A5064733166- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Stroke Rehabilitation and Recovery
- COVID-19 and healthcare impacts
- Cardiovascular Health and Disease Prevention
- Long-Term Effects of COVID-19
- Intracerebral and Subarachnoid Hemorrhage Research
- Atrial Fibrillation Management and Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Oropharyngeal Anatomy and Pathologies
- Antiplatelet Therapy and Cardiovascular Diseases
- Aortic aneurysm repair treatments
- Blood Pressure and Hypertension Studies
- Machine Learning in Healthcare
- Peripheral Artery Disease Management
- Climate Change and Health Impacts
- Moyamoya disease diagnosis and treatment
- Cardiac Imaging and Diagnostics
- Epilepsy research and treatment
- Aortic Disease and Treatment Approaches
- Cardiac and Coronary Surgery Techniques
- Cerebral Venous Sinus Thrombosis
- Neurological Complications and Syndromes
National Health Insurance Service
2018-2025
National Health Insurance Service Ilsan Hospital
2018-2025
Gangnam Severance Hospital
2010-2025
Yonsei University
2008-2025
Kangwon National University
2001-2025
Boston Medical Center
2021-2022
Boston University
2021-2022
Hospital de Egas Moniz
2022
University of Thessaly
2022
Wonkwang University
2016-2021
Importance Optimal blood pressure (BP) control after successful reperfusion with endovascular thrombectomy (EVT) for patients acute ischemic stroke is unclear. Objective To determine whether intensive BP management during the first 24 hours leads to better clinical outcomes than conventional in who underwent EVT. Design, Setting, and Participants Multicenter, randomized, open-label trial a blinded end-point evaluation, conducted across 19 centers South Korea from June 2020 November 2022...
Carotid artery stenting (CAS) is an alternative treatment for patients with carotid stenosis who are not eligible endarterectomy. Dual antiplatelet therapy (DAPT) after CAS aims to prevent ischemic stroke. However, its optimal duration remains unclear. We aimed determine the of DAPT by identifying differences in clinical events that occur depending on maintenance period. Data were obtained from nationwide database Korean Health Insurance Review and Assessment Service between 2007 2019....
Fluid-attenuated inversion recovery hyperintense vessels (FHVs) are known to reflect stagnant or slow blood flow within the cerebral artery. FHVs frequently observed in patients with acute infarction accompanied by arterial occlusion significant stenosis of anterior circulation. However, have not been studied context posterior Thus, we investigated prevalence and its clinical significance artery (PCA) territory infarction.In this retrospective study, consecutive PCA who underwent MRI 1 week...
Background: anemia is known to be a risk factor for developing ischemic stroke in long-term follow-up studies, and it also increase the of death patients. We aimed determine association with after stroke. Methods: The study included patients from National Health Insurance Service cohort, January 2005 December 2015. Anemia were defined as those confirmed diagnostic codes related medications sample under age 18 excluded. To perform comparative analysis control group, twice many extracted by...
Patients with acute stroke are often accompanied by comorbidities, such as active cancer. However, adequate treatment guidelines not available for these patients. The purpose of this study was to evaluate the association between cancer and outcomes reperfusion therapy in patients stroke.We compared who underwent therapy, using a nationwide registry. We divided into 3 groups according activity: cancer, nonactive without history investigated processes, 24-hour neurological improvement, adverse...
Importance The associations between blood pressure (BP) decreases induced by medication and functional outcomes in patients with successful endovascular thrombectomy remain uncertain. Objective To evaluate whether BP reductions intravenous medications are associated poor at 3 months. Design, Setting, Participants This cohort study was a post hoc analysis of the Outcome Patients Treated With Intra-Arterial Thrombectomy–Optimal Blood Pressure Control trial, comparison intensive conventional...
The effects of blood pressure (BP) lowering in patients treated with intravenous tissue plasminogen activator (IV tPA) before endovascular thrombectomy (EVT) are unclear. This study aims to investigate whether intensive and conventional BP management affect outcomes differently, depending on IV tPA administration EVT. In this subgroup analysis the Outcome Patients Treated Intra-Arterial Thrombectomy-Optimal Blood Pressure Control (OPTIMAL-BP; ClinicalTrials.gov Identifier: NCT04205305)...
BACKGROUND The link between arterial stiffness, measured by estimated pulse wave velocity (ePWV), and outcomes following endovascular thrombectomy (EVT) has not been tested. This study aimed to determine whether ePWV predicts post‐EVT outcome in patients with acute ischemic stroke. METHODS was a secondary analysis of the OPTIMAL‐BP (Outcome Patients Treated With Intraarterial Thrombectomy–Optimal Blood Pressure Control) trial, which enrolled 302 EVT from 19 stroke centers South Korea June...
Background We investigated whether the association between blood pressure (BP) management in patients with successful reperfusion following endovascular therapy (EVT) and functional outcomes is mediated by BP variability parameters. Methods Results This a post hoc analysis of OPTIMAL‐BP (Outcome Patients Treated With Intra‐Arterial Thrombectomy‐Optimal Blood Pressure Control) trial, conducted at 19 centers South Korea. The primary outcome was 90‐day outcome, assessed using modified Rankin...
