A5100755886- Nutrition and Health in Aging
- Cardiovascular Disease and Adiposity
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Body Composition Measurement Techniques
- Cardiac Imaging and Diagnostics
- Chronic Kidney Disease and Diabetes
- Diet and metabolism studies
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Lipoproteins and Cardiovascular Health
- Cardiovascular Health and Disease Prevention
- Adipokines, Inflammation, and Metabolic Diseases
- Blood Pressure and Hypertension Studies
- Gastric Cancer Management and Outcomes
- Dialysis and Renal Disease Management
- Lymphoma Diagnosis and Treatment
- Cancer Risks and Factors
- Diabetes and associated disorders
- Bariatric Surgery and Outcomes
- Colorectal Cancer Screening and Detection
- Thyroid Cancer Diagnosis and Treatment
- HIV-related health complications and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiovascular Health and Risk Factors
Asan Medical Center
2014-2024
Ulsan College
2014-2024
University of Ulsan
2014-2024
Boramae Medical Center
2023
Chung-Ang University Hospital
2023
Catholic University of Daegu
2023
Samsung Medical Center
2018
Jeju National University
2015-2016
Catholic University of Korea
2013-2014
CHA University
2014
Abstract Despite extensive experimental and animal evidence about the detrimental effects of iron its overload on bone metabolism, there have been no clinical studies relating stores to loss, especially in nonpathologic conditions. In present study, we performed a large longitudinal study evaluate serum ferritin concentrations relation annualized changes mineral density (BMD) healthy Koreans. A total 1729 subjects (940 postmenopausal women 789 middle-aged men) aged 40 years or older who had...
Background/Aims: To investigate whether non-alcoholic fatty liver disease (NAFLD) in individuals without generalized obesity is associated with visceral fat (VFO), sarcopenia, and/or myosteatosis.Methods: This cross-sectional analysis included 14,400 (7,470 men) who underwent abdominal computed tomography scans during routine health examinations. The total muscle area (TAMA) and skeletal (SMA) at the 3<sup>rd</sup> lumbar vertebral level were measured. SMA was divided into normal...
OBJECTIVE The relationship between impaired fasting glucose (IFG) and risk of cardiovascular disease (CVD) or ischemic heart (IHD) varies widely according to sex ethnicity. We evaluated the IFG CVD IHD among Korean men women. RESEARCH DESIGN AND METHODS A total 408,022 individuals who underwent voluntary private health examinations in 17 centers South Korea were followed for 10 years. Data regarding events obtained from National Health Insurance database. was categorized as grade 1 (fasting...
This study sought to investigate whether the metabolically healthy obese (MHO) phenotype is associated with an increased risk of incident type 2 diabetes in a Korean population and, if so, systemic inflammation affects this MHO individuals.The comprised 36 135 Koreans without diabetes. Participants were stratified by body mass index (cutoff value, 25.0 kg/m(2)) and metabolic health state (assessed using Adult Treatment Panel-III criteria). High-sensitive C-reactive protein (hsCRP) was used...
The triglyceride glucose (TyG) index, a product of and fasting glucose, is reliable marker for insulin resistance. We aimed to investigate the association between TyG-related markers coronary artery calcification (CAC) progression. enrolled 1145 asymptomatic participants who underwent repeated CAC score measurements during routine health examinations. Homeostasis model assessment resistance (HOMA-IR), TyG TyG-BMI (body mass index), TyG-WC (waist circumference) were calculated. Progression...
This study aimed to determine the optimal cut-off values of visceral fat area (VFA) and visceral-to-subcutaneous ratio (VSR) for predicting incident type 2 diabetes mellitus (T2DM).A total 10,882 individuals (6,835 men; 4,047 women) free T2DM at baseline aged between 30 79 years who underwent abdominal computed tomography scan 2012 2013 as a part routine health check-ups were included followed. VFA, subcutaneous area, VSR on L3 vertebral level measured baseline.During median follow-up 4.8...
Some individuals with metabolically healthy obesity (MHO) convert to unhealthy (MUO) phenotype, and visceral adiposity is one of proposed mechanisms underlying such conversion. Visceral adipose index (VAI) a novel mathematical model which estimates based on anthropometric lipid profiles. We aimed determine the association VAI-estimated MHO-to-MUO conversion predictive value VAI in estimating unfavorable outcomes.A total 2,204 Korean subjects MHO phenotype were enrolled stratified by body...
Abstract Background Although computed tomography (CT) is considered the gold standard for investigating skeletal muscles, diagnostic cutoff points sarcopenia have not been established. We therefore suggested clinically relevant based on reference values of muscle area (SMA) measured by CT scan in a large-sized healthy Asian population. Methods This cross-sectional analysis included 11,845 subjects (7,314 men, 4,531 women) who underwent abdominal scans South Korea. SMA including all muscles...
Abstract Objective This study evaluated whether sarcopenic obesity is closely associated with muscle quality using abdominal computed tomography. Methods cross‐sectional included 13,612 participants who underwent The area of the skeletal was measured at L3 level (total [TAMA]) and segmented into normal attenuation (NAMA, +30 to +150 Hounsfield units), low (−29 +29 intramuscular adipose tissue (−190 −30 units). NAMA/TAMA index calculated by dividing NAMA TAMA multiplying 100, lowest quartile...
