A5101878114- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Intracerebral and Subarachnoid Hemorrhage Research
- RNA Interference and Gene Delivery
- Traumatic Brain Injury and Neurovascular Disturbances
- Parkinson's Disease Mechanisms and Treatments
- Neurological Disorders and Treatments
- Advanced Drug Delivery Systems
- Intracranial Aneurysms: Treatment and Complications
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- 3D Printing in Biomedical Research
- Advanced Neuroimaging Techniques and Applications
- Ophthalmology and Eye Disorders
- Cardiovascular Health and Disease Prevention
- Peripheral Artery Disease Management
- Advanced MRI Techniques and Applications
- Cerebral Venous Sinus Thrombosis
- Myasthenia Gravis and Thymoma
- Peripheral Neuropathies and Disorders
- Neurosurgical Procedures and Complications
Chonnam National University Hospital
2014-2023
Cleveland Clinic
2017-2021
University of Toronto
2021
Animal and Plant Quarantine Agency
2020
Inje University Ilsan Paik Hospital
2016-2019
Creative Commons
2019
Seoul National University
2017-2018
The Neurological Institute
2018
Dongguk University Ilsan Hospital
2014-2017
Seoul National University Bundang Hospital
2015-2017
Leukoaraiosis or white matter hyperintensities are frequently observed on magnetic resonance imaging of stroke patients. We investigated how hyperintensity volumes affect outcomes, generally and by subtype. In total, 5035 acute ischaemic patients were enrolled. Strokes classified as large artery atherosclerosis, small vessel occlusion, cardioembolism. White stratified into quintiles. Mean age (± standard deviation) was 66.3 ± 12.8, 59.6% male. Median (interquartile range) modified Rankin...
There are limited data on the utilization of diagnostics and variation treatments at national level in acute stroke care. Clinical Research Center for Stroke – 5th division registry aimed to describe statistics quality care Korea implement indicators. was established April 2008 covers pretreatment demographics, medical severity measures, diagnostic evaluation, hyperacute revascularization, in-hospital management, discharge disposition, indicators, long-term functional outcomes. Consecutive...
Background Untreated acute mild stroke patients have substantial 90-day disability rates and worse outcomes than those who are treated with thrombolysis. There is little information regarding which will benefit from We sought to investigate factors that associated early neurological deterioration (END) poor prognosis in stroke. Methods This was a retrospective study of consecutively registered (NIHSS ≤3) at our tertiary center between October 2008 December 2011. END defined as an increase...
African swine fever, a fatal haemorrhagic disease of swine, was confirmed in domestic pigs for the first time South Korea September 2019. The causative virus belonged to p72 genotype II and had an additional tandem repeat sequence intergenic region (IGR) between I73R I329L.
Background and Purpose— We compared baseline characteristics outcomes at 3 months between patients with minor anterior circulation infarction (ACI) versus posterior (PCI), including the influence of large vessel disease on outcomes. Methods— This study is an analysis a prospective multicenter registry database in South Korea. Eligibility criteria were ischemic stroke admitted within 7 days onset, lesions either or circulation, National Institutes Health Stroke Scale score ≤4 baseline....
This study aimed to investigate whether pulse pressure (PP) obtained during the acute stage of ischemic stroke can be used as a predictor for future major vascular events.Using multicenter prospective registry database, patients who were hospitalized within 48 hours onset enrolled in this study. We analyzed blood (BP) data measured first 3 days from onset. Primary and secondary outcomes time composite recurrence, myocardial infarction, all-cause death, respectively.Of 9840 patients, 4.3%...
A number of authors have proposed retrograde arterial embolism as the responsible mechanism for filler-induced blindness. However, no previous human study has substantiated this mechanism. The aim was to investigate pathophysiology blindness using a fresh cadaver perfusion technique. head model that simulates both physiologic blood pressure and flow rate carotid artery, ophthalmic supratrochlear artery used. common cannulated internal jugular vein exposed open venous drainage. plasma-based...
