A5068223700- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Alzheimer's disease research and treatments
- Cardiovascular Health and Disease Prevention
- Neurological Disease Mechanisms and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Antiplatelet Therapy and Cardiovascular Diseases
- Neurosurgical Procedures and Complications
- Neurological Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Pharmacy and Medical Practices
- Advanced Neuroimaging Techniques and Applications
- Stroke Rehabilitation and Recovery
- Health and Wellbeing Research
- Parkinson's Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Botulinum Toxin and Related Neurological Disorders
- Health disparities and outcomes
- Cerebrospinal fluid and hydrocephalus
- Intracerebral and Subarachnoid Hemorrhage Research
- Nutritional Studies and Diet
- Ion Channels and Receptors
- Diverse Approaches in Healthcare and Education Studies
National Health Insurance Service Ilsan Hospital
2015-2024
National Health Insurance Service
2014-2023
Eulji University
2005-2023
Yonsei University
2010-2022
Universiti Sains Malaysia
2021
Yeouido St. Mary's Hospital
2018-2020
Catholic University of Korea
2018-2020
Myongji Hospital
2018
Hanyang University
2018
Kyung Hee University Hospital at Gangdong
2018
Background and Purpose— Cilostazol, a phosphodiesterase inhibitor, has been reported to reduce restenosis rate after coronary angioplasty stenting. This study was performed investigate the effect of cilostazol on progression intracranial arterial stenosis (IAS). Methods— We randomized 135 patients with acute symptomatic in M1 segment middle cerebral artery or basilar either 200 mg per day placebo for 6 months. Aspirin 100 also given all patients. Patients potential embolic sources heart...
<b><i>Background:</i></b> We examined the efficacy of group-based cognitive intervention (GCI) and home-based (HCI) in amnestic mild impairment (aMCI) effects on serum brain-derived neurotrophic factor (BDNF). <b><i>Methods:</i></b> In this randomized rater-blinded trial, 293 patients with aMCI from 18 nationwide hospitals were randomized: 96 to GCI group, 98 HCI group 99 control group. For 12 weeks, subjects receiving participated twice per...
Abstract Background The South Korean government has been actively involved in plans to combat dementia, implementing a series of national strategies and since 2008. In July 2014, eligibility for mandatory long-term care insurance (LTCI) was extended people with dementia enabling access appropriate including the cognitive function training program home nursing service. This study aimed investigate changes treatment patterns Alzheimer’s disease (AD) between 2011 June 2017 which spanned 2014...
<b><i>Background:</i></b> This study is intended to evaluate the propensities of cilostazol reduce pulsatility index (PI) in patients with acute lacunar infarction using serial transcranial Doppler (TCD) examinations. <b><i>Methods:</i></b> In a multicenter, randomized, double-blind, placebo-controlled trial, were randomly assigned receive either placebo or 100 mg twice day as well aspirin day. The primary outcomes changes middle cerebral...
Background and Purpose— An effective stroke code system that can expedite rapid thrombolytic treatment requires notification/communication an organized team approach. We developed a program based on the computerized physician order entry (CPOE) investigated whether implementation of this CPOE-based is useful for reducing time from arrival at emergency departments (ED) to evaluation steps initiation in various hospital settings. Methods— The was implemented by 10 hospitals. Time intervals ED...
The off-the-line primary side regulation flyback LED lamp driver is proposed based on forward voltage tracking (VFT) and duty variation (DVT) methods, which satisfy good line/load regulation, high power factor TRIAC dimming possibility. This paper introduces that four derivative types (TYPE-I to IV) are possible implement using supply voltage, MOSFET drain cycle signal with the of sensing circuits basis VFT DVT concepts. load regulations TYPE-I IV show 0.89%, 0.51%, 0.43% 0.56% [A/V],...
Background The prevalence and incidence of Parkinson`s disease (PD) are important for supporting the better comprehension aspects helping public health planning. Our aim is to evaluate in South Korea between 2004 2013. Methods This retrospective, nationwide, longitudinal population-based study used National Health Insurance Service-National Sample Cohort Database define patients with PD from 2013 based on having Korean Classification Diseases code G20, which were assigned by neurologists,...
Background Although disclosing the predictors of different behavioral and psychological symptoms dementia (BPSD) is first step in developing person-centered interventions, current understanding limited, as it considers BPSD a homogenous construct. This fails to account for their heterogeneity hinders development interventions that address underlying causes target subsyndromes. Moreover, influence proximal factors—circadian rhythm–related factors (ie, sleep activity levels) physical...
