A5069341668- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Sleep and Wakefulness Research
- Sleep and related disorders
- Functional Brain Connectivity Studies
- Obstructive Sleep Apnea Research
- Cholinesterase and Neurodegenerative Diseases
- Cerebrovascular and Carotid Artery Diseases
- Neurobiology of Language and Bilingualism
- Neuroscience of respiration and sleep
- Neurological Disorders and Treatments
- Advanced Neuroimaging Techniques and Applications
- Acute Ischemic Stroke Management
- Restless Legs Syndrome Research
- Amyotrophic Lateral Sclerosis Research
- Diverse Approaches in Healthcare and Education Studies
- Frailty in Older Adults
- Brain Tumor Detection and Classification
- Ginkgo biloba and Cashew Applications
- S100 Proteins and Annexins
- Nutritional Studies and Diet
- Health Systems, Economic Evaluations, Quality of Life
- Nutrition and Health in Aging
Gachon University Gil Medical Center
2016-2025
Deleted Institution
2011-2024
Gachon University
2013-2023
Ewha Womans University Medical Center
2023
Inha University
2023
Seoul National University Bundang Hospital
2023
Catholic University of Korea
2023
Neurology, Inc
2017
Charles R. Drew University of Medicine and Science
2015
Hanyang University
2004-2014
Because the signs associated with dementia due to Alzheimer disease (AD) can be heterogeneous, goal of this study was use 3-dimensional MRI examine various patterns cortical atrophy that AD type, and investigate whether categorized into anatomical subtypes.
Abstract Background Neuropsychological tests (NPTs) are important tools for informing diagnoses of cognitive impairment (CI). However, interpreting NPTs requires specialists and is thus time-consuming. To streamline the application in clinical settings, we developed evaluated accuracy a machine learning algorithm using multi-center NPT data. Methods Multi-center data were obtained from 14,926 formal neuropsychological assessments (Seoul Screening Battery), which classified into normal...
Center for Dementia of South Korea) StudyWith rapid population aging, the socioeconomic burden caused by dementia care is snowballing.Although a few community-based studies Alzheimer's disease (AD) have been performed in Korea, there has never nationwide hospital-based study thereof.We aimed to identify demographics and clinical characteristics mild-to-moderate AD patients from Clinical Research Korea (CREDOS) registry.A total 1,786 were consecutively included September 2005 June 2010.Each...
Background and PurposezzIt has been shown that sleep problems in Alzheimer's disease (AD) are associated with cognitive impairment behavioral problems.In fact, most of studies have founded daytime sleepiness is significantly correlated decline AD.However, a few also nighttime function symptoms AD.Accordingly, the aim this study was to evaluate effects on cognition psychological dementia (BPSD) AD.MethodszzThe population comprised 117 subjects: 63 AD patients 54 age-and sexmatched...
This study explored whether religiosity/spirituality has a protective role against negative caregiving outcomes, in large multicenter nationwide sample of caregivers patients with dementia South Korea. Additionally, this was the first to examine could affect outcomes according various religious affiliations caregivers.The conducted on 476 participated Clinical Research Center for Dementia Korea (CREDOS). We examined moderating effect each three dimensions (organizational activity, ORA;...
Alzheimer's disease (AD) patients are known to have heterogeneous clinical presentation and pathologic patterns. We hypothesize that AD dementia can be categorized into subtypes based on multimodal imaging biomarkers such as magnetic resonance (MRI), tau positron emission tomography (PET), amyloid PET. collected 3T MRI, 18F-THK5351 PET, 18F-flutemetamol (FLUTE) PET data from 83 with (Clinical Dementia Rating ≤ 1) 60 normal controls (NC), applied surface-based analyses measure cortical...
Dementia subtypes, including Alzheimer's dementia (AD), with Lewy bodies (DLB), and frontotemporal (FTD), pose diagnostic challenges. This review examines the effectiveness of
BACKGROUND: Many dementia and Alzheimers disease (AD) registries operate at local or national levels without standardization comprehensive real-world data (RWD) collection. This initiative sought to achieve consensus among experts on priority outcomes measures for clinical practice in caring patients with symptomatic AD, particularly the mild cognitive impairment moderate stages. OBJECTIVE: The primary aim was define a minimum dataset (MDS) extended (EDS) collect RWD new International...
