A5047005390- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Blood Pressure and Hypertension Studies
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Health and Disease Prevention
- Neurological Disease Mechanisms and Treatments
- Lipoproteins and Cardiovascular Health
- Neurological Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cerebral Venous Sinus Thrombosis
- Peripheral Artery Disease Management
- Thin-Film Transistor Technologies
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Retinal and Optic Conditions
- Semiconductor materials and devices
- Moyamoya disease diagnosis and treatment
- Cardiovascular Health and Risk Factors
Seoul National University Bundang Hospital
2016-2025
Seoul National University
2013-2025
Eulji University
2010-2025
National University College
2007-2023
Dongguk University Ilsan Hospital
2011-2023
New Generation University College
2007-2021
Ulsan College
2010-2021
University of Ulsan
2010-2021
Asan Medical Center
2010-2021
Seoul National University Hospital
2005-2021
<h3>Importance</h3> There are inconsistencies in concept, criteria, practice, and documentation of brain death/death by neurologic criteria (BD/DNC) both internationally within countries. <h3>Objective</h3> To formulate a consensus statement recommendations on determination BD/DNC based review the literature expert opinion large multidisciplinary, international panel. <h3>Process</h3> Relevant professional societies were recruited to develop regarding BD/DNC. Literature searches Cochrane,...
The association between the location and mechanism of a stroke lesion remains unclear. A diffusion-weighted imaging study may help resolve this lack clarity.We studied consecutive series 2702 acute ischemic patients whose lesions were confirmed by who underwent thorough etiological investigation. vascular territory in which an was situated identified using standard anatomic maps dominant arterial territories. Stroke subtype based on Trial ORG 10172 Acute Treatment, or TOAST, classification....
Objective: To evaluate the impact of neurological and medical complications on 3‐month outcomes in acute ischaemic stroke patients. Methods: We prospectively investigated for all consecutive patients admitted within 7 days from onset four university hospitals during a 1‐year period. Baseline data were collected. Poor outcome was defined as modified Rankin Scale score 3–6. Results: A total 1 254 recruited: 264 (21.1%) 303 (24.2%) experienced one or more complications, respectively. The most...
In order to improve inter-rater reliability and minimize diagnosis of undetermined etiology for stroke subtype classification, using a registry, we developed implemented magnetic resonance imaging (MRI)-based algorithm acute ischemic classification (MAGIC).We enrolled patients who experienced an stroke, were hospitalized in the 14 participating centers within 7 days onset, had relevant lesions on MR-diffusion weighted (DWI). MAGIC was designed reflect recent advances thrombolytic therapy....
Background Despite the recent acceptance of thrombectomy as standard care in patients with acute anterior circulation stroke, benefits remain uncertain for basilar artery occlusion ( BAO ). This study aimed to evaluate effectiveness and safety identify predictors outcomes a large cohort . Methods Results included 212 consecutive who underwent either stent‐retriever or contact aspiration first‐line approach between January 2011 August 2017 at 3 stroke centers. Clinical radiologic data were...
Background and Purpose— An optimal strategy for management of symptomatic intracranial atherosclerotic stenosis (ICAS) has not yet been established. We compared the efficacy 2 combinations antiplatelets, aspirin plus cilostazol (cilostazol group) verus clopidogrel (clopidogrel group), on progression ICAS, which is known to be associated with clinical stroke recurrence. Methods— In this investigator-initiated double-blind trial, 457 patients acute in M1 segment middle cerebral artery or...
Abstract Background Delayed arrival at hospital is one of the major obstacles in enhancing rate thrombolysis therapy patients with acute ischemic stroke. Our study aimed to investigate factors associated prehospital delay after stroke Korea. Methods A prospective, multicenter was conducted 14 tertiary hospitals Korea from March 2009 July 2009. We interviewed 500 consecutive who arrived within 48 hours. Univariate and multivariate analyses were performed evaluate influencing delay. Results...
Early neurological deterioration (END) occurs in ≥20% of single small subcortical infarctions (SSSIs; axial diameter ≤20 mm the perforator territories) and deters functional recovery. Both microvasculopathies atherosclerosis have been proposed to independently contribute occurrence END SSSI cases. We hypothesized that SSSIs differs according pathological process.We collected data from 587 patients with within 48 hours onset a prospective stroke registry containing 4961 case records....
Leukoaraiosis or white matter hyperintensities are frequently observed on magnetic resonance imaging of stroke patients. We investigated how hyperintensity volumes affect outcomes, generally and by subtype. In total, 5035 acute ischaemic patients were enrolled. Strokes classified as large artery atherosclerosis, small vessel occlusion, cardioembolism. White stratified into quintiles. Mean age (± standard deviation) was 66.3 ± 12.8, 59.6% male. Median (interquartile range) modified Rankin...