Visceral adipose tissue-derived serine protease inhibitor (vaspin) is a novel adipokine with insulin-sensitizing effects. However, the physiological role for vaspin in human metabolic regulation remains to be established.We studied 24-h profiles of circulating concentrations relation meal ingestion normal adults.Blood samples were drawn 39 times throughout period from 10 healthy male subjects provided meals on fixed schedule. On separate day, four fasted and then an unexpected clarify effect...
Objective The degree of subclinical coronary atherosclerosis detected by multidetector computed tomography (MDCT) in four groups defined the state metabolic health and obesity an asymptomatic Korean population was compared. Methods data 4009 subjects who participated a routine screening examination were collected. Significant artery stenosis as >50% stenosis, plaque, calcium scores (CACS) assessed MDCT. Participants stratified BMI (cut-off value, 25 kg/m2) metabolically healthy state, which...
Because of the poor prognosis diffuse-type gastric cancer, early detection is important. We investigated clinical characteristics and cancer (EGC) diagnosed in subjects during health check-ups.Among 121,111 who underwent gastroscopy a routine check-up, we identified 282 patients with 286 EGC lesions reviewed their tumor-specific parameters.Patients were younger, 48.1% them female. Serum anti-Helicobacter pylori IgG (Hp-IgG) was positive 90.7% (vs 75.9% intestinal-type EGC, p=0.002),...
Background and Purpose— Moyamoya disease (MMD) is a unique cerebrovascular occlusive characterized by progressive stenosis negative remodeling of the distal internal carotid artery (ICA). We hypothesized that cav-1 (caveolin-1)—a protein controls regulation endothelial vesicular trafficking signal transduction—is associated with in MMD. Methods— prospectively recruited 77 consecutive patients MMD diagnosed via conventional angiography. Seventeen intracranial atherosclerotic stroke no RNF213...
Abstract Objective The aim of this study was to examine whether higher skeletal muscle mass is associated with a metabolically healthy phenotype and quality affects metabolic health. Methods This cross‐sectional analysis included 20,659 participants (7,966 women) who underwent abdominal computed tomography scans during health checkups. total area (TAMA) on the third lumbar vertebral level demarcated. Intermuscular adipose tissue were measured. divided into normal attenuation (NAMA) low...
Infantile hepatic hemangioendothelioma (IHHE) is the most common type of vascular tumor in infancy. We conducted this study to review our clinical experience patients with IHHE and suggest management strategies.We retrospectively analyzed medical records 23 (10 males, 13 females) treated at Asan Medical Center between 1996 2009.Median age diagnosis was 38 days (range, 1 381 days). Seven (30%) were diagnosed based on sonographically detected fetal liver masses, 5 (22%) incidentally absence...
Mitochondrial dysfunction and endoplasmic reticulum (ER) stress are considered the key determinants of insulin resistance. Impaired mitochondrial function in obese animals was shown to induce ER response, resulting reduced adiponectin synthesis adipocytes. The expression inducible nitric oxide synthase (iNOS) is increased adipose tissues genetic dietary models obesity. In this study, we examined whether activation iNOS responsible for palmitate-induced dysfunction, stress, decreased 3T3L1 As...
Objective: Low muscle mass was known to be associated with cardiovascular diseases. However, only few studies investigated the association between quality and subclinical coronary atherosclerosis. Thus, we evaluated whether measured by abdominal computed tomography is risk of artery calcification. Approach Results: We conducted a cross-sectional study on 4068 subjects without disease who underwent 2012 2013 during health examinations. The area skeletal at L3 level (total area) segmented into...
Advanced liver fibrosis and coronary artery calcification (CAC) progression has been reported to correlate with cardiovascular disease. This study investigated the association between noninvasive score CAC in patients nonalcoholic fatty disease (NAFLD). We included 1173 asymptomatic adults scores from 2007-2013. was defined as newly incident or a ≥ 2.5-unit increase final square root. Liver assessed using fibrosis-4 index (FIB-4) NAFLD (NFS). A total of 293 (25.0%) subjects developed CAC....
The triglyceride glucose (TyG) index has been suggested as a marker for insulin resistance; however, few studies have investigated the clinical implications of markers that combine obesity with TyG index. This study aimed to investigate associations between non-alcoholic fatty liver disease (NAFLD) and TyG-related in healthy subjects Korea. We enrolled 21,001 asymptomatic participants who underwent hepatic ultrasonography. homeostasis model assessment resistance (HOMA-IR), index, TyG-body...
Background: The association of myosteatosis measured using visual muscular quality map in computed tomography (CT) with nonalcoholic fatty liver disease (NAFLD), its severity, and fibrosis was analyzed a large population.Methods: Subjects (<i>n</i>=13,452) abdominal CT between 2012 2013 were total muscle area (TAMA) at L3 level. TAMA segmented into intramuscular adipose tissue skeletal (SMA), which further classified normal attenuation (NAMA) low (LAMA). following variables...