A5037270738- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Lipoproteins and Cardiovascular Health
- Neurological Disease Mechanisms and Treatments
- Neurological Disorders and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Dementia and Cognitive Impairment Research
- Cerebral Venous Sinus Thrombosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Blood Pressure and Hypertension Studies
- Cardiac Imaging and Diagnostics
- Neurosurgical Procedures and Complications
- Cardiac Health and Mental Health
- Ophthalmology and Eye Disorders
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Genetic Neurodegenerative Diseases
Chonnam National University Hospital
2016-2025
Seoul National University
2024
Dongguk University
2024
Inje University Ilsan Paik Hospital
2024
Eulji University Hospital
2024
Hallym University
2024
University of Southern California
2024
Soonchunhyang University
2024
Chonnam National University
2013-2023
Dongguk University Ilsan Hospital
2020-2023
The importance of underlying atherosclerotic intracranial artery stenosis (ICAS) in hyperacute stroke patients who receive endovascular therapy remains unknown.To report and compare the outcomes multimodal with without ICAS.A total 172 consecutive acute were treated that was heavily weighted toward stent-based thrombectomy. Patients ICAS underwent emergent angioplasty or stenting. Data compared between ICAS. Revascularization defined as Thrombolysis Cerebral Infarction grade ≥2b. A favorable...
Background Despite the recent acceptance of thrombectomy as standard care in patients with acute anterior circulation stroke, benefits remain uncertain for basilar artery occlusion ( BAO ). This study aimed to evaluate effectiveness and safety identify predictors outcomes a large cohort . Methods Results included 212 consecutive who underwent either stent‐retriever or contact aspiration first‐line approach between January 2011 August 2017 at 3 stroke centers. Clinical radiologic data were...
Background Untreated acute mild stroke patients have substantial 90-day disability rates and worse outcomes than those who are treated with thrombolysis. There is little information regarding which will benefit from We sought to investigate factors that associated early neurological deterioration (END) poor prognosis in stroke. Methods This was a retrospective study of consecutively registered (NIHSS ≤3) at our tertiary center between October 2008 December 2011. END defined as an increase...
<h3>BACKGROUND AND PURPOSE:</h3> Prediction of underlying intracranial atherosclerotic stenosis before endovascular therapy might be helpful for appropriate therapeutic planning in patients with acute ischemic stroke. This study aimed to compare the characteristics and treatment outcomes basilar artery occlusion relative existence or nonexistence stenosis. <h3>MATERIALS METHODS:</h3> Sixty-two underwent multimodal therapy. All stent-retriever thrombectomy as a first-line Patients additional...
The optimal treatment strategy for patients with emergent large vessel occlusion (ELVO) due to underlying severe intracranial atherosclerotic stenosis (ICAS) is unclear. purpose of this study was compare outcomes from angioplasty or without stenting and intraarterial infusion a glycoprotein IIb/IIIa inhibitor in ELVO ICAS, investigate predictors outcome after endovascular therapy such patients.
<h3>Objective</h3> To improve epidemiologic knowledge of neurologic deterioration (ND) in patients with acute ischemic stroke (AIS). <h3>Methods</h3> In this prospective observational study, we captured ND prospectively 29,446 AIS admitted to 15 hospitals Korea within 7 days onset. was defined as an increase NIH Stroke Scale (NIHSS) score ≥2 (total), or ≥1 (motor consciousness), any new symptoms. Change incidence rate after onset, causes, factors associated ND, modified Rankin (mRS) at 3...
Background Preclinical data suggest circadian variation in ischemic stroke progression, with more active cell death and infarct growth rodent models inactive phase (daytime) than (nighttime) onset. We aimed to examine the association of onset time presenting severity, early neurological deterioration (END), long-term functional outcome human stroke. Methods findings In a Korean nationwide multicenter observational cohort study from May 2011 July 2020, we assessed effects on initial severity...
Subarachnoid hemorrhage (SAH) may appear on computerized tomography scans after mechanical thrombectomy for acute ischemic stroke. The incidence and prognosis of this observation remain unknown. We investigated the frequency clinical consequences SAH treating stroke with a multimodal approach heavily weighted toward Solitaire stent.Seventy-four consecutive patients underwent stent as first-line treatment. Nonenhanced were performed before, immediately after, 24 hours treatment to detect SAH....
Excessive accumulation of β-amyloid peptide (Aβ) is one the major mechanisms responsible for neuronal death in Alzheimer's disease.Flavonoids, primarily antioxidants, are a group polyphenolic compounds synthesized plant cells.The present study aimed to identify flavonoid that could inhibit Aβ-induced by examining effects various flavonoids on neurotoxicity Aβ fragment 25-35 (Aβ25-35) mouse cortical cultures.Aβ25-35 induced concentration-and exposure-time-dependent death.Neuronal 20 μM...
