Jae Guk Kim
A5102991352- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Stroke Rehabilitation and Recovery
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood Pressure and Hypertension Studies
- Lipoproteins and Cardiovascular Health
- Heart Rate Variability and Autonomic Control
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- S100 Proteins and Annexins
- Cardiovascular Health and Disease Prevention
- Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Cardiac Imaging and Diagnostics
- Peripheral Artery Disease Management
- Heart rate and cardiovascular health
- Cardiac Arrhythmias and Treatments
- Climate Change and Health Impacts
- Cerebrovascular and genetic disorders
- Health Systems, Economic Evaluations, Quality of Life
- Neurological diseases and metabolism
- Eicosanoids and Hypertension Pharmacology
Eulji University Hospital
2016-2025
Eulji University
2016-2025
National University College
2020-2023
Seoul National University Bundang Hospital
2015-2023
Boramae Medical Center
2023
Seoul National University
2023
Inje University Busan Paik Hospital
2023
Dongguk University Ilsan Hospital
2020-2023
Hallym University Sacred Heart Hospital
2023
Chonnam National University Hospital
2015-2020
Despite the great socioeconomic burden of stroke, there have been few reports stroke statistics in Korea. In this scenario, Epidemiologic Research Council Korean Stroke Society launched "Stroke Statistics Korea" project, aimed at writing a contemporary, comprehensive, and representative report on epidemiology This contains general prevalence behavioral vascular risk factors, characteristics, pre-hospital system care, hospital management, quality outcomes. report, we analyzed most up-to-date...
<h3>Objective</h3> To improve epidemiologic knowledge of neurologic deterioration (ND) in patients with acute ischemic stroke (AIS). <h3>Methods</h3> In this prospective observational study, we captured ND prospectively 29,446 AIS admitted to 15 hospitals Korea within 7 days onset. was defined as an increase NIH Stroke Scale (NIHSS) score ≥2 (total), or ≥1 (motor consciousness), any new symptoms. Change incidence rate after onset, causes, factors associated ND, modified Rankin (mRS) at 3...
Background Preclinical data suggest circadian variation in ischemic stroke progression, with more active cell death and infarct growth rodent models inactive phase (daytime) than (nighttime) onset. We aimed to examine the association of onset time presenting severity, early neurological deterioration (END), long-term functional outcome human stroke. Methods findings In a Korean nationwide multicenter observational cohort study from May 2011 July 2020, we assessed effects on initial severity...
Background and Purpose— We compared baseline characteristics outcomes at 3 months between patients with minor anterior circulation infarction (ACI) versus posterior (PCI), including the influence of large vessel disease on outcomes. Methods— This study is an analysis a prospective multicenter registry database in South Korea. Eligibility criteria were ischemic stroke admitted within 7 days onset, lesions either or circulation, National Institutes Health Stroke Scale score ≤4 baseline....
Background and Purpose— The aim of the study was to assessed impact short-term exposure air pollution on ischemic stroke subtype, while focusing caused via cardioembolism. Methods— From a nationwide, multicenter, prospective, registry database, 13 535 patients with acute hospitalized 12 participating centers were enrolled in this study. Data hourly concentrations particulate matter <10 μm, nitrogen dioxide (NO 2 ), sulfur (SO ozone (O 3 carbon monoxide (CO) collected from 181 nationwide...
<h3>Background and Objectives</h3> Female patients tend to have greater disability worse long-term outcomes after stroke than male patients. To date, the biological basis of sex difference in ischemic remains unclear. We aimed 1) assess differences clinical manifestation acute 2) investigate whether disparity is due different infarct locations or impacts same location. <h3>Methods</h3> This MRI-based multicenter study included 6,464 consecutive with (<7-days) from 11-centers South-Korea...
Futile reperfusion (poor functional status despite successful reperfusion) was observed in up to 67% of patients enrolled recent endovascular treatment (EVT) clinical trials. We investigated the impact baseline stroke severity on both futile and therapeutic benefit EVT. Using a prospective multicenter registry, we identified consecutive ischemic with anterior circulation large artery occlusion, who were reperfused successfully by EVT (Thrombolysis Cerebral Infarction grade 2b–3). The rate...
<h3>Objective</h3> To define the role and risks associated with white matter hyperintensity (WMH) load in a stroke population respect to recurrent mortality after ischemic stroke. <h3>Methods</h3> A total of 7,101 patients at network university hospitals presenting strokes were followed up for 1 year. Multivariable Cox proportional hazards model competing risk analysis used examine independent association between quartiles WMH recurrence <h3>Results</h3> Overall year was 6.7%/y, divided...
Background and Purpose- There is a paucity of information about the role resting heart rate in prediction outcome events patients with ischemic stroke atrial fibrillation. We aimed to investigate relationships between level variability acute period recurrence mortality after Methods- Acute who had fibrillation were hospitalized within 48 hours onset identified from multicenter prospective registry database. The was divided into early (within 24 hospitalization) late (72 7 days onset) stages,...
Background and Purpose— Randomized trials comparing the use of multimodal magnetic resonance imaging (MRI) to computed tomography (CT)/ CT angiography (CTA) for selecting candidates endovascular therapy (EVT) have not been reported. This study aimed elucidate whether MRI-based selection EVT is safe effective within after a 6-hour time window compared with conventional CTA-based selection. Methods— Data from prospective, nationwide, multicenter stroke registry were analyzed. Workflow...
