A5103246622- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Phytochemicals and Antioxidant Activities
- Stroke Rehabilitation and Recovery
- Education and Learning Interventions
- Diverse Approaches in Healthcare and Education Studies
- Ginseng Biological Effects and Applications
- Nutrition and Health in Aging
- Dysphagia Assessment and Management
- Tracheal and airway disorders
- Essential Oils and Antimicrobial Activity
- Traditional Chinese Medicine Analysis
- Acute Ischemic Stroke Management
- Phytochemistry and Bioactive Compounds
- Asthma and respiratory diseases
- Frailty in Older Adults
- Psychosocial Factors Impacting Youth
- melanin and skin pigmentation
- Plant chemical constituents analysis
- Bioactive natural compounds
- Diabetes Treatment and Management
- Food Quality and Safety Studies
- Ginger and Zingiberaceae research
- Education, Safety, and Science Studies
- Neurological Disease Mechanisms and Treatments
Catholic Kwandong University
2019-2025
International St. Mary's Hospital
2019-2025
Hyundai Pharm (South Korea)
2022-2025
Korea Research Institute of Bioscience and Biotechnology
2015-2024
Chonnam National University
2023-2024
Sunchon National University
2022-2024
Bank of Korea
2023
Weatherford College
2020
Suwon Research Institute
2020
Yong In University
2018
The objective of this study was to investigate the quality life in stroke patients using a swallowing (SWAL-QOL) questionnaire. correlation between SWAL-QOL questionnaire outcome and videofluoroscopic dysphagia scale (VDS) scores also determined.This cross-sectional retrospectively conducted with 75 symptoms. Videofluoroscopic (VFSS) questionnaires were performed for all patients. These divided into an oral feeding group tube group. compared 2 groups. severity estimated by VDS according...
Abstract Cholinesterase (ChE) and monoamine oxidase (MAO) inhibitors have been attracted as candidate treatments for Alzheimer's disease (AD). Fifteen khellactone-type coumarins from the roots of Peucedanum japonicum Thunberg were tested acetylcholinesterase (AChE), butyrylcholinesterase (BChE), MAO inhibitory activities. Compound 3′-angeloyl-4′-(2-methylbutyryl)khellactone ( PJ13 ) most potently inhibited AChE (IC 50 = 9.28 µM), followed by 3′-isovaleryl-4′-(2-methylbutyroyl)khellactone...
Dysphagia is a common clinical condition characterized by difficulty in swallowing. It sub-classified into oropharyngeal dysphagia, which refers to problems the mouth and pharynx, esophageal body esophagogastric junction. can have significant negative impact one's physical health quality of life as its severity increases. Therefore, proper assessment management dysphagia are critical for improving swallowing function preventing complications. Thus guideline was developed provide...
Background Whether deep learning models using clinical data and brain imaging can predict the long-term risk of major adverse cerebro/cardiovascular events (MACE) after acute ischaemic stroke (AIS) at individual level has not yet been studied. Methods A total 8590 patients with AIS admitted within 5 days symptom onset were enrolled. The primary outcome was occurrence MACEs (a composite stroke, myocardial infarction or death) over 12 months. performance (DeepSurv Deep-Survival-Machines...
The recently defined type of cell death ferroptosis has garnered significant attention as a potential new approach to cancer treatment owing its more immunogenic nature when compared with apoptosis. Ferroptosis is characterized by the depletion glutathione (GSH)/glutathione peroxidase-4 (GPx4) and iron-dependent lipid peroxidation. Diplacone (DP), geranylated flavonoid compound found in Paulownia tomentosa fruit, been identified have anti-inflammatory anti-radical activity. In this study,...
In the medical field, use of 3-dimensional (3D) printing is increasing explosively and it especially widespread in clinical application fabricating orthosis. Advantages 3D-printed orthosis compared to conventional ones include its lower cost, easier modification, faster fabrication. The 3D-printing technique makes possible for physicians easily create individual-tailored products. Recently, many kinds through 3D have been studied used. knee orthosis, ankle-foot wrist hand foot orthotics are...
