A5100462885- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Liver Disease Diagnosis and Treatment
- Virology and Viral Diseases
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Ultrasound in Clinical Applications
- Face Recognition and Perception
- Animal Disease Management and Epidemiology
- EEG and Brain-Computer Interfaces
- Pulmonary Hypertension Research and Treatments
- Protease and Inhibitor Mechanisms
- Multiple Sclerosis Research Studies
- Sepsis Diagnosis and Treatment
- Infectious Encephalopathies and Encephalitis
- Adipokines, Inflammation, and Metabolic Diseases
- Respiratory Support and Mechanisms
- Cardiovascular Disease and Adiposity
- Traumatic Brain Injury and Neurovascular Disturbances
- Influenza Virus Research Studies
- Long-Term Effects of COVID-19
- Neural dynamics and brain function
- Stroke Rehabilitation and Recovery
- Atrial Fibrillation Management and Outcomes
University Hospital Cologne
2021-2023
University of Cologne
2023
Evangelisches Krankenhaus Alsterdorf
2022
Universität Hamburg
2022
University Medical Center Hamburg-Eppendorf
2022
Cornell University
2020
Asan Medical Center
2017
Center for Systems Biology
2017
Harvard University
2017
Massachusetts General Hospital
2017
Computed tomography (CT) is the current standard for time-critical decision-making in stroke patients, informing decisions on thrombolytic therapy with tissue plasminogen activator (tPA), which has a narrow therapeutic index. We aimed to develop CT-based method directly visualize cerebrovascular thrombi and guide therapy. Glycol-chitosan-coated gold nanoparticles (GC-AuNPs) were synthesized conjugated fibrin-targeting peptides, forming fib-GC-AuNP. This targeted imaging agent non-targeted...
Background and Purpose: One-fifth of ischemic strokes are embolic undetermined source (ESUS). Their theoretical causes can be classified as cardioembolic versus noncardioembolic. This distinction has important implications, but the categories’ proportions unknown. Methods: Using data from Cornell Acute Stroke Academic Registry, we trained a machine-learning algorithm to distinguish non-cardioembolic strokes, then applied ESUS cases determine predicted proportion with an occult source. A...
Abstract Since the outbreak of coronavirus disease 2019 (COVID-19), a growing number cases acute transverse myelitis associated with COVID-19 have been reported. Here, we present case patient who developed sensory ataxia after MR lesions suggestive for longitudinal and in splenium corpus callosum. The was successfully treated immunoadsorption.
Quantitative imaging for the noninvasive assessment of thrombolysis is needed to advance basic and clinical thrombosis-related research tailor tissue-type plasminogen activator (tPA) treatment stroke patients. We quantified evolution cerebral thromboemboli using fibrin-targeted glycol chitosan-coated gold nanoparticles microcomputed tomography, with/without tPA therapy.We injected thrombi into distal internal carotid artery in mice (n=50). Fifty-five minutes later, we nanoparticles, 5 after...
A Newcastle disease virus (NDV)-vectored vaccine expressing clade 2.3.4.4b H5 Hemagglutinin was developed and assessed for efficacy against H5N1 highly pathogenic avian influenza (HPAI) in specific pathogen-free (SPF) chickens, broilers, domestic ducks. In SPF the live recombinant NDV-vectored vaccine, rK148/22-H5, achieved complete survival HPAI NDV challenges significantly reduced viral shedding. Notably, rK148/22-H5 conferred good clinical protection broilers despite presence of...
The aim of this study is to identify the principal circulating factors that modulate atheromatous matrix metalloproteinase (MMP) activity in response diet and exercise.Methods Results:Apolipoprotein-E knock-out (ApoE-/-) mice (n=56) with pre-existing plaque, fed either a Western (WD) or normal (ND), underwent 10 weeks treadmill exercise had no treatment. Atheromatous MMP was visualized using molecular imaging MMP-2/9 activatable near-infrared fluorescent (NIRF) probe. Exercise did not...
Abstract Background To examine the pathological effect of a mesial temporal seizure onset zone (SOZ) on local and inter-regional response to faces in amygdala other structures lobe. Methods Intracranial EEG data was obtained from amygdala, hippocampus, fusiform gyrus parahippocampal nine patients with drug-refractory epilepsy during visual stimulation mosaics. We analyzed event-related potentials (ERP), gamma frequency power, phase-amplitude coupling phase-slope-index compared results...