A5047872104- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Acute Ischemic Stroke Management
- Cardiac Arrest and Resuscitation
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury Research
- Intracranial Aneurysms: Treatment and Complications
- Trauma and Emergency Care Studies
- Stroke Rehabilitation and Recovery
- Long-Term Effects of COVID-19
- Organ Donation and Transplantation
- Palliative Care and End-of-Life Issues
- Venous Thromboembolism Diagnosis and Management
- Cerebrospinal fluid and hydrocephalus
- Trauma Management and Diagnosis
- Traumatic Ocular and Foreign Body Injuries
- Vascular Malformations Diagnosis and Treatment
- Cerebral Venous Sinus Thrombosis
- Peripheral Neuropathies and Disorders
- Family and Patient Care in Intensive Care Units
- Vascular Procedures and Complications
- Blood Coagulation and Thrombosis Mechanisms
- Epilepsy research and treatment
- Neurological disorders and treatments
- Child Abuse and Related Trauma
University of Chicago Medical Center
2004-2025
University of Chicago
2012-2024
Neurological Surgery
2021-2024
Christ University
2023
Hospital Italiano de Buenos Aires
2017-2023
University of Illinois Chicago
2020
Stanford University
2005
Stanford Medicine
2005
Washington University in St. Louis
2005
Helios Salud
2002
<h3>Importance</h3> There are inconsistencies in concept, criteria, practice, and documentation of brain death/death by neurologic criteria (BD/DNC) both internationally within countries. <h3>Objective</h3> To formulate a consensus statement recommendations on determination BD/DNC based review the literature expert opinion large multidisciplinary, international panel. <h3>Process</h3> Relevant professional societies were recruited to develop regarding BD/DNC. Literature searches Cochrane,...
Object Prophylactic use of antiepileptic drugs (AEDs) in patients admitted with aneurysmal subarachnoid hemorrhage (SAH) is common practice; however, the impact this treatment strategy on in-hospital complications and outcome has not been systematically studied. The goal study was twofold: first, to describe prescribing pattern for AEDs an international population; second, delineate SAH. Methods authors examined data collected 3552 SAH who were entered into four prospective, randomized,...
Early vasospasm (EVSP), defined here as arterial narrowing seen on diagnostic angiography within the first 48 hours of aneurysmal rupture, is a rarely reported and poorly phenomenon in patients with subarachnoid hemorrhage (SAH). The purpose this study was to characterize EVSP large database such patients.We analyzed relationship clinical characteristics, in-hospital complications, outcome at 3 months among 3478 entered into 4 prospective, randomized, double-blind, placebo-controlled trials...
Object In this study the authors analyzed relationship of intraventricular hemorrhage (IVH) to in-hospital complications and clinical outcome in a large population patients with aneurysmal subarachnoid (SAH). Methods Data from 3539 SAH were evaluated, these data obtained four prospective, randomized, double-blind, placebo-controlled trials tirilazad that had been conducted between 1991 1997. Clinical characteristics, complications, at 3 months post-SAH (Glasgow Outcome Scale score) regard...
To characterize the present state of brain death (BD) determination in actual practice relative to contemporary American Academy Neurology (AAN) guidelines.We reviewed charts all adult (16 years and older) BD organ donors during 2011 from 68 heterogeneous hospitals Midwest United States. Data were collected across 5 categories: guideline performance, preclinical testing, clinical examination, apnea use ancillary tests. Practice within categories overall adherence AAN guidelines assessed.Two...
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is associated with stroke. The role of sex on stroke outcome has not been investigated. To objective this paper to describe the characteristics a diverse cohort acute patients COVID-19 disease and determine outcome.This retrospective study SARS-CoV-2 admitted between March 15 May 15, 2020 one six participating comprehensive centers. Baseline characteristics, subtype, workup, treatment are presented as total number...
