A5058759251- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Stroke Rehabilitation and Recovery
- Cardiac Imaging and Diagnostics
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Nuclear and radioactivity studies
- Cardiovascular Health and Disease Prevention
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiovascular and Diving-Related Complications
- Graphite, nuclear technology, radiation studies
- Atrial Fibrillation Management and Outcomes
- Neurological Complications and Syndromes
- Advanced Radiotherapy Techniques
- Breast Cancer Treatment Studies
- Alcoholism and Thiamine Deficiency
- Nuclear reactor physics and engineering
- Moyamoya disease diagnosis and treatment
- Advanced Image and Video Retrieval Techniques
- Photoacoustic and Ultrasonic Imaging
Gachon University Gil Medical Center
2015-2024
Gachon University
2014-2023
Deleted Institution
2013-2021
Soonchunhyang University
2021
Korea Institute of Nuclear Safety
2009-2018
Ajou University
2005-2016
Kangwon National University Hospital
2014
Seoul National University
2003
Importance Optimal blood pressure (BP) control after successful reperfusion with endovascular thrombectomy (EVT) for patients acute ischemic stroke is unclear. Objective To determine whether intensive BP management during the first 24 hours leads to better clinical outcomes than conventional in who underwent EVT. Design, Setting, and Participants Multicenter, randomized, open-label trial a blinded end-point evaluation, conducted across 19 centers South Korea from June 2020 November 2022...
<b>BACKGROUND AND PURPOSE:</b> The traditional paradigm has regarded essential tremor (ET) as a benign disorder. However, recent clinical, neuroimaging, and neuropathologic studies suggest that ET may be progressive neurologic Based on clinicopathologic findings cerebellum its outflow are the key structures in degeneration of gray matter is followed by consequent wallerian white (WM) fibers, aim present study was to investigate changes anisotropy patients with ET. <b>MATERIALS METHODS:</b>...
<h3>Background</h3> To investigate the influence of galantamine on linguistic function, any associated factors in patients with chronic post-stroke aphasia were analysed. <h3>Methods</h3> 45 younger than 75 years (≥1 year since onset) prospectively enrolled study. Language testing was performed at weeks 0 and 16. Initial dose 8 mg/day for 4 weeks, 16 following 12 weeks. Efficacy evaluated by sum four domains (spontaneous speech, comprehension, repetition naming) quotient (AQ) Western Aphasia...
Patients with acute stroke are often accompanied by comorbidities, such as active cancer. However, adequate treatment guidelines not available for these patients. The purpose of this study was to evaluate the association between cancer and outcomes reperfusion therapy in patients stroke.We compared who underwent therapy, using a nationwide registry. We divided into 3 groups according activity: cancer, nonactive without history investigated processes, 24-hour neurological improvement, adverse...
Nelonemdaz is a multitarget neuroprotectant that selectively blocks N-methyl-D-aspartate receptors and scavenges free radicals, as proven in preclinical ischemia-reperfusion studies. We aimed to evaluate the safety efficacy of nelonemdaz patients with acute ischemic stroke receiving endovascular reperfusion therapy.
Background: Information on the mechanism of recurrent stroke may help physicians treating patients with ischemic stroke.However, mechanisms recurrence in each subtype are not well known, especially Asians.Objective: To compare index and stroke.Design: Analysis data from a prospective acute registry.Setting: University hospital.Patients: Using clinical syndrome, diffusionweighted imaging, vascular studies, we divided 901 into 5 groups: large-artery atherosclerosis, cardioembolism,...
<b><i>Background/Aims:</i></b> To better understand potential risks for vertebral artery (VA) dissection (VAD), we compared intracranial and extracranial VADs. <b><i>Methods:</i></b> We analyzed consecutively admitted VAD patients over a 9-year period in whom was confirmed by angiography. All were categorized as having or VAD, demographic radiological characteristics of compared. used multivariate analysis to predict the...
Abstract In this study, the prevalence of abnormality in putative nigrosome 1 and 4 (N1 N4, respectively) was investigated early versus late‐stage idiopathic Parkinson's disease (IPD) patients. A total 128 IPD patients (early stage[ n = 89]; late 39]) 15 healthy subjects were scanned for high‐resolution (0.5 × 0.5 1.0 mm 3 ) multiecho gradient‐recalled echo MRI dopamine transporter PET imaging. The data processed susceptibility map‐weighted imaging (SMWI) to improve a contrast‐to‐noise...