Most patients with cerebral infarction die of brain edema because the breakdown blood-brain barrier (BBB) in ischemic tissue. Caveolins (a group proteins) are key modulators vascular permeability; however, a direct role caveolin-1 (Cav-1) regulation BBB permeability during injury has yet to be identified.Cav-1 expression was measured by immunoblotting after photothrombotic ischemia. A functional Cav-1 and ischemia investigated genetic manipulation (gene disruption re-expression) protein...
Cerebral vascular territories are of key clinical importance in patients with stroke, but available maps highly variable and based on prior studies small sample sizes.To update improve the state knowledge supratentorial supply to brain by using natural experiment large artery infarcts map out anatomy anterior, middle, posterior cerebral (ACA, MCA, PCA) territories.In this cross-sectional study, digital were generated diffusion-weighted magnetic resonance imaging (MRI) 1160 acute (<1-week)...
We aimed to generate rigorous graphical and statistical reference data based on volumetric measurements for assessing the relative severity of white matter hyperintensities (WMHs) in patients with stroke.We prospectively mapped WMHs from 2699 first-ever ischemic stroke (mean age=66.8±13.0 years) enrolled consecutively 11 nationwide centers, patient (fluid-attenuated-inversion-recovery) MRIs onto a standard brain template set. Using multivariable analyses, we assessed impact major...
In patients with acute ischemic stroke caused by large artery atherosclerosis, clopidogrel plus aspirin versus alone might be more effective to prevent recurrent cerebral ischemia. However, there is no clear evidence.In this multicenter, double-blind, placebo-controlled trial, we randomized 358 of presumed atherosclerosis origin within 48 hours onset (75 mg/d without loading dose) (300-mg followed 100 mg/d) or for 30 days. The primary outcome was new symptomatic asymptomatic lesion on...
The antioxidant properties of alpha-lipoic acid (aLA) correlate with its ability to promote neuroproliferation. However, there have been no comprehensive studies examining the neurorestorative effects aLA administration after onset ischemia. middle cerebral artery (MCA) adult rats was occluded for 2 hours and then reperfused. (20 mg/kg) administered in 71 animals (aLA group) through left external jugular vein immediately reperfusion. An equivalent volume vehicle (control group). Functional...
Background and Purpose— Randomized trials comparing the use of multimodal magnetic resonance imaging (MRI) to computed tomography (CT)/ CT angiography (CTA) for selecting candidates endovascular therapy (EVT) have not been reported. This study aimed elucidate whether MRI-based selection EVT is safe effective within after a 6-hour time window compared with conventional CTA-based selection. Methods— Data from prospective, nationwide, multicenter stroke registry were analyzed. Workflow...
Objective: The aim of this study was to evaluate a novel holographic craniofacial surgical planning application and its implementation throughout the operative stages facial transplantation by performing critical analysis comparative utility, cost, limitations MR 3D printing. Summary Background Data: Face is highly complex form reconstruction requiring significant planning, knowledge patient-specific spatial relationships, time-sensitive decision making. Computer-aided modeling has improved...
Background Although ethnic or cultural differences affect prevalence of cardiovascular risk factors, limited information is available about the age- and gender-stratified factors in Asian stroke population. Aims hypothesis We assessed gender- age-stratified prevalences major Korean patients, assumed that gender are attenuated by adjustment with lifestyle factors. Methods Using nationwide hospital-based registry, we identified 9417 ischemic patients admitted between April 2008 January 2011....
Background Patients presenting with minor ischemic stroke frequently have early neurological deterioration (END) and poor final outcome. The optimal management of patients END has not been determined. Objective To investigate rescue IA therapy (IAT) when acute develop END. Methods This was a retrospective study consecutively registered ‘END’ defined as an increase in National Institutes Health Stroke Scale (NIHSS) scores by 1 or more points (or development new symptoms) ‘ΔEND−NIHSS’...
Background One third of patients presenting with initially mild strokes have unfavorable outcomes, and the efficacy intravenous thrombolysis ( IVT ) in this population has not been proven. This study aimed to evaluate comparative effectiveness standard care versus without stroke patients. Methods Results Using a multicenter registry database, we identified acute ischemic who presented within 4.5 hours symptom onset had initial National Institutes Health Stroke Scale scores ≤5. Multivariable...