Brain derived neurotrophic factor (BDNF) has been shown to play an important role in poststroke recovery. BDNF secretion is influenced by genetic and epigenetic profiles. This study aimed investigate whether val66met polymorphism promoter methylation status were associated with outcomes at two weeks one year after stroke.A total of 286 patients evaluated the time admission stroke, 222 (78%) followed later order evaluate consequences stroke both acute chronic stages. Stroke dichotomised into...
Background and Purpose— We compared baseline characteristics outcomes at 3 months between patients with minor anterior circulation infarction (ACI) versus posterior (PCI), including the influence of large vessel disease on outcomes. Methods— This study is an analysis a prospective multicenter registry database in South Korea. Eligibility criteria were ischemic stroke admitted within 7 days onset, lesions either or circulation, National Institutes Health Stroke Scale score ≤4 baseline....
<h3>Importance</h3> In atrial fibrillation (AF)–related acute ischemic stroke, the optimal oral anticoagulation strategy remains unclear. <h3>Objective</h3> To test whether rivaroxaban or warfarin sodium is safer and more effective for preventing early recurrent stroke in patients with AF-related stroke. <h3>Design, Setting, Participants</h3> A randomized, multicenter, open-label, blinded end point evaluation, comparative phase 2 trial was conducted from April 28, 2014, to December 7, 2015,...
Predictors and impact of hemorrhagic transformation (HT) after thrombectomy remain to be elucidated.To investigate the independent predictors each infarction (HI) parenchymal hematoma (PH) in patients with acute stroke due intracranial large vessel occlusion (LVO).We retrospectively reviewed data from 400 LVO who underwent thrombectomy. Logistic regression analyses were performed determine HI PH on post-treatment CT scans. Associations between HT poor outcome (modified Rankin Scalescore ≥3)...
Most patients with cerebral infarction die of brain edema because the breakdown blood-brain barrier (BBB) in ischemic tissue. Caveolins (a group proteins) are key modulators vascular permeability; however, a direct role caveolin-1 (Cav-1) regulation BBB permeability during injury has yet to be identified.Cav-1 expression was measured by immunoblotting after photothrombotic ischemia. A functional Cav-1 and ischemia investigated genetic manipulation (gene disruption re-expression) protein...
This study aimed to investigate the effectiveness and safety of intravenous infusion tirofiban after emergent angioplasty with or without stenting in patients intracranial atherosclerotic stenosis-related large-vessel occlusion stroke.We performed a retrospective case series 98 who underwent thrombectomy followed by treat occlusion. Patients were divided into 2 groups: those received continuous for 12 hours procedure (intravenous group, n=30) did not receive postprocedural (control n=68)....
<h3>Background and Objectives</h3> Female patients tend to have greater disability worse long-term outcomes after stroke than male patients. To date, the biological basis of sex difference in ischemic remains unclear. We aimed 1) assess differences clinical manifestation acute 2) investigate whether disparity is due different infarct locations or impacts same location. <h3>Methods</h3> This MRI-based multicenter study included 6,464 consecutive with (<7-days) from 11-centers South-Korea...
Background Whether deep learning models using clinical data and brain imaging can predict the long-term risk of major adverse cerebro/cardiovascular events (MACE) after acute ischaemic stroke (AIS) at individual level has not yet been studied. Methods A total 8590 patients with AIS admitted within 5 days symptom onset were enrolled. The primary outcome was occurrence MACEs (a composite stroke, myocardial infarction or death) over 12 months. performance (DeepSurv Deep-Survival-Machines...
Objectives. Inflammatory cytokines are implicated in the pathophysiology of both stroke and depression, their production is influenced by transcriptional activity particular gene polymorphisms. We hypothesised that alleles related to higher pro-inflammatory and/or lower anti-inflammatory cytokine would be associated with post-stroke depression (PSD). Methods. In 276 cases, was diagnosed using DSM-IV, classified into major PSD (N = 29), all (major plus minor) 77), control 199) groups....
Background and Purpose Predictive factors associated with stent-retriever thrombectomy for patients acute anterior circulation stroke remain to be elucidated. This study aimed investigate clinical procedural predictive of good outcome mortality after in a large cohort stroke. Methods We analyzed data 335 treated thrombectomy. A was defined as modified Rankin Scale score 0 2 at 3 months. The associations between clinical, imaging, mortality, respectively, were evaluated using logistic...