Dementia often accompanies behavioral and psychological symptoms of dementia (BPSD), including agitation, aggression, depression, psychosis, which impact patients' quality life caregiver burden. Effective management BPSD is essential to support patient well-being. This study presents evidence-based clinical practice guidelines for pharmacological treatments in dementia, focusing on antipsychotics, antidepressants, cognitive enhancers, other medications. guideline was developed by the Korean...
This clinical practice guideline provides evidence-based recommendations for treatment of dementia, focusing on cholinesterase inhibitors and N-methyl-D-aspartate (NMDA) receptor antagonists Alzheimer's disease (AD) other types dementia. Using the Population, Intervention, Comparison, Outcomes (PICO) framework, we developed key questions conducted systematic literature reviews. A multidisciplinary panel experts, organized by Korean Dementia Association, evaluated randomized controlled trials...
Introduction: Subjective cognitive decline (SCD) is considered a preclinical manifestation of Alzheimer’s disease (AD). Recent research suggests that subtle changes in SCD are linked to an increased risk clinical decline. This study investigates the longitudinal trajectories both objective and self-reported functions individuals with SCD, focus on impact impairment (SCI). Methods: A total 107 at least two annual follow-ups, were included this study. We analyzed subjective functions, assessed...
Many dementia and Alzheimer's disease (AD) registries operate at local or national levels without standardization comprehensive real-world data (RWD) collection. This initiative sought to achieve consensus among experts on priority outcomes measures for clinical practice in caring patients with symptomatic AD, particularly the mild cognitive impairment moderate stages. The primary aim was define a minimum dataset (MDS) extended (EDS) collect RWD new International Registry AD Other Dementias...
ABSTRACT Background: Personality may predispose family caregivers to experience caregiving differently in similar situations and influence the outcomes of caregiving. A limited body research has examined role some personality traits for health-related quality life (HRQoL) among persons with dementia (PWD) relation burden depression. Methods: Data from a large clinic-based national study South Korea, Caregivers Alzheimer's Disease Research (CARE), were analyzed ( N = 476). Path analysis was...
We investigated the associations of periventricular white matter hyperintensities (PWMHs) and deep (DWMHs) with cognition, activities daily living (ADLs), neuropsychiatric symptoms in dementia. This was a hospital-based MRI300 study. recruited patients newly diagnosed mild-to-moderate dementia caused either by Alzheimer’s disease or subcortical ischemic vascular from 13 clinics at university general hospitals South Korea. enrolled 289 aged over 50 August 2007 to March 2008. compared ADLs,...
Background & Objective: Early-onset Alzheimer's disease (EOAD, onset age < 65 years) may differ from late-onset (LOAD) in terms of cognitive profiles and neuropsychiatric symptoms. There have been few studies for Korean EOA
Background: Although plasma amyloid-β (Aβ) levels have been evaluated as a possible diagnostic marker of Alzheimer's disease (AD), the findings are inconsistent. Objective: The present study aimed to validate Aβ40, Aβ42, and Aβ40/Aβ42 ratio biomarkers AD in subjects with early-onset (EOAD) without familial genetic mutations. Methods: Patients sporadic EOAD (sEOAD) were prospectively recruited by nine neurology clinics. Plasma Aβ40 Aβ42 measured using sandwich enzyme-linked immunosorbent...
Patients with simple snoring (SS) often complain of poor sleep quality despite a normal apnoea-hypopnoea index (AHI). We aimed to identify the difference in power spectral density electroencephalography (EEG) between patients SS and those obstructive apnoea (OSA). compared absolute values standard EEG frequency bands (n = 42) OSA 129) groups during non-rapid eye movement (NREM) period, after controlling for age sex. also analysed partial correlation AHI bands. The beta delta were higher...
The Clinical Research Center for Dementia of South Korea (CREDOS), a nation-wide clinical dementia research group, has prepared practice guidelines (CPG) tailored to the Korean population. In this article, summary CREDOS CPG is presented with and English version full report included in appendix. intended not only psychiatrists neurologists, but also internists, family physicians, other primary care physicians involved prevention early diagnosis dementia. While our mainly covers Alzheimer's...
Background: Semantic variant primary progressive aphasia (svPPA) has been associated with a variety of proteinopathies, mainly transactive response DNA-binding protein, but also tau and β-amyloid. Recently selective tracers for positron emission tomography (PET) have developed to determine the presence cerebral deposits in vivo. Here, we investigated topographical distribution THK5351 svPPA patients. Materials Methods: Five patients, 14 Alzheimer’s disease 15 age-matched normal controls...