Background and Purpose— Blood pressure dynamics in patients with acute ischemic stroke may serve as an important modifiable prognostic factor. Methods— A total of 8376 were studied from a prospective multicenter registry. Patients eligible if they had been admitted within 24 hours symptom onset ≥5 systolic blood (SBP) measurements during the first hospitalization. SBP trajectory groups identified using TRAJ procedure SAS software delta-Bayesian Information Criterion prespecified modeling...
Nelonemdaz is a multitarget neuroprotectant that selectively blocks N-methyl-D-aspartate receptors and scavenges free radicals, as proven in preclinical ischemia-reperfusion studies. We aimed to evaluate the safety efficacy of nelonemdaz patients with acute ischemic stroke receiving endovascular reperfusion therapy.
Importance Nelonemdaz selectively antagonizes the 2B subunit of N -methyl- d -aspartate glutamate receptor and scavenges free radical species. Objective To evaluate whether nelonemdaz enhances clinical outcomes patients with acute ischemic stroke undergoing emergent reperfusion therapy. Design, Setting, Participants This multicenter double-blind placebo-controlled randomized phase 3 trial (December 25, 2021, to June 30, 2023, in South Korea) recruited who met following criteria: National...
Previous research on patients with acute ischemic stroke (AIS) has shown a 0.5% incidence of major gastrointestinal bleeding (GIB) requiring blood transfusion during hospitalization. The existing literature insufficiently explored the long-term in this population despite decremental impact GIB outcomes. We analyzed data from cohort AIS admitted to 14 hospitals as part nationwide multicenter prospective registry between 2011 and 2013. These were followed up for 6 years. occurrence events,...
Background Research specifically addressing the efficacy of rosuvastatin versus atorvastatin in patients with ischemic stroke is insufficient. Using a large registry, we investigated whether 2 commonly used statins, and atorvastatin, differ their effectiveness reducing risk vascular events acute stroke. Methods We analyzed data from nationwide registry South Korea between January 2011 April 2022. Patients within 7 days onset who were prescribed either or at discharge included. The primary...
Background This study aims to evaluate temporal trends of advanced treatments and related clinical outcomes ischemic stroke through a decade‐long trend analysis, using data from comprehensive, national, multicenter registry. We also seek identify areas in need improvement. Methods Results analysis involved patients with or transient attack registered prospectively the CRCS‐K‐NIH (Clinical Research Center for Stroke Korea–National Institute Health) registry between 2011 2020. examined risk...
Background Elevated heart rate in patients with acute ischemic stroke is associated increased risk of mortality. Beta‐blocker therapy well known to reduce rate. Methods and Results This study was a post hoc analysis maximum rates ≥100 bpm. use, assessed on the eighth day after index stroke, categorized as persistent or nonpersistent based usage up 39 months. The primary outcome composite recurrence, myocardial infarction, mortality within first year. Long‐term mortality, secondary outcome,...
Background We investigated whether the association between blood pressure (BP) management in patients with successful reperfusion following endovascular therapy (EVT) and functional outcomes is mediated by BP variability parameters. Methods Results This a post hoc analysis of OPTIMAL‐BP (Outcome Patients Treated With Intra‐Arterial Thrombectomy‐Optimal Blood Pressure Control) trial, conducted at 19 centers South Korea. The primary outcome was 90‐day outcome, assessed using modified Rankin...
Backgrounds and Aims: This study investigates the temporal patterns of occult cancer incidence among survivors acute ischemic stroke (AIS), with a focus on variations by underlying etiology. Patients Methods: We analyzed data from prospective, multicenter registry national claims database, identifying AIS patients hospitalized between 2011 2013. were categorized etiology into two groups: Unidentified Stroke Etiology (USE) Identified (ISE). estimated rates within both groups overall cohort....
Purpose: Hyperintense vessels (HV) observed on FLAIR MRI are thought to represent slow antegrade or retrograde flow in leptomeningeal vessels, which develop as collat-eral pathways response major intracranial artery stenosis occlusion. HV is commonly seen conditions like Moyamoya disease and symptomatic ICA/MCA steno-occlusion. The correlation between cerebral hemodynamics, well the effect of STA-MCA bypass surgery HV, remains poorly understood. This study aimed investigate relationship...
Background and Purpose— Patients with minor ischemic stroke or transient attack are at high risk of recurrent vascular events, which potentially disabling fatal. This study aimed to evaluate contemporary subsequent event after in Korea. Methods— high-risk admitted within 7 days symptom onset were identified from a Korean multicenter registry database. We estimated 3-month 1-year rates the primary outcome (composite recurrence, myocardial infarction, all-cause death), major death explored...
Background and Purpose— The association between family history of stroke recurrence remains unclear. Methods— Using a web-based multicenter registry database, information on in first-degree relatives was collected prospectively for acute ischemic patients who were hospitalized within 7 days onset. categorized as follows: type the affected relative(s) with (paternal, maternal, sibling, or 2 more) age relative’s onset (<50, 50–59, 60–69, ≥70 years). Stroke captured using predetermined...