A5100705067- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Blood Pressure and Hypertension Studies
- Cardiac Imaging and Diagnostics
- Dementia and Cognitive Impairment Research
- Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Cerebral Venous Sinus Thrombosis
- Cerebrospinal fluid and hydrocephalus
- Moyamoya disease diagnosis and treatment
- Tracheal and airway disorders
- Retinal and Optic Conditions
- Vasculitis and related conditions
- Cardiovascular and Diving-Related Complications
- Pharmacological Effects and Toxicity Studies
- Cerebral Palsy and Movement Disorders
- Obstructive Sleep Apnea Research
Boramae Medical Center
2016-2025
Samsung SDS (South Korea)
2024
Seoul National University
2015-2024
Seoul Metropolitan Government
2015-2024
Samsung (South Korea)
2024
New Generation University College
2021-2023
Eulji University
2005-2023
National University College
2018-2023
Seoul National University Hospital
2003-2022
Samsung Medical Center
2022
Background and Purpose- Although there are a variety of risk factors predictive models for stroke-associated pneumonia (SAP), more objective easily accessible markers still needed. In this study, we evaluated the relationship between neutrophil-to-lymphocyte ratio (NLR) SAP in patients with acute ischemic stroke. Methods- We assessed 1317 consecutive was defined according to modified Centers Disease Control Prevention criteria. The severity rated using scores from Pneumonia Severity Index,...
Background and Purpose— Cilostazol, a phosphodiesterase inhibitor, has been reported to reduce restenosis rate after coronary angioplasty stenting. This study was performed investigate the effect of cilostazol on progression intracranial arterial stenosis (IAS). Methods— We randomized 135 patients with acute symptomatic in M1 segment middle cerebral artery or basilar either 200 mg per day placebo for 6 months. Aspirin 100 also given all patients. Patients potential embolic sources heart...
Background and Purpose— An optimal strategy for management of symptomatic intracranial atherosclerotic stenosis (ICAS) has not yet been established. We compared the efficacy 2 combinations antiplatelets, aspirin plus cilostazol (cilostazol group) verus clopidogrel (clopidogrel group), on progression ICAS, which is known to be associated with clinical stroke recurrence. Methods— In this investigator-initiated double-blind trial, 457 patients acute in M1 segment middle cerebral artery or...
Abstract Background Delayed arrival at hospital is one of the major obstacles in enhancing rate thrombolysis therapy patients with acute ischemic stroke. Our study aimed to investigate factors associated prehospital delay after stroke Korea. Methods A prospective, multicenter was conducted 14 tertiary hospitals Korea from March 2009 July 2009. We interviewed 500 consecutive who arrived within 48 hours. Univariate and multivariate analyses were performed evaluate influencing delay. Results...
Abstract Background The South Korean government has been actively involved in plans to combat dementia, implementing a series of national strategies and since 2008. In July 2014, eligibility for mandatory long-term care insurance (LTCI) was extended people with dementia enabling access appropriate including the cognitive function training program home nursing service. This study aimed investigate changes treatment patterns Alzheimer’s disease (AD) between 2011 June 2017 which spanned 2014...
<i>Background:</i> Aspirin is a proven antiplatelet agent in acute ischemic stroke, and there are no current guidelines for other treatments. We aimed to compare the efficacy safety of cilostazol with aspirin stroke. <i>Methods:</i> Patients measurable neurological deficits (NIHSS score ≤15) within 48 h onset were randomly assigned (200 mg/day) or (300 90 days. The primary endpoint was modified Rankin Scale (mRS) 0–2 at Cardiovascular events, bleeding complications,...
In patients with acute ischemic stroke caused by large artery atherosclerosis, clopidogrel plus aspirin versus alone might be more effective to prevent recurrent cerebral ischemia. However, there is no clear evidence.In this multicenter, double-blind, placebo-controlled trial, we randomized 358 of presumed atherosclerosis origin within 48 hours onset (75 mg/d without loading dose) (300-mg followed 100 mg/d) or for 30 days. The primary outcome was new symptomatic asymptomatic lesion on...
Patients with single subcortical infarctions (SSIs) have relatively a favorable prognosis, but they often experience early neurological deterioration (END). In this study, we compared the predictors for END in patients SSI according to location of lesion.We included consecutive SSIs within 72 hours symptom onset presenting between 2010 and 2016. was defined as an increase ≥2 total National Institutes Health Stroke Scale (NIHSS) score or ≥1 motor NIHSS first admission. Along analysis all SSI,...
Abstract The triglyceride-glucose (TyG) index has been associated with various metabolic, cardiovascular, and cerebrovascular diseases. We evaluated the association between TyG early recurrent ischemic lesions (ERILs) in patients acute stroke (AIS). included consecutive diagnosed AIS 2010 2016. ERILs were defined as new diffusion-weighted imaging outside initial symptomatic lesion area. was calculated using following formula: log scale of fasting triglyceride × glucose/2. A total 176...
