A5021985299- Sarcoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Cardiac tumors and thrombi
- Bone Tumor Diagnosis and Treatments
- Orthopaedic implants and arthroplasty
- Lymphoma Diagnosis and Treatment
- Management of metastatic bone disease
- CAR-T cell therapy research
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Musculoskeletal synovial abnormalities and treatments
- Orthopedic Surgery and Rehabilitation
- Foot and Ankle Surgery
- Soft tissue tumor case studies
- Medical Imaging and Pathology Studies
- Advanced Radiotherapy Techniques
- Bone health and treatments
- Soft tissue tumors and treatment
- Reconstructive Surgery and Microvascular Techniques
- PARP inhibition in cancer therapy
- Ergonomics and Musculoskeletal Disorders
- Cancer Mechanisms and Therapy
- Anatomy and Medical Technology
- Inflammatory Biomarkers in Disease Prognosis
Asan Medical Center
2015-2024
Ulsan College
2015-2024
University of Ulsan
2015-2024
Seoul National University Hospital
2013-2016
Seoul National University
2015
Prognostic factors predictive of postmetastasis survival (PMS) in metastatic osteosarcoma are poorly understood. Our aims were to evaluate PMS patients with high-grade extremities, and identify prognostic related PMS.A retrospective review data for 126 was conducted. The study population consisted 70 men 56 women, a mean age 21 years (range: 4-75 years). follow-up period 37 months 1-245 months).The 5-year rate 31% median duration 22 months. In the multivariate analyses, no metastasectomy (P...
Comorbidity has not been examined as an independent prognostic factor in soft tissue sarcoma (STS). We the impact of comorbidity on oncologic outcome STS with adjustment for possible confounding factors.A retrospective review was performed 349 patients who had undergone surgery high-grade localized extremity at our institute. Conditions known to alter risk mortality, defined Charlson index, were classified comorbidities and 43 (12%) least one time surgery. The association outcomes local...
Systemic inflammation plays a critical role in cancer progression and oncologic outcomes patients. We investigated whether preoperative inflammatory biomarkers, including C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), neutrophil to lymphocyte ratio (NLR), could be surrogate biomarkers for predicting overall survival (OS) soft tissue sarcoma (STS) patients treated with surgery postoperative radiotherapy. A series of 99 who presented localized extremity STS were...
Preoperative transcatheter arterial embolization for hypervascular bone tumors is now widely accepted as a safe and effective procedure reducing intraoperative blood loss surgical morbidity. However, few studies have reported the use of preoperative nonspine metastases from hepatocellular carcinoma. The goal this study was to assess effect on clinical outcomes in surgery metastasis Seventy-five patients with carcinoma pelvis extremities were reviewed retrospectively. population consisted 62...
The relationship between arthritis or repetitive stress injuries (RSIs) in thumbs and rapidly increasing hours of smartphone usage is not fully elucidated. We evaluated axial joint reaction forces (AJRFs) thumb torques 19 healthy subjects performing typical tasks, which included tapping, tap game, swiping. measured force torque when a subject tapped swiped the panel analyzed motions each using surface markers motion capture systems. calculated AJRFs on inverse dynamics. results were then...
Abstract Background Limited data exist on the optimal postoperative surveillance protocol for high-grade soft tissue sarcoma, particularly regarding imaging modality and interval detecting local recurrence. This study aimed to assess benefit of short-term ultrasonography (USG) recurrence in patients with sarcoma. Methods Patients newly diagnosed sarcoma who underwent surgical resection between January 2010 June 2020 were included. Short-term USG was added follow-up as a tool alongside...
This study aimed to analyze the accuracy and errors associated with 3D-printed, patient-specific resection guides (3DP-PSRGs) used for bone tumour resection.We retrospectively reviewed 29 resections that 3DP-PSRGs based on 3D CT MRI. We evaluated amount margin relative preoperative plans. Guide-fitting guide distortion were intraoperatively one month postoperatively, respectively. categorized each of these error types into three grades (grade 1, < 1 mm; grade 2, 3 3, > mm) evaluate overall...
Non-spine bone metastasis accounts for approximately 20% of all skeletal metastases, but little data have been published that focused on to the pelvis and extremities as an initial manifestation cancer. We determined 1) clinicopathologic characteristics patients who presented with non-spine unknown primary malignancy, 2) process by which diagnosis cancer was made. retrospectively reviewed 84 site at time presentation. The study population consisted 56 men 28 women, a mean age 59.1 yr...
Abstract Tumor-induced osteomalacia (TIO) is an uncommon paraneoplastic syndrome presenting with sustained hypophosphatemia. Treatment of choice removal the tumor causing TIO, but identification culprit by routine imaging challenging. This study aimed to assess usefulness somatostatin receptor imaging, called 68 Ga-DOTATOC PET/CT, in management patients TIO. Twelve who were suspected having TIO underwent PET/CT. Lesion detectability and maximum standardized uptake value (SUV max ) determined...
Cortical atrophy is commonly observed after prosthetic reconstruction for bone sarcomas. However, relevant literature regarding this phenomenon in skeletally immature patients limited. Therefore, study, we evaluated the incidence and patterns of cortical atrophy. We then assessed its predisposing factors. Finally, analyzed whether was associated with poor prosthesis survival.We retrospectively reviewed 31 stems 19 osteosarcoma who were treated resection tumor surgery. measured thickness...
The presence of early postoperative fever after megaprosthesis replacement surgery is a concern for orthopedic oncologists due to the possibility infection. aims current study were determine incidences and patterns factors associated with its development clinical significance surgery. Seventy-one patients who had undergone reconstruction previously unoperated localized lower-extremity osteosarcoma reviewed. No patient evidence infection preoperatively. Mean age was 23.72±16.84 years (range,...
Abstract Background and Objectives The propeller flap is a reliable option for reconstruction after soft tissue sarcoma resection. However, some parts of the resection margin may move away from its original position during rotation thus can be excluded clinical target volume adjuvant radiotherapy. This study aimed to evaluate local recurrence with or free reconstruction. Methods Patients who underwent followed by radiotherapy at single institution were retrospectively reviewed. Results 1‐...
Treatment of bone lesions involved with the articular cartilage at talus is challenging. We report management lesions, particularly tumors and avascular necrosis (AVN), surface through treatment cement augmentation autologous graft.Eight benign three cases AVN were reviewed retrospectively a mean follow-up 56 months (range, 12-162). The age all patients was 36.1 years old 15-73) when assessed between February 2005 November 2021. Curettage tumorous necrotic resulted in significant defects...
Heat shock protein-90 (HSP90) remains an important cancer target because of its involvement in multiple oncogenic protein pathways and biologic processes. Although many HSP90 inhibitors have been tested the treatment KRAS-mutant non-small cell lung (NSCLC), most, including AUY922, failed due to toxic effects resistance generation, even though a modest efficacy has observed for these drugs clinical trials. In our present study, we investigated novel mechanism AUY922 explore possible avenues...