A5028160527- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Extracellular vesicles in disease
- Alzheimer's disease research and treatments
- Cerebrovascular and Carotid Artery Diseases
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Acute Ischemic Stroke Management
- Cerebrovascular and genetic disorders
- Moyamoya disease diagnosis and treatment
- Stroke Rehabilitation and Recovery
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Spinal Cord Injury Research
- S100 Proteins and Annexins
- Aortic Disease and Treatment Approaches
- Plasma Diagnostics and Applications
- Angiogenesis and VEGF in Cancer
- Mitochondrial Function and Pathology
- Vasculitis and related conditions
- CRISPR and Genetic Engineering
- Lipoproteins and Cardiovascular Health
- Parkinson's Disease Mechanisms and Treatments
- Spondyloarthritis Studies and Treatments
Asan Medical Center
2021-2024
University of Ulsan
2021-2024
Ulsan College
2021-2024
Sungkyunkwan University
2010-2021
Samsung Medical Center
2010-2021
Regenerative Medicine Institute
2021
Ajou University Hospital
2021
Keimyung University Dongsan Medical Center
2021
Keimyung University
2021
Gyeongsang National University
2021
Abstract We previously evaluated the short-term follow-up preliminary data of mesenchymal stem cells (MSCs) transplantation in patients with ischemic stroke. The present study was conducted to evaluate long-term safety and efficacy i.v. MSCs a larger population. To accomplish this, we performed an open-label, observer-blinded clinical trial 85 severe middle cerebral artery territory infarct. Patients were randomly allocated one two groups, those who received autologous ex vivo cultured (MSC...
<h3>Objective</h3> To test whether autologous modified mesenchymal stem cells (MSCs) improve recovery in patients with chronic major stroke. <h3>Methods</h3> In this prospective, open-label, randomized controlled trial blinded outcome evaluation, severe middle cerebral artery territory infarct within 90 days of symptom onset were assigned, a 2:1 ratio, to receive preconditioned MSC injections (MSC group) or standard treatment alone (control group). The primary was the score on Rankin Scale...
The endoplasmic reticulum (ER) stress results from disrupted protein folding triggered by mutation or oxidation, reduced proteasome activity, and altered Ca2+ homeostasis. ER is accompanied activation of the unfolded response (UPR) cell death pathway. We examined if UPR pathway would be activated in Alzheimer's disease (AD). RT-PCR experiments revealed increased splicing X-box binding protein-1 (XBP-1), an transcription factor, AD compared with age-matched control. Among target genes XBP-1,...
Microvesicles (MVs) released by cells are involved in a multitude of physiological events as important mediators intercellular communication. MVs derived from mesenchymal stem (MSCs) contain various paracrine factors the that primarily contribute to their therapeutic efficacy observed numerous clinical trials. As nano-sized and bi-lipid layered vesicles retaining potency equivalent MSCs, MSC-derived have been focus ideal medicinal candidates for regenerative medicine, preferred over MSC...
Background and PurposezzOxidative stress is involved in the pathophysiological mechanisms of stroke (e.g., atherosclerosis) brain injury after ischemic stroke.Statins, which inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, have both pleiotropic low-density lipoprotein (LDL)-lowering properties.Recent trials shown that highdose statins reduce risk cerebrovascular events.However, there a paucity data regarding changes oxidative markers patients with atherosclerotic statin...
Recovery after a major stroke is usually limited, but cell therapy for patients with fixed neurologic deficits emerging. Several recent clinical trials have investigated mesenchymal stem (MSC) ischemic stroke. We previously reported the results of controlled trial on application autologous MSCs in long-term follow-up up to 5 years (the 'STem Application Researches and Trials In NeuroloGy' (STARTING) study). The from this pilot are challenging, also raise important issues. addition, there...