Cardiac sympathetic dysfunction was investigated using 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy in 20 patients with drug induced parkinsonism (DIP). The mean heart to mediastinum ratio significantly greater DIP than those Parkinson's disease (mean (SD): 2.07 (0.39) v 1.28 (0.15), p<0.001). MIBG uptake not different between the and controls. Two whose reduced showed persistent responded dramatically levodopa.
Reports of serious neuropsychiatric events (NPEs), specifically suicide/suicide attempts, following the use oseltamivir have led to public concerns. Our aim in this study was determine whether an association exists between and NPEs.This a population-based, retrospective, cohort on random sample 50% individuals Korean National Health Insurance Service (KNIS) database aged ≥8 years who were diagnosed with influenza 2009 2017. The primary exposure prescription at time diagnosis, whereas outcome...
Resuming anticoagulation after an intracranial hemorrhage (ICH) poses a clinical conundrum. The absence of relevant guidelines has led to wide variations in the decision on resuming therapies ICH. This study aimed evaluate risks therapy severe thrombotic events (STE) and (SHE) Korea compare effects novel direct oral anticoagulants (NOACs) warfarin patients with AF.This was performed using Korean national health insurance claims data obtained between 2002 2017 from individuals who had...
Automated measurement of the Alberta Stroke Program Early Computed Tomography Score (ASPECTS) can support clinical decision making. Based on a deep learning algorithm, we developed an automated ASPECTS scoring system (Heuron ASPECTS) and validated its performance in prespecified trial.
Neuromodulation using high-energy focused ultrasound (FUS) has recently been developed for various neurological disorders, including tremors, epilepsy, and neuropathic pain. We investigated the safety efficacy of low-energy FUS patients with chronic conducted a prospective single-arm trial 3-month follow-up new transcranial, navigation-guided, (tcNgFUS) technology to stimulate anterior cingulate cortex. Eleven underwent frequency 250 kHz spatial-peak temporal-average intensity 0.72 W/cm2. A...
(123)I cardiac meta-iodobenzylguanidine (MIBG), an analogue of norepinephrine, has been used to estimate myocardial sympathetic nerve function. We investigate whether cardiac-MIBG SPECT is clinically applicable in the differentiation Parkinson's disease (PD) from parkinsonian syndromes.Cardiac-MIBG scintigraphy was performed 27 controls, 40 patients with PD and 52 other syndromes comprising 23 multiple system atrophy (MSA), 26 drug-induced parkinsonism (DIP), 3 corticobasal degeneration...
Background and purpose: Extensive evidence has shown that oxidative stress mediates neuronal death in animal models of hypoxic–ischaemia. Brain biomarkers need to be identified order better understand treat brain damage human stroke patients. The present study was conducted identify potential target proteins the cerebrospinal fluid (CSF) patients with acute ischaemic injury. Methods: We performed two-dimensional polyacrylamide gel electrophoresis separate protein samples obtained from CSF...
Cognitive impairment is a common nonmotor symptom of Parkinson's disease (PD) and associated with high mortality, caregiver distress, nursing home placement. The risk factors for cognitive decline in PD patients include advanced age, longer duration, rapid eye movement sleep behavior disorder, hallucinations, excessive daytime sleepiness, nontremor symptoms including bradykinesia, rigidity, postural instability, gait disturbance. We conducted cross-sectional study to determine which types...
Background and Purpose We aimed to develop a model predicting early recanalization after intravenous tissue plasminogen activator (t-PA) treatment in large-vessel occlusion.Methods Using data from two different multicenter prospective cohorts, we determined the factors associated with immediately t-PA stroke patients occlusion, developed validated prediction for recanalization. Clot volume was semiautomatically measured on thin-section computed tomography using software, degree of...
Background The prevalence of patent foramen ovale (PFO) is higher among adult migraine patients. purpose this study was to determine the frequency PFO in children and adolescent Methods results A total 32 patients with (divided into two subgroups, aura subgroup without subgroup) 31 normal control subjects were enrolled study. All participants underwent transthoracic echocardiography an agitated saline test. We compared severity right-to-left shunt (RLS) each group. No statistical difference...