We previously reported that Korean red ginseng (KRG) exerts an anti-inflammatory role through inhibiting caspase-11 non-canonical inflammasome in macrophages; however, the components responsible for remained unclear. This study explored activity of KRG saponin fraction (KRGSF) inflammasome-activated macrophages. KRGSF inhibited pyroptosis, pro-inflammatory cytokine secretion, and inflammatory mediator production J774A.1 cells. A mechanism revealed KRGSF-induced action was mediated via...

Immune checkpoint inhibitors (ICIs) are one of the main pillars cancer therapy. Since other studies such as clinical trial and retrospective study have limitations for detecting immune-related adverse events (irAEs) characterized by unpredictable onset, nonspecific symptoms wide spectrum, we aimed to identify incidence irAEs detect evaluate signals using real-world data. Cancer patients treated with anticancer medications were analyzed nationwide health insurance claims database South Korea...

Background: Radiographic examination is a widely used evaluation method in the orthopedic clinic. However, conventional radiography alone does not reflect dynamic changes between foot and ankle segments during gait. Multiple 3-dimensional multisegment models (3D MFMs) have been introduced to evaluate intersegmental motion of foot. In this study, we evaluated correlation static radiographic indices indices. Methods: One hundred twenty-five females were tested. Static radiographs full-leg...

Background: Total ankle replacement (TAR) and arthrodesis (AA) are usually performed for severe arthritis. We compared postoperative foot segmental motion during gait in patients treated with TAR AA. Methods: Gait analysis was 17 7 undergoing AA, respectively. Subjects were evaluated using a 3-dimensional multisegmental model 15 markers. Temporal parameters calculated. The maximum minimum values the differences hallux, forefoot, hindfoot, arch 3 planes (sagittal, coronal, transverse) between...

Vitiligo is a pigmentary disorder induced by loss of melanocytes. In addition to replacement pure melanocytes, cocultures melanocytes with keratinocytes have been used improve the repigmentation outcome in vitiligo treatment. We previously identified vitro studies, that adipose-derived stem cells (ADSCs) could be potential substitute for this study, efficacy pigmentation including durability grafted and short-term safety was examined nude mouse Sprague-Dawley rat after grafting primary...

Abstract The objective of this study was to find the effect hallux valgus (HV) deformity on inter‐segmental motion foot using an MFM with a 15‐marker set (DuPont Foot Model, DuFM) in comparison age and sex controlled healthy adults. Fifty‐eight female symptomatic HV patients 50 asymptomatic older volunteers were included study. According radiographic angle (HVA), population divided into severe (SHV, HVA ≥ 40°, n = 25), moderate (MHV, 20° ≤ < 47), control (CON, 36). MHV group (S‐MHV, 33)...

We report a case of lymphadenoma arising in the parotid gland. A 53-year-old female patient presented with mass Grossly, it was well-demarcated solid measuring 3 cm diameter. Microscopic examination revealed many cysts or duct-like structures background prominent lymphoid stroma, confirming diagnosis lymphadenoma. This particular thought to have arisen from an intraparotid lymph node. Lymphadenoma is rare benign neoplasm salivary gland partial resemblance other tumors, such as Warthin's...

Although accumulative evidence exists that support the applicability of multi-segmental foot models (MFMs) in evaluating motion various pathologic conditions, little is known effect aging on inter-segmental motion. The objective this study was to evaluate differences between older and younger adult healthy females during gait using a MFM with 15-marker set.One hundred symptom-free females, who had no radiographic osteoarthritis, were evaluated set. They divided into young (n = 50, 20-35...

The use of three-dimensional multi-segment foot models (3D MFMs) is increasing since they have superior ability to illustrate the effect and ankle pathologies on intersegmental motion compared single-segment model gait analysis. However, validation repeatability 3D MFMs important for their clinical use. Although many been validated in normal adults, research MFM children lacking. purpose this study validate intrasession, intersession, interrater an with a 15-marker set (DuPont model) healthy...

Distraction osteogenesis (DO) is a surgical technique in which new bone formation induced by gradual distraction of fracture callus after low-energy corticotomy, with careful preservation the soft tissue surrounding bone. 1) DO primarily used various difficult or intractable clinical conditions such as chronic osteomyelitis, 2) critical defect, 3) severe deformity, and leg length

Idiopathic hypertrophic pachymeningitis (IHP) is a rare disease, and it characterized by chronic progressive inflammatory fibrosis thickening of the dura mater with resultant compression spinal cord or neural structure without any identifiable cause. It can occur in intracranial alone as craniospinal form. The form rarer than cranial extremely rare. We report case IHP craniocervical junction involving both discuss diagnosis management disease.

Morphologic features and pathogenesis of arterial changes occurring in Buerger's disease (thromboangiitis obliterans) are still controversial. This study describes histopathologic medium sized arteries from patients with disease, particularly the internal elastic lamina relation to immunologic mechanism injury. Seventeen segments occluded (femoral or popliteal arteries) 17 were analyzed by histopathological immunohistochemical methods. The most characteristic total luminal obliteration,...

Measurements of multi-axial Ground Reaction Force (GRF) can provides quite useful information for monitoring abnormalities gait during Activities in Daily Living (ADL). Measuring GRF using ambulatory sensing systems is difficult due to the height sensor and number sensors used. Therefore, we developed a wireless system having low (12 mm) capability simultaneously lateral vertical only four optical sensors. The proposed biaxial force showed interference rate (less than 0.1 %) excellent...

Spontaneous spinal epidural hematoma (SSEH) is an uncommon disease, but it can lead to acute cord compression with disabling consequences. Identifiable reasons for spontaneous hemorrhage are vascular malformations and bleeding disorders. However, SSEH after taking herbal medicines has not been described yet. A 60-year-old female experienced sudden back pain combined numbness weakness in the lower limbs several hours no trauma, drug use, family history or any disease history. Her deep tendon...

Seedlessness is the most important characteristic of citrus and one its breeding purposes.Triploids are reliable way to secure seedlessness can be developed through crosses between tetraploids diploids or diploids.We evaluated characteristics seed formation recovery frequency triploids in interploid this study.Normal was highest (85.0%) 2x × 2x, followed by 4x 4x.Partially seeds were obtained at rate (35.3%) from with 0.7 per fruit, 0.2 0.1 respectively.The number undeveloped fruit 1.1, 1.0,...

Quercetin is a natural polyphenolic flavonoid widely found in plants, fruits, and vegetables, has been reported to play pharmacological roles numerous pathogenic conditions. The anti-inflammatory effects of quercetin various inflammatory conditions diseases have well-documented. However, its regulatory role noncanonical inflammasome activation not yet demonstrated. This study investigated the caspase-11 inflammasome-activated responses macrophages mouse model acute lethal sepsis. protected...

Three Gram-negative, aerobic and non-motile bacterial strains, BT552

This study sought to compare and analyze the characteristics of major components representative Chinese white tea domestically produced according production regions grades. The aim was provide basic data necessary for setting quality standards domestic production. Three grades from Fuding Yunnan in China, ‘WP’ Jeju Hadong Korea were analyzed. total amino acids individual acid contents higher teas than those Yunnan, tea, lowest ‘SM’. On other hand, polyphenol catechin Fuding, highest order...