To investigate the utility of preoperative multiparametric magnetic resonance imaging (mpMRI)-based clinical-radiomic analysis combined with machine learning (ML) algorithms in predicting expression Ki-67 proliferative index and p53 tumor suppressor protein patients meningioma.This multicenter retrospective study included 483 93 from two centers. The was classified into high (Ki-67≥5%) low (Ki-67<5%)-expressed groups, positive (p53≥5%) negative (p53<5%)-expressed groups. Clinical...
ABSTRACT Introduction Physical activity and body fatness affect breast cancer development outcome. There is a tendency to reduce physical in the early stages of treatment, but exercise interventions are rarely implemented during this period. Objective This study aimed longitudinally assess patients with first year after surgery investigate factors associated inactivity. Design A retrospective cohort study. Setting university hospital. Participants We reviewed medical records who visited...
Abstract Poly (ADP-ribose) polymerase 1 (PARP1) inhibitors are the first successfully approved synthetic lethal cancer treatments targeting BRCA1/2-mutated breast and ovarian cancers. However, limited responsiveness among patients with BRCA1/2 mutations emergence of resistance to PARP highlight growing need for alternative drugs, either as monotherapy or in combination inhibitors. Ubiquitin-Specific Protease (USP1), a member deubiquitinating enzyme (DUB) family, plays crucial role DNA repair...
Abstract BRM and BRG (SMARCA2/4) are two mutually exclusive catalytic ATPase subunits of the BAF complexes. SMARCA4 is frequently mutated in multiple cancers, including about 10% non-small cell lung cancer (NSCLC). As a result, deficient becomes more dependent on its paralog, SMARCA2, for their survival. Consequently, selective inhibitor targeting SMARCA2 potentially effective therapeutic option SMARCA4-mutant cancers. We identified HD-10991 HD-11030 as inhibitors evaluated potency...
Abstract Among 276 herbal extracts, a methanol extract of Castanopsis cuspidata var. sieboldii stems was selected as an experimental source for novel acetylcholinesterase (AChE) inhibitors. Five compounds were isolated from the by activity-guided screening, and their inhibitory activities against butyrylcholinesterase (BChE), monoamine oxidases (MAOs), β-site amyloid precursor protein cleaving enzyme 1 (BACE-1) also evaluated. Of these compounds, 4′- O -(α- l -rhamnopyranosyl)-3,3′,4-tri-...
Allergic asthma is a major health burden on society as chronic respiratory disease characterized by inflammation and muscle tightening around the airways in response to inhaled allergens. Daphne kiusiana Miquel medicinal plant that can suppress allergic airway inflammation; however, its specific molecular mechanisms of action are unclear. In this study, we aimed elucidate which D. inhibits inflammation. We evaluated anti-inflammatory effects ethyl acetate (EA) fraction compound, daphnetin,...
(1) Background: Progression of chronic obstructive pulmonary disease (COPD) leads to irreversible lung damage and inflammatory responses; however, biomarker discovery for monitoring COPD progression remains challenging. (2) Methods: This study evaluated the metabolic mechanisms potential biomarkers through integrated analysis receiver operating characteristic (ROC) changes in lung, plasma, urine, morphological characteristics function a model PPE/LPS-induced exacerbation. (3) Results:...
Asthma is a chronic inflammatory lung disease that causes respiratory difficulties. Black ginseng extract (BGE) has preventative effects on diseases such as asthma. However, the pharmacological mechanisms behind anti-asthmatic activity of BGE remain unknown. To investigate mechanism BGE, phorbol 12-myristate 13-acetate plus ionomycin (PMA/Iono)-stimulated mouse EL4 cells and ovalbumin (OVA)-induced mice with allergic airway inflammation were used. Immune (eosinophils/macrophages),...
Nine lignans and two butanolides were isolated from the stem bark of Machilus thunbergii their structures identified as machilin A (1), licarin B (2), zuonin (3), macelignan (4), secoisolancifolide (5), isolancifolide (6), oleiferin C (7), meso-dihydroguaiaretic acid (8), (9), F (10), nectandrin (11) by spectroscopic means. These compounds assessed for abilities to activate a caspase-3 activity in human promyeloid leukemic HL-60 cells. The intracellular (9) increased approximately 3.04,...