A5106615687- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Advanced Neuroimaging Techniques and Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Insect and Pesticide Research
- Advanced Materials and Mechanics
- Exercise and Physiological Responses
- Aerosol Filtration and Electrostatic Precipitation
- Food Allergy and Anaphylaxis Research
- Neuroscience and Neuropharmacology Research
- Healthcare and Venom Research
- Airway Management and Intubation Techniques
- Biosensors and Analytical Detection
- Protease and Inhibitor Mechanisms
- Photoreceptor and optogenetics research
- Tracheal and airway disorders
- Connexins and lens biology
- Intracranial Aneurysms: Treatment and Complications
- Regulation of Appetite and Obesity
- Gold and Silver Nanoparticles Synthesis and Applications
- Hydrogels: synthesis, properties, applications
- Micro and Nano Robotics
- Advanced Sensor and Energy Harvesting Materials
Samsung Medical Center
2024
Pohang University of Science and Technology
2021
Dongguk University
2011-2020
Dongguk University Ilsan Hospital
2014-2019
Korea University
2018
Korea Institute of Science and Technology
2011-2017
Center for Systems Biology
2011-2017
Harvard University
2011-2017
Massachusetts General Hospital
2011-2017
Seoul National University
2017
Computed tomography (CT) is the current standard for time-critical decision-making in stroke patients, informing decisions on thrombolytic therapy with tissue plasminogen activator (tPA), which has a narrow therapeutic index. We aimed to develop CT-based method directly visualize cerebrovascular thrombi and guide therapy. Glycol-chitosan-coated gold nanoparticles (GC-AuNPs) were synthesized conjugated fibrin-targeting peptides, forming fib-GC-AuNP. This targeted imaging agent non-targeted...
Cerebral vascular territories are of key clinical importance in patients with stroke, but available maps highly variable and based on prior studies small sample sizes.To update improve the state knowledge supratentorial supply to brain by using natural experiment large artery infarcts map out anatomy anterior, middle, posterior cerebral (ACA, MCA, PCA) territories.In this cross-sectional study, digital were generated diffusion-weighted magnetic resonance imaging (MRI) 1160 acute (<1-week)...
Micro-computed tomography (mCT) offers high-resolution images, but it suffers from low contrast sensitivity and poor soft tissue contrast. We introduce a new mCT imaging technique with improved for the dynamic spatial temporal characterization of poststroke blood-brain barrier (BBB) dysfunction in small animals vivo.Transient middle cerebral artery occlusion was induced 1 hour 10- to 12-week-old C57BL/6 mice (n=35). At 4, 24, 48 hours after ischemic stroke, serial vivo performed 5 minutes...
High experimental variability in mouse embolic stroke models could mask the effects of treatments. We hypothesized that imaging thrombus directly would allow this to be controlled.We optically labeled thrombi with a near-infrared fluorescent (NIRF) probe C15 is covalently linked fibrin by factor-XIIIa. Labeled was injected into left distal internal carotid artery (ICA) C57/BL6 mice (n=47), near its bifurcation, and laser-Doppler cerebral-blood-flow (CBF) assessed for 30 minutes. NIRF done ex...
Quantitative imaging for the noninvasive assessment of thrombolysis is needed to advance basic and clinical thrombosis-related research tailor tissue-type plasminogen activator (tPA) treatment stroke patients. We quantified evolution cerebral thromboemboli using fibrin-targeted glycol chitosan-coated gold nanoparticles microcomputed tomography, with/without tPA therapy.We injected thrombi into distal internal carotid artery in mice (n=50). Fifty-five minutes later, we nanoparticles, 5 after...
We present a durable superhydrophobic poly(vinylidene fluoride) (PVDF)-based nanofibrous membrane to achieve high-performance air filters with reusability. demonstrate that the additional assembly of silica nanoparticles on an electrospun PVDF and subsequent low-surface-energy treatment enables nonwetting various probing liquids exhibit low roll-off angle (∼15°) even for 1 μL water artificial saliva droplets. This allows fine dust particles adsorbed modified be easily removed by washing...
Characterization of responsive hydrogels and their enhancement with novel moieties have improved our understanding functional materials. Hydrogels coupled inorganic nanoparticles been sought for types materials, but the efficient routes formation responsivity complexed materials remain further investigation. Here, we report that poly(N-isopropylacrylamide-co-acrylic acid) (pNIPAm-co-AAc) hydrogel microparticles (microgels) are tunable by varying composition co-monomer crosslinker as well...
Results: A total of 291 patients were included. The common cause bee species was vespid (24.6%) in venom anaphylaxis, fol- lowed by honeybee and (8.8%), apitherapy (7.7%), (2.0%), although the causative com- monly unknown (56.9%). severity anaphylaxis mostly mild-moderate (72.9%), clinical manifestations in- cluded cutaneous (80.6%), cardiovascular (39.2%), respiratory (38.1%), gastrointestinal (13.1%) symptoms. Portable epinephrine auto-injectors prescribed to 12.1% patients. Subject...
Direct thrombus imaging visualizes the root cause of thromboembolic infarction. Being able to image directly allows far better investigation stroke than relying on indirect measurements, and will be a potent robust vascular research tool. We use an optical approach that labels thrombi with molecular marker — Cy5.5 near-infrared fluorescent (NIRF) probe is covalently linked fibrin strands by fibrin-crosslinking enzymatic action activated coagulation factor XIIIa during process clot...
Abstract We recently generated a high-resolution supratentorial vascular topographic atlas using diffusion-weighed MRI in population of large artery infarcts. These MRI-based maps are not easily applicable to CT scans, because the standard-reference-lines for axial image orientation (i.e., anterior-posterior commissure line versus orbito-meatal line, respectively) ‘not parallel’ each other. Moreover, current, widely-used CT-based diagrams omit demarcation inter-territorial border-zones....
The aim of this study is to identify the principal circulating factors that modulate atheromatous matrix metalloproteinase (MMP) activity in response diet and exercise.Methods Results:Apolipoprotein-E knock-out (ApoE-/-) mice (n=56) with pre-existing plaque, fed either a Western (WD) or normal (ND), underwent 10 weeks treadmill exercise had no treatment. Atheromatous MMP was visualized using molecular imaging MMP-2/9 activatable near-infrared fluorescent (NIRF) probe. Exercise did not...
Pharmacokinetic (PK) evaluation of nanomaterials are crucial for further clinical development imaging nanomaterials. In spite huge advances in nanoparticle-based biomedical research, PK assessment typically requires substantial resources. Here, we show a simple, inexpensive, and yet precise analytical method applicable to the interrogation gold nanoparticles (AuNPs) body. We have developed UV–vis spectroscopic technique that utilizes mechanochemical treatments separate AuNPs from tissues...
Epiglottis abnormality is rare condition and can lead embarrassing intubation to anesthesiologists. Here, we reported a case of successful management in patient with unexpected hidden vocal cords due epiglottis adhesion the posterior wall laryngeal cavity.