A5101636186- Acute Ischemic Stroke Management
- Migraine and Headache Studies
- Cerebrovascular and Carotid Artery Diseases
- Sympathectomy and Hyperhidrosis Treatments
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Ophthalmology and Eye Disorders
- Trigeminal Neuralgia and Treatments
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Oral microbiology and periodontitis research
- Cardiac Imaging and Diagnostics
- Peripheral Artery Disease Management
- Dental Health and Care Utilization
- Antiplatelet Therapy and Cardiovascular Diseases
- Obstructive Sleep Apnea Research
- Lipoproteins and Cardiovascular Health
- Intracranial Aneurysms: Treatment and Complications
- Neuroscience of respiration and sleep
- Liver Disease Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Metabolomics and Mass Spectrometry Studies
- Cerebrovascular and genetic disorders
- Chronic Kidney Disease and Diabetes
Ewha Womans University
2014-2025
Daiichi-Sankyo (South Korea)
2021
Dong-A Pharmaceutical (South Korea)
2021
Ewha Womans University Medical Center
2015-2019
Baewha Women's University
2018
Yonsei University
2012-2017
CHA University
2013-2014
CHA Bundang Medical Center
2013-2014
University of Turku
2008
Despite the great socioeconomic burden of stroke, there have been few reports stroke statistics in Korea. In this scenario, Epidemiologic Research Council Korean Stroke Society launched "Stroke Statistics Korea" project, aimed at writing a contemporary, comprehensive, and representative report on epidemiology This contains general prevalence behavioral vascular risk factors, characteristics, pre-hospital system care, hospital management, quality outcomes. report, we analyzed most up-to-date...
Summary Increased red blood cell distribution width (RDW), which is a marker of anisocytosis, associated with mortality and cardiovascular events in the general population patients heart failure or coronary disease. We investigated whether RDW acute cerebral infarction predictive functional outcome mortality. A total 847 consecutive first-ever who presented to emergency department within seven days symptom onset were enrolled this study. association poor (modified Rankin Scale >2)...
Background Vestibular migraine (VM), the common term for recurrent vestibular symptoms with features, has been recognized in appendix criteria of third beta edition International Classification Headache Disorders (ICHD-3β). We applied VM a prospective, multicenter headache registry study. Methods Nine neurologists enrolled consecutive patients visiting outpatient clinics headache. The presenting disorder and additional diagnoses were classified according to ICHD-3β. rates diagnosed probable...
The recently developed total cerebral small-vessel disease (CSVD) score might appropriately reflect the burden or severity of CSVD. We investigated whether CSVD is associated with long-term outcomes during follow-up in patients acute ischemic stroke. In total, 1,096 consecutive stroke who underwent brain magnetic resonance imaging were enrolled. calculated for each patient after determining microbleeds (CMBs), high-grade white-matter hyperintensities (HWHs), perivascular spaces (HPVSs), and...
<h3>Objectives:</h3> We investigated the association of cerebral microbleeds (CMBs) with long-term mortality in patients nonvalvular atrial fibrillation (NVAF) according to burden and distribution CMBs. <h3>Methods:</h3> This was a retrospective, hospital-based, observational study. In total, 504 consecutive ischemic stroke NVAF who underwent brain T2-weighted, gradient-recalled echo MRI were included. Data for date causes death based on certificates from Korean National Statistical Office....
Objective To investigate suicidality related to cluster headache and factors associated with increased in patients. Methods In this multicenter study, 193 patients were recruited between September 2016 August 2018. Patients asked about their during attacks, specifically passive suicidal ideation, active suicide plan, attempt. Univariable multivariable logistic regression analyses performed evaluate the high ictal (sum of positive response ≥ 2). followed up when they between-bouts period....
Brachial-ankle pulse wave velocity (baPWV) has been proposed as a simple, noninvasive method for estimating arterial stiffness. Although high baPWV was predictive of cardiovascular mortality and morbidity among general population, its value in patients with acute stroke is unknown. We evaluated the prognostic 1765 who had admitted ischemic completed measurement during admission. Primary outcomes were all-cause vascular (death because heart diseases, cerebrovascular or diseases arteries,...
To study the effect of disease duration on clinical, neuropsychological and [18F]-deoxyglucose (FDG) PET findings in patients with mixed type multiple system atrophy (MSA), this included 16 controls 37 mixed-type MSA a shorter than 3-year history cerebellar or parkinsonian symptoms. We classified into three groups according to symptoms (Group I = ≤1 year; II 13–24 months; III 25–36 months). performed UPDRS, international cooperative ataxia rating scale (ICARS), test battery. compared FDG...
The identification of metabolic alterations in type 2 diabetes (T2D) is useful for elucidating the pathophysiology disease and classifying high-risk individuals. In this study, we prospectively examined associations between serum metabolites T2D risk a Korean community-based cohort (the Ansan-Ansung cohort). Data were obtained from 1,939 participants with available profiles without diabetes, cardiovascular disease, or cancer at baseline. acylcarnitine, amino acid, amine, phospholipid levels...
Higher serum alkaline phosphatase (ALP) and phosphate levels are associated with atherosclerotic disease an increased risk of cardiovascular events. However, the association ALP/phosphate cerebral atherosclerosis prognosis in patients acute stroke is not well known.In 1034 first-ever infarction, ALP were compared (1) (2) poor long-term functional outcomes as defined by modified Rankin Scale>2 at 3 months after onset.ALP atherosclerosis. higher a outcome (adjusted odds ratio per 1 SD, 1.25;...
Background Sleep disturbances are closely related to migraine. Nevertheless, information regarding the impact of short sleep duration and poor quality on clinical presentation migraine at population level is limited. Methods This study was a nationwide population-based survey adults aged 19–69 years. Headache frequency (attacks/month) intensity (visual analogue scale, 0–10) were documented. Short defined as average <6 h/day Pittsburgh Quality Index score >5, respectively. The...
The risk of vitamin D deficiency varies with the season. frequency in migraine patients and its association are unclear. We retrospectively evaluated first-visit between January 2016 May 2017, investigated demographics, season, subtypes, frequency, severity, impact migraine, psychological sleep variables, climate factors, levels. nonfasting serum 25-hydroxyvitamin concentration was measured to determine level, defined as a <20 ng/mL. In total, 157 aged 37.0±8.6 years (mean±standard...
Stroke patients are at high risk of developing pneumonia, which is major cause post-stroke mortality. Proton pump inhibitors and H2 receptor antagonists anti-ulcer drugs, may predispose to the development pneumonia by suppression gastric acid with bactericidal activity. Unlike proton antagonists, mucoprotective agents have gastroprotective effects no or less anti-acid property. We aimed investigate acid-suppressive medications (proton antagonists) on for using National Health Insurance...
Introduction: This study assessed the therapeutic effectiveness of a single-pill combination (SPC) olmesartan/amlodipine plus rosuvastatin for blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) in patients with hypertension dyslipidemia. Methods: Adult dyslipidemia who were decided to be treated drug eligible. The primary endpoint was proportion achieved BP, LDL-C both BP treatment goals at weeks 24-48. Secondary endpoints 24-48 included changes levels from baseline;...
The global burden of gout, a severe and painful arthralgia, is note expected to increase in the future. We aimed investigate association between triglyceride/high-density lipoprotein (TG/HDL) ratio, simple validated biomarker for insulin resistance, incidence gout longitudinal setting general population. Our study was conducted using National Health Insurance Service-Health Screening Cohort database Republic Korea (2002-2019). included 300,107 participants who had no previous history data...
The effects of blood pressure (BP) lowering in patients treated with intravenous tissue plasminogen activator (IV tPA) before endovascular thrombectomy (EVT) are unclear. This study aims to investigate whether intensive and conventional BP management affect outcomes differently, depending on IV tPA administration EVT. In this subgroup analysis the Outcome Patients Treated Intra-Arterial Thrombectomy-Optimal Blood Pressure Control (OPTIMAL-BP; ClinicalTrials.gov Identifier: NCT04205305)...
High LDL-cholesterol (LDL-C) is a well-known risk factor for coronary artery disease (CAD). PCSK9, HMGCR, NPC1L1, ACLY, and LDLR gene have been reported as lipid lowering drug genes related to LDL-C lowering. However relevant Asian studies were rare. We examined the causality between LDL-c target CAD using Korean Japanese data two sample Mendelian Randomization (MR) method. conducted two-sample MR analysis of (7 Single-nucleotide polymorphisms (SNP) in 6 SNPs 5 9 3 LDLR) CAD. used summary...
Background and purpose Cerebral microbleeds ( CMB s) are extravasations of blood from lipohyalinized or amyloid angiopathic cerebral arterioles, the presence numbers s significantly associated with development oral anticoagulation OA )‐related intracranial haemorrhage ICH ). The aim this study was to investigate whether there is a difference in burden according CHADS 2 scores CHA DS ‐ VAS c non‐valvular atrial fibrillation NVAF ) patients. Methods We included 550 ischaemic stroke patients...
The objective of this study was to assess the prognostic value interarm difference blood pressure (IAD) measured in acute ischemic stroke and investigate its association with systemic atherosclerosis.This a hospital-based retrospective observational study. Survival data systolic/diastolic IAD were collected patients stroke. Systemic atherosclerosis determined based on coronary CT angiography, transesophageal echocardiography, ankle-brachial index examination, cerebral angiography covering...
Background and purpose Increased arterial stiffness causes vessel damage in the end‐organs. Therefore small vessels brain may be susceptible to increased stiffness. Cerebral microbleeds ( CMB s) are topographically or pathophysiologically categorized as deep infratentorial type strictly lobar type. Whether presence location of s associated with brachial‐ankle pulse wave velocity (ba PWV ) which represents a measure was investigated. Methods Between June 2006 January 2012, 1137 consecutive...
Background and Purpose- We investigated whether measuring the volume density of a thrombus could predict nonrecanalization after intravenous thrombolysis. Methods- This study included retrospective cohort to develop computed tomography marker for predicting thrombolysis prospective multicenter validation this marker. The were measured semiautomatically using 3-dimensional software on baseline thin-section noncontrast (1 or 1.25 mm). Recanalization was assessed angiography magnetic resonance...