatments
- Youth Education and Societal Dynamics
- Neurosurgical Procedures and Complications
- Sociology and Education Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Intracranial Aneurysms: Treatment and Complications
- Head and Neck Cancer Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Amoebic Infections and Treatments
- Health, Environment, Cognitive Aging
- Energy and Environmental Systems
- Korean Peninsula Historical and Political Studies
- Spatial Neglect and Hemispheric Dysfunction
- Educational Research and Pedagogy
Seoul National University
2022-2024
Seoul National University Hospital
2023
New Generation University College
2023
Korea Advanced Institute of Science and Technology
2023
Yonsei University
2015-2021
Korea University
2019
Rush University Medical Center
2018
National Health Insurance Service Ilsan Hospital
2005-2015
National Health Insurance Service
2013-2015
Biogen (Switzerland)
2014
Abstract Machine learning approaches using structural magnetic resonance imaging (sMRI) can be informative for disease classification, although their ability to predict psychosis is largely unknown. We created a model with individuals at CHR who developed later (CHR-PS+) from healthy controls (HCs) that differentiate each other. also evaluated whether we could distinguish CHR-PS+ those did not develop (CHR-PS-) and uncertain follow-up status (CHR-UNK). T1-weighted brain MRI scans 1165...
Abstract Background Schizophrenia is associated with an increased risk of aggressive behaviour, which may partly be explained by illness-related changes in brain structure. However, previous studies have been limited group-level analyses, small and selective samples inpatients long time lags between exposure outcome. Methods This cross-sectional study pooled data from 20 sites participating the international ENIGMA-Schizophrenia Working Group. Sites acquired T1-weighted diffusion-weighted...
Importance In vivo imaging studies of reactive astrocytes are crucial for understanding the pathophysiology schizophrenia because play a critical role in glutamate imbalance and neuroinflammation. Objective To investigate patients with associated positive symptoms using monoamine oxidase B (MAO-B)–binding fluorine 18 ([ F])–labeled THK5351 positron emission tomography (PET). Design, Setting, Participants this case-control study, data were collected from October 1, 2021, to January 31, 2023,...
To characterize the epidemiology of primary laryngeal lymphoma and to determine prognostic factors affecting survival in patients with this disease.A retrospective cohort study using Surveillance, Epidemiology, End Results (SEER) database, including cases from 1973 2014.A population-based analysis was conducted more than 15 different geographic regions across United States. Patients were chosen based on a diagnosis site within larynx. Two hundred eligible inclusion criteria, characteristic...
Obsessive-compulsive disorder (OCD) is a heterogeneous condition characterized by distinct symptom subtypes, each with varying pathophysiologies and treatment responses. Recent research has highlighted the role of amygdala, brain region that central to emotion processing, in these variations. However, amygdala subregions functions not yet been fully elucidated. In this study, we aimed clarify biological mechanisms underlying OCD subtype heterogeneity investigating functional connectivity...
Changes in dopamine and fronto-striato-thalamic (FST) circuit functional connectivity are prominent schizophrenia. Dopamine is thought to underlie changes, but experimental evidence for this hypothesis lacking. Previous studies examined the association some of connections using positron emission tomography (PET) MRI (fMRI); however, PET has disadvantages scanning patients, such as invasiveness. Excessive induces neuromelanin (NM) accumulation, NM-MRI suggested a noninvasive proxy measure...
The lack of robust neuroanatomical markers psychosis risk has been traditionally attributed to heterogeneity. A complementary hypothesis is that variation in measures the majority individuals at may be nested within range observed healthy individuals.
Improving diagnostic accuracy of obsessive-compulsive disorder (OCD) using models brain imaging data is a key goal the field, but this objective challenging due to limited size and phenotypic depth clinical datasets. Leveraging diversity in large non-clinical datasets such as UK Biobank (UKBB), offers potential solution problem. Nevertheless, it remains unclear whether classification trained on populations will generalise individuals with OCD. This question also relevant for...
There have been conflicting reports on whether conventional verbal fluency measures can predict the prognosis of individuals at clinical high risk (CHR) for psychosis. We aimed to investigate task that represent semantic processing more directly than could be reliable predictors later remission in CHR individuals.We recruited and healthy controls participate a baseline assessment. identified clusters within responses based cosine similarity between consecutive words, calculated from word...
Isolated middle cerebral artery (MCA) stenosis in young patients with no other medical condition may be a unique pathologic entity benign long-term course. Generally, moyamoya disease shows progression of from internal (ICA) to intracranial vessel. A 26-year-old woman was admitted for choreic movements the right arm and leg. Brain magnetic resonance imaging showed stroke. Conventional angiography revealed 48% left M1 without ICA stenosis. Single photon emission computed tomography perfusion...
Patients with amnestic mild cognitive impairment (aMCI) are considered to have a high risk for Alzheimer dementia (AD). Even positive predictive values, however, cannot be guaranteed even by tests sensitivity and specificity when disease prevalence is low. If we regard the clinical criteria aMCI as test predicting due AD, value of will low definition in young patients (age below 65 years) because AD this age group. To hypothesis, compared CSF biomarkers between old years or older) groups...
Lee Mi-rok’ The Yalu River Flows is a Korean autobiographical growth novel. It becomes text that can find out how the identity of Korea and Koreans projected. Ethnic plays an important role in society culture. In this study, we explore problem Mi-rok’s flows. addition, I would like to learn about psychological state who have come into contact with Western We objectify ourselves today define them historically. For Germans, Mi-rok played mediating between West Korea. During Japanese colonial...
Youth culture has diversity and complexity that cannot be accessed with simple logic. From the 17th 18th centuries, perceptions of children adolescents began to change. literary works are classified as genres can directly reflect characteristics times. literature evaluated reflecting values historical era. German youth been developed by contributing 'discovery youth'. Hesse criticizes school education social system suppresses in “Under Wheel”. Interpreting nature through a new approach.
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis can exhibit a wide spectrum of clinical features, including psychiatric symptoms, movement disorders, and autonomic dysfunction.1-4 We report an unusual presentation anti-NMDAR in 31-year-old woman. The patient had no preceding flu-like symptom history psychotic episode or drug before onset. She experienced visual auditory hallucinations 1 year admission. Her were about strange old woman who forced her to repeat what she said....
Abstract Changes in dopamine and fronto-striato-thalamic (FST) circuit functional connectivity are prominent schizophrenia. Dopamine is thought to underlie changes, but experimental evidence for this hypothesis lacking. Previous studies examined the association some of connections using positron emission tomography (PET) MRI (fMRI); however, PET has disadvantages scanning patients, such as invasiveness. Excessive induces neuromelanin (NM) accumulation, NM-MRI suggested a noninvasive proxy...
We present the eleventh case of benign pleomorphic fibroma arising on scalp in a young Korean woman. Histopathologically these lesions were characterized by polypoid or dome-shaped cutaneous fibrous mass with sparse cellularity but striking nuclear atypia and rare mitotic figures. They all showed clinical behavior, despite histopathological findings.