Objectives: Acute liver failure (ALF) produces cerebral dysfunction and edema, mediated in part by elevated ammonia concentrations, often leading to coma death. The pathophysiology of edema ALF is incompletely understood. In vitro models the effects have predominately consisted dissociated astrocyte cultures or acute brain slices. We describe a stable long-term culture model incorporating both neural glial elements three-dimensional tissue structure offering significant advantages study...
Nyquist, Paul MD; Jichici, Draga Bautista, Cynthia RN; Burns, Joseph Chhangani, Sanjeev DeFilippis, Michele Goldenberg, Fernando D. Kim, Keri MSN, PharmD; Liu-DeRyke, Xi Mack, William Meyer, Kim MSN Author Information
Civilian penetrating brain injury (PBI) is associated with high mortality. However, scant literature available to guide neurocritical care monitoring and management of PBI.To examine the association intracranial pressure (ICP) mortality, intensive unit (ICU) length stay (LOS), dispositional outcomes in patients severe PBI.This comparative effectiveness research study analyzed data from Trauma Quality Improvement Program National Data Bank US January 1, 2017, December 31, 2019. Patients PBI...
Traumatic brain injury (TBI) is a global health challenge; however, penetrating (PBI) remains under-represented in evidence-based knowledge and research efforts. This study utilized data from the Trauma Quality Improvement Program (TQIP) of National Data Bank (NTDB) to investigate outcomes PBI as compared with clinical-severity-matched non-penetrating or blunt TBI. A total 1765 patients were 1:1 propensity score-matched for clinical severity TBI patients. The intent was self-inflicted 34.1%...
To introduce the UChicago PBI Imaging score, a novel characterization of imaging features using head computed tomography (HCT) in patients with gunshot wounds to (GSWH) resulting penetrating brain injury (PBI) and quantify association mortality. We retrospectively collected analyzed data from 230 GSWH admitted our Level 1 trauma center between May 1, 2018, October 31, 2023. HCT images obtained on hospital arrival were evaluated for predefined by two blinded readers arbitrated, when needed,...
Acute disseminated encephalomyelitis (ADEM) varies widely in symptoms and severity. Some cases are associated with massive life-threatening cerebral edema refractory to conventional medical management.A 51-year-old woman ADEM who developed severe brain swelling herniation despite aggressive management is described.A decompressive hemicraniectomy durotomy led rapid improvement an excellent outcome.This case report reinforces the place of this procedure armamentarium treatment options for...
Cancer immunotherapy with checkpoint inhibitors may result in neuromuscular immune-related adverse reactions, including Guillain-Barré syndrome (GBS)-like disease. On the other hand, inhibitor therapy exacerbation of underlying autoimmune diseases such as myasthenia gravis and multiple sclerosis. We present a patient who developed severe fatal relapse postvaccination GBS after he was treated nivolumab, monoclonal antibody directed to programmed death-1 (PD-1), during treatment-related...
<h3>Background</h3> Bickerstaff brainstem encephalitis (BBE) is a rare inflammatory, demyelinating disease that generally has good prognosis. <h3>Objective</h3> To describe the course of patient with severe BBE and multiple medical complications. <h3>Design</h3> Case report. <h3>Setting</h3> Academic center. <h3>Patient</h3> An 81-year-old woman who fully recovered. The had transient very frequent episodes dysfunction during recovery phase. <h3>Main Outcome Measures</h3> Clinical biochemical...
1Division of Neurocritical Care, Department Neurology, University Chicago Medical Center, Chicago, IL. 2Division Surgery (Neurosurgery), The authors have disclosed that they do not any potential conflicts interest. For information regarding this article, E-mail: [email protected]
Few studies have focused on the impact of racial differences in demographics, clinical characteristics, acute complications, and outcomes patients with aneurysmal subarachnoid hemorrhage (SAH). The purpose this study was to examine issue.The authors evaluated prospectively collected data 1711 adult SAH who were entered into two randomized, double-blind, placebo-controlled trials conducted at neurosurgical centers North America between 1991 1997. Admission treatment modalities, in-hospital...