<h3>Objectives:</h3> Asymptomatic hemorrhagic transformation (HT) is not associated with immediate deterioration of patients acute ischemic stroke. However, it unclear whether clinically innocuous respect to long-term outcome. The aim this study was determine the impact asymptomatic HT on 3-month <h3>Methods:</h3> A consecutive series 1,618 patients, hospitalized between January 2004 and August 2007 for stroke within 7 days from symptom onset were identified in a prospective registry...
There are limited data on the utilization of diagnostics and variation treatments at national level in acute stroke care. Clinical Research Center for Stroke – 5th division registry aimed to describe statistics quality care Korea implement indicators. was established April 2008 covers pretreatment demographics, medical severity measures, diagnostic evaluation, hyperacute revascularization, in-hospital management, discharge disposition, indicators, long-term functional outcomes. Consecutive...
Objectives: Early neurological deterioration (END) is a common condition associated with poor outcome after acute ischemic stroke. We studied association between blood pressure (BP) variability and development of END. Methods: In this retrospective observational study, we consecutive series patients hospitalized for stroke within 24 h onset. The primary interest was the END according to predefined criteria first 72 During period, mean, maximum (max), minimum (min) values SBP DBP were...
<h3>Objective</h3> To improve epidemiologic knowledge of neurologic deterioration (ND) in patients with acute ischemic stroke (AIS). <h3>Methods</h3> In this prospective observational study, we captured ND prospectively 29,446 AIS admitted to 15 hospitals Korea within 7 days onset. was defined as an increase NIH Stroke Scale (NIHSS) score ≥2 (total), or ≥1 (motor consciousness), any new symptoms. Change incidence rate after onset, causes, factors associated ND, modified Rankin (mRS) at 3...
Background Preclinical data suggest circadian variation in ischemic stroke progression, with more active cell death and infarct growth rodent models inactive phase (daytime) than (nighttime) onset. We aimed to examine the association of onset time presenting severity, early neurological deterioration (END), long-term functional outcome human stroke. Methods findings In a Korean nationwide multicenter observational cohort study from May 2011 July 2020, we assessed effects on initial severity...
Background and Purpose— Elevated blood pressure (BP) is commonly observed in acute ischemic stroke known to be associated with hemorrhagic transformation (HT). However, the effect of BP variability on development HT not well. Methods— A consecutive series patients stroke, who were hospitalized within 24 hours onset showed no initial gradient echo MRI, enrolled this study. measurements during first 72 obtained, each patient was described using various summary parameters: SD, maximum (max),...
<h3>Objectives:</h3> Acute cerebral infarction may coexist with hypertensive intracerebral hemorrhage (ICH) because lacunae and ICH share common risk factors small-vessel pathology. We sought to determine the frequency predictors of new ischemic lesions (NIL) on diffusion-weighted imaging (DWI), in patients acute ICH, investigate whether NIL predicts subsequent clinical cerebrovascular events. <h3>Methods:</h3> This prospective study enrolled 97 diagnosed within 3 days after onset. DWI...
<i>Background:</i> Standard selection criteria for thrombolysis typically exclude patients with acute ischemic stroke unclear onset. Multimodal MRI screening may be able to identify those a favorable benefit-risk ratio thrombolysis. We aimed evaluate the safety and efficacy of MRI-based in unclear-onset (UnCLOS). <i>Methods:</i> reviewed database registries from 3 medical centers Korea. Subjects received intravenous tissue plasminogen activator (tPA) or combined tPA...
Background and Purpose— We compared baseline characteristics outcomes at 3 months between patients with minor anterior circulation infarction (ACI) versus posterior (PCI), including the influence of large vessel disease on outcomes. Methods— This study is an analysis a prospective multicenter registry database in South Korea. Eligibility criteria were ischemic stroke admitted within 7 days onset, lesions either or circulation, National Institutes Health Stroke Scale score ≤4 baseline....
This study aimed to investigate whether pulse pressure (PP) obtained during the acute stage of ischemic stroke can be used as a predictor for future major vascular events.Using multicenter prospective registry database, patients who were hospitalized within 48 hours onset enrolled in this study. We analyzed blood (BP) data measured first 3 days from onset. Primary and secondary outcomes time composite recurrence, myocardial infarction, all-cause death, respectively.Of 9840 patients, 4.3%...
The characteristics of infarctions restricted to the dorsal medulla have received little attention. This study aimed define distinct clinical features medullary infarction. Of 172 patients with a diagnosis infarction at Seoul National University Bundang Hospital from 2003 2014, 18 isolated were subjected analyses and laboratory findings. All presented acute vestibular syndrome dizziness/vertigo imbalance. Almost all (17/18, 94%) showed signs involvements nuclei, nucleus prepositus...
Background and purpose The occurrence of stroke in cancer patients is caused by conventional vascular risk factors cancer‐specific mechanisms. However, cryptogenic with was considered to be more related hypercoagulability. In this study, we investigated the potential D‐dimer level serve as a predictor early neurologic deterioration ( END ) active cancer. Methods We recruited 109 within 72 h symptom onset. defined an increase ≥1 point motor National Institutes Health Stroke Scale NIHSS) score...