Background: Optimal antithrombotic regimens to prevent recurrent stroke in patients with ischemic due atrial fibrillation (AF) and atherosclerotic large-vessel stenosis remain unknown. Aims: This study aimed evaluate the effect of multiple therapies on outcomes at 1 year after two or more causes. Methods: We identified 862 AF large artery atherosclerosis from linked data. These were categorized into three groups according discharge: (1) antiplatelets, (2) oral anticoagulants (OAC), (3)...
<b><i>Background:</i></b> The Effect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index the Transcranial Doppler (ECLIPse) study showed a significant decrease transcranial (TCD) pulsatility index (PI) with cilostazol treatment at 90 days after acute lacunar infarction. aim present was to perform subgroup analysis ECLIPse order explore effect infarction based cerebral white matter hyperintensities (WMH) volume....
Background and Purpose: Previous studies have reported conflicting results about the prevalence of seizures in Alzheimer's disease (AD).There are few epidemiological on this topic Asia.Thus, objective study was to examine demographic clinical characteristics as well incidence for AD patients compared non-AD a prospective, longitudinal, community-based cohort with long follow-up.Methods: Data were collected from National Health Insurance Service-National Elderly Cohort (NHIS-elderly) Database...
Previous studies have suggested a decreased cancer risk among patients with Alzheimer's disease (AD). There remains lack of data on the specific types and factors for developing in AD. We evaluated association between AD risk, we examined cancer.A population-based longitudinal study was conducted using National Health Insurance Service-Senior cohort 2002-2013. A total 4,408 were included study, as 19,150 matched controls. Potential associations analyzed Cox proportional hazard...
Objectives The present study examined self‐reports and informant reports of cognitive function discrepancies between the two reporting methods in healthy controls (HC), subjective decline (SCD), mild impairment (MCI), very Alzheimer disease (AD) using three questionnaires. Methods included a total 300 individuals (mean age: 74.4 ± 5.7 y), including 130 HC, 70 SCD, 51 MCI, 49 AD patients. Self‐ratings ratings were assessed Korean Dementia Screening Questionnaire‐Cognition (KDSQ‐C), AD8,...
Transient receptor potential cation channel, subfamily V, member 1 (TRPV1, also known as vanilloid 1) is a that detects capsaicin, pungent component of chili peppers, and noxious heat. Although its function in the primary nociceptor pain well established, whether TRPV1 expressed brain still under debate. In this study, responses cortical neurons were investigated. Here, we report capsaicin induces caspase-3-dependent programmed cell death, which coincides with increased production nitric...
Background: Korea has a periodic general health check-up program that uses the Korean Dementia Screening Questionnaire-Cognition (KDSQ-C) as cognitive dysfunction screening tool.The Alzheimer Disease 8 (AD8) and Subjective Memory Complaints Questionnaire (SMCQ) are also used in clinical practice.We compared diagnostic ability of these questionnaires for impairment when completed by participants their caregivers.Hence, we aimed to evaluate whether SMCQ or AD8 is superior KDSQ-C can be its...
To compare the efficacy and safety of antiplatelet agents for secondary prevention ischemic stroke based on cytochrome P450 2C19 (CYP2C19) polymorphisms.This study was a prospective, multicenter, randomized, parallel-group, open-label, blind genotype trial. First time non-cardiogenic patients were enrolled screened within 30 days. Participants randomized to receive either triflusal or clopidogrel prevention. The primary outcome from randomization first recurrent hemorrhagic stroke.The...
Subcortical vascular dementia (SVaD) is one of the most common dementias, after Alzheimer's disease (AD) dementia. Few survival analyses in SVaD patients have been reported.The dates and causes death 146 725 AD were included. We used Cox proportional hazards model to compare between explore possible factors related patients.The median time onset (109 months) was shorter than that recorded for (152 months). The cause stroke (47.1%). Factors associated with late onset, male sex, worse baseline...
Alzheimer’s disease (AD) has a strong propensity to run in families. However, the known risk genes excluding APOE are not clinically useful. In various complex diseases, gene studies have targeted rare alleles for unsolved heritability. Our study aims elucidate previously unknown AD by targeting alleles. We used data from five publicly available genetic Disease Neuroimaging Initiative (ADNI) and database of Genotypes Phenotypes (dbGaP). A total 4,171 cases 9,358 controls were included. The...
ABSTRACT BACKGROUND AND PURPOSE The Effect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index Transcranial Doppler (ECLIPse) study showed a significant decrease transcranial pulsatility index (PI) with cilostazol treatment after 90 days acute lacunar infarction. aim this analysis was to perform subgroup the ECLIPse explore relationship between serum uric acid (UA) and volume white matter hyperintensities (WMH) patients METHODS multicenter, randomized, double‐blind,...