Abstract Background Initial D-dimer level is a well-known prognostic parameter in patients with acute ischemic stroke (AIS). However, there have been no studies on the clinical significance of follow-up levels. In this study, we evaluated association between initial and levels early neurological deterioration (END) AIS. Methods We included consecutive AIS who had positive test (> 0.55 mg/L) March 2021 November 2022. The was performed 7th day after hospitalization discharge if discharged...
Introduction: Patients with single subcortical infarction (SSI) have relatively favorable prognosis, but they often experience early neurological deterioration (END) in a clinical course. Endothelial shear stress (ESS) applied to the vascular wall may also be one of causes. Hypothesis: We would like analyze association between ESS and occurrence END SSI patients. Methods: included consecutive patients within 72 hours symptom onset 2010 2020. was defined as an increase ≥ 2 total NIHSS score...
Background and Purpose— Predictors of progression intracranial atherosclerotic stenosis have not been clearly identified. We investigated whether poststroke changes in lipid profiles would affect the prognosis symptomatic stenosis. Methods— This is a substudy Trial cilOstazol Symptomatic Stenosis 2 (TOSS-2). From 10 centers we enrolled 230 subjects with acute M1 segment middle cerebral artery or basilar artery. At baseline 7 months after stroke, underwent MR angiogram assessment...
<h3>Importance</h3> The risk of early recurrent stroke after transient ischemic attack (TIA) may be modifiable by optimal treatment. Although ABCD<sup>2</sup>scores, diffusion-weighted imaging lesions, and large artery stenosis are well known to predict recurrence, other neuroimaging parameters, such as cerebral microbleeds (CMBs), have not been explored in patients with TIA. <h3>Objective</h3> To determine the rate TIA its predictors. <h3>Design, Setting, Participants</h3> In this...
Cerebral small vessel disease (SVD) commonly coexists with large artery atherosclerosis (LAA).We evaluate the effect of SVD on stroke recurrence in patients for ischemic LAA.We consecutively collected first-ever who were classified as LAA mechanism between Jan 2010 and Dec 2013. Univariate multivariate Cox analyses performed to association 2-year demographic, clinical, radiological factors. To impact its components recurrent stroke, we used Kaplan-Meier analysis. was defined presence severe...
<i>Background:</i> Basilar artery (BA) dolichoectasia (dilatative arteriopathy) (BAD) causes arterial elongation and enlargement with subsequent hemodynamic changes leading to thrombosis, microembolization brainstem compression. Little is known about the association between BAD pattern of pontine infarct in patients without BA stenosis. <i>Methods:</i> We studied isolated infarcts recruited from a stroke registry. The infarction were divided into 2 groups based on...
Background Advances in mobile health (mHealth) have enabled systematic and continuous management of patients with chronic diseases. Objective We developed a smartphone-based mHealth system aimed to evaluate its effects on behavior risk factor control stroke patients. Methods With multifaceted aftercare that included exercise, medication, educational materials, we performed 12-week single-arm intervention among eligible poststroke the clinic from September December 2016. The consisted (1)...
Stroke-associated pneumonia (SAP) is common in patients with acute ischemic stroke, and several risk factors have been reported. However, the relationship between underlying leukoaraiosis (LA) SAP has not addressed. We collected consecutive stroke within 24 h of symptom onset. was defined as lower respiratory tract infection first 7 days after onset, according to modified Centers for Disease Control Prevention criteria. LA graded using Fazekas scale both periventricular subcortical areas....
Background Increased arterial resistance is a potential pathological mechanism of cerebral small vessel disease (cSVD). Aim In this study, we aimed to investigate the association between pulsatility index (PI) representing and subtypes cSVD in patients with lacunar stroke. Methods We included consecutive stroke 2010 2013. White matter hyperintensity (WMH) volume was rated using semi-automated quantitative methods. Additionally, presence old infarct (OLI), microbleed (CMB), or enlarged...
Reduced cerebrovascular compliance is the major mechanism of cerebral small vessel disease (SVD). Obstructive sleep apnea (OSA) also promotes SVD development, but underlying was not elucidated. We investigated association among OSA, compliance, and parameters. This study retrospectively included individuals ≥ 50 years age, underwent overnight polysomnographic (PSG) for evaluation performed MRI transcranial Doppler (TCD) within 12 months interval without a neurological event between...
Abstract Previous studies have rarely investigated the role of non-vitamin K oral anticoagulants (NOAC) and warfarin in secondary prevention ischemic stroke patients with nonvalvular atrial fibrillation (NVAF). In this study, we compared effectiveness safety NOAC for Korean NVAF. Based on National Health Insurance Service Database, study included 21,064 anticoagulants-naïve acute NVAF between July 2015 June 2019. The main outcomes stroke, systemic embolism, major bleeding, death. During...