Background Cancer and stroke, which are known to be associated with one another, the most common causes of death in elderly. However, pathomechanisms that lead stroke cancer patients not well known. Circulating extracellular vesicles (EVs) play a role cancer-associated thrombosis tumor progression. Therefore, we hypothesized cell-derived EVs cause cancer-related coagulopathy resulting ischemic stroke. Methods Serum levels D-dimer expressing markers for cells (epithelial cell adhesion...
Moyamoya disease is a unique cerebrovascular occlusive of unknown etiology. Ring finger protein 213 (RNF213) was identified as susceptibility gene for in East Asian countries. However, the pathogenesis remains unclear.We prospectively analyzed clinical data 139 patients with (108 bilateral disease, 31 unilateral disease), 61 intracranial atherosclerotic stroke, and 68 healthy subjects. We compared genetic (RNF213 variant) biomarkers caveolae (caveolin-1), angiogenesis (vascular endothelial...
Background and Purpose— Moyamoya disease (MMD) is a unique cerebrovascular occlusive characterized by progressive stenosis negative remodeling of the distal internal carotid artery (ICA). We hypothesized that cav-1 (caveolin-1)—a protein controls regulation endothelial vesicular trafficking signal transduction—is associated with in MMD. Methods— prospectively recruited 77 consecutive patients MMD diagnosed via conventional angiography. Seventeen intracranial atherosclerotic stroke no RNF213...
Preclinical and clinical studies have shown that the application of CD105+ mesenchymal stem cells (MSCs) is feasible may lead to recovery after stroke. In addition, circulating microparticles are reportedly functional in various disease conditions. We tested levels patients with acute ischemic The expression CD105 (a surface marker MSCs) CXCR4 CXC chemokine receptor for MSC homing) on was evaluated by flow cytometry samples from 111 50 healthy subjects. percentage apoptotic determined based...
The goal of the present study was to examine neuroprotective and functional significance targeting both N-methyl-d-aspartate (NMDA) receptor–mediated excitotoxicity oxidative stress using a dual-acting compound, Neu2000, in rat model moderate spinal cord injury (SCI). An initial set experiments conducted uninjured rats pharmacokinetic profile Neu2000 following intraperitoneal intravenous administration. A second experiment measured free radical production mitochondria isolated from sham or...
Stroke induces complex and dynamic, local systemic changes including inflammatory reactions, immune responses, repair recovery processes. Mesenchymal stem cells (MSCs) have been shown to enhance neurological after stroke. We hypothesized that serum factors play a critical role in the activation of bone marrow (BM) MSCs stroke such as by increasing proliferation, paracrine effects, rejuvenation. Human (hMSCs) were grown fetal bovine (FBS), normal healthy control (NS), or patient (SS)....
An abnormal reorganization of the dentate gyrus and neurotoxic events are important phenotypes in hippocampus patients with temporal lobe epilepsy (TLE). The effects morin, a bioflavonoid constituent many herbs fruits, on epileptic seizures have not yet been elucidated, though its beneficial effects, such as anti-inflammatory neuroprotective properties, well-described various neurodegenerative diseases. In present study, we investigated whether treatment morin hydrate (MH) can reduce...
Abnormal reorganization of the dentate gyrus and neuroinflammation in hippocampus represent characteristic phenotypes patients suffering from temporal lobe epilepsy. Hesperetin, a flavanone abundant citrus fruit, is known to have protective effects by preventing inflammation oxidative stress neuronal cultures adult murine brain. However, hesperetin against epileptic seizures vivo remain unclear, despite one study reporting anticonvulsant vitro. In this study, we report that oral...
Background and purpose: Extensive evidence has shown that oxidative stress mediates neuronal death in animal models of hypoxic–ischaemia. Brain biomarkers need to be identified order better understand treat brain damage human stroke patients. The present study was conducted identify potential target proteins the cerebrospinal fluid (CSF) patients with acute ischaemic injury. Methods: We performed two-dimensional polyacrylamide gel electrophoresis separate protein samples obtained from CSF...