A5062571740- Functional Brain Connectivity Studies
- Neuroscience, Education and Cognitive Function
- Memory and Neural Mechanisms
- Transcranial Magnetic Stimulation Studies
- Neural dynamics and brain function
- Optical Imaging and Spectroscopy Techniques
- Neural and Behavioral Psychology Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- EEG and Brain-Computer Interfaces
- Advanced Neuroimaging Techniques and Applications
University of Nottingham
2020-2024
Nottingham Biomedical Research Centre
2024
White matter hyperintensity (WMH), a key imaging biomarker for brain health, is common in the general population and has prognostic implications stroke. Using multicenter MRI dataset of 9,719 stroke patients plus UK Biobank (n = 36,210 low- high-risk controls), we employed Subtype Stage Inference (SuStaIn) modeling identified three distinct WMH progression subtypes: fronto-parietal (T1), radial (T2), temporo-occipital (T3). Longitudinal validation confirmed that this classification was...
Working memory (WM) is one of the fundamental cognitive functions associated with dorsolateral prefrontal cortex (DLPFC). However, neurochemical mechanisms WM, including dynamic changes in neurometabolites such as glutamate and GABA DLPFC, remain unclear. Here, we investigated WM-related changes, alongside hemodynamic responses using a combination functional magnetic resonance spectroscopy (fMRS) imaging (fMRI). During WM task, measured Glx (glutamate + glutamine) levels editing...
Transcranial magnetic stimulation (TMS) is an FDA-approved neuromodulation treatment for major depressive disorder (MDD), thought to work by altering dysfunctional brain connectivity pathways, or indirectly modulating the activity of subcortical regions. Clinical response TMS remains highly variable, highlighting need baseline predictors and understanding changes associated with response. This systematic review examined features, in clinical improvement following MDD. Forty-one studies met...
Working memory (WM) is one of the fundamental cognitive functions associated with dorsolateral prefrontal cortex (DLPFC). However, we still know little about neurochemical mechanisms WM in DLPFC. Here, investigated WM-related dynamic neurometabolite and hemodynamic responses We measured Glx (glutamate+glutamine) GABA alterations as well blood-oxygen-level-dependent (BOLD) signal changes during a task combining functional magnetic resonance spectroscopy imaging (fMRI). In DLPFC, found that...