Background and Purpose: Previous studies have reported conflicting results about the prevalence of seizures in Alzheimer's disease (AD).There are few epidemiological on this topic Asia.Thus, objective study was to examine demographic clinical characteristics as well incidence for AD patients compared non-AD a prospective, longitudinal, community-based cohort with long follow-up.Methods: Data were collected from National Health Insurance Service-National Elderly Cohort (NHIS-elderly) Database...
We aimed to develop and validate machine learning models diagnose patients with ischemic stroke cancer through the analysis of histopathologic images thrombi obtained during endovascular thrombectomy.This was a retrospective study using prospective multicenter registry which enrolled consecutive acute from South Korea who underwent thrombectomy. This included admitted between July 1, 2017 December 31, 2021 6 academic university hospitals. Whole-slide scanning performed for...
This study was performed to evaluate the effects of nerve growth factor (NGF) upon angiogenesis in rat cornea, examine its possible application as an alternative angiogenic inducer and provide basic data for further studies. Angiogenesis induced by cornea micropocket assay, previously described. Eight thirty two eyes Sprague-Dawley rats were randomly assigned one four groups, namely, a non-NGF group (Group 0), 0.5 ng NGF 0.5), 1.0 1.0) 5.0 5.0). Pellets made poly-2-hydroxylethylmethacrylate...
Hyperintense vessels (HVs) on fluid-attenuated inversion recovery (FLAIR) imaging are associated with the leptomeningeal collateral circulation in cases of arterial occlusive lesions. Nevertheless, relationship between HVs FLAIR and time (ACT) cerebral angiography has not been defined.We analyzed images 11 patients acute occlusion distal internal carotid artery or proximal middle calculated difference ACT (DACT) infarcted normal hemispheres. was defined as interval from initial opacification...
Leptomeningeal collateral, in moyamoya disease (MMD), appears as an ivy sign on fluid-attenuated inversion-recovery (FLAIR) images. There has been little investigation into the relationship between presentation of signs and old brain lesions. We aimed to evaluate clinical significance whether they correlate with lesions severity symptoms patients MMD.FLAIR images 83 were reviewed. Each cerebral hemisphere was divided 4 regions each region scored based prominence sign. Total score (TIS)...
Background and Purpose We aimed to develop a model predicting early recanalization after intravenous tissue plasminogen activator (t-PA) treatment in large-vessel occlusion.Methods Using data from two different multicenter prospective cohorts, we determined the factors associated with immediately t-PA stroke patients occlusion, developed validated prediction for recanalization. Clot volume was semiautomatically measured on thin-section computed tomography using software, degree of...
A high and low estimated glomerular filtration rate (eGFR) could affect outcomes after reperfusion therapy for ischemic stroke. This study aimed to determine whether renal function based on eGFR affects mortality risk in patients with stroke within 6 months following therapy.This prospective registry-based cohort included 2266 who received between January 2000 September 2019 were registered the SECRET (Selection Criteria Endovascular Thrombectomy Thrombolytic Therapy) or Yonsei Stroke...
<h3>BACKGROUND AND PURPOSE:</h3> Fluid-attenuated inversion recovery hyperintense vessels in stroke represent leptomeningeal collateral flow. We presumed that FLAIR would be more closely associated with arterial stenosis and perfusion abnormality ischemic on T2-PROPELLER-FLAIR than T2-FLAIR. <h3>MATERIALS METHODS:</h3> retrospectively reviewed 35 patients middle cerebral territorial infarction who underwent MR imaging. vessel scores were graded according to the number of segments MCA ASPECTS...
Carotid artery stenting is widely performed for extracranial carotid stenosis.In-stent thrombosis a rare but potentially devastating complication.We present case of acute in-stent immediately following stent insertion and post-balloon dilatation in 64-year-old male.Thrombosis was successfully treated by intravenous tirofiban, glycoprotein IIb/IIIa receptor inhibitor.
<h3>BACKGROUND AND PURPOSE:</h3> There is an uncertainty about the association between intracranial aneurysms and aortic dissection. We aimed to determine prevalence of in patients with dissection evaluate independent risk factors for presence these patients. <h3>MATERIALS METHODS:</h3> Seventy-one a confirmed who underwent additional brain imaging were enrolled as group, 2118 healthy individuals imaging, controls. Demographic data obtained from their medical records, including age, sex,...
Clopidogrel is metabolized by the hepatic cytochrome P450 (CYP) system into its active thiol metabolite. CYP3A4 involved in metabolism of both clopidogrel and dihydropyridine calcium channel blockers (CCBs). A few reports have suggested an inhibitory interaction between CCBs clopidogrel. Accordingly, aim this study was to determine effect on antiplatelet activity serial P2Y12 reaction unit (PRU) measurements. We assessed changes patients receiving for at least 